A5066650733- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Estrogen and related hormone effects
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Risks and Factors
- Bone health and treatments
- Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Colorectal Cancer Treatments and Studies
- BRCA gene mutations in cancer
- Breast Lesions and Carcinomas
- Genetic factors in colorectal cancer
- Nutritional Studies and Diet
- Economic and Financial Impacts of Cancer
- Cancer survivorship and care
- Lymphoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Central Venous Catheters and Hemodialysis
- Cancer Cells and Metastasis
Hospital Universitario de Toledo
2022-2025
Complejo Hospitalario Universitario de Toledo
2009-2025
Centro de Cirugía de Mínima Invasión Jesús Usón
2025
GEICAM – Spanish Breast Cancer Group
2013-2024
Hospital Virgen de la Salud
2015-2024
Universidad Regional Autónoma de Los Andes
2024
Corvid Technologies (United States)
2020
Hospital San Pedro de Alcántara
2004-2019
Universidad de Navarra
2019
Hospital Universitario Virgen de la Arrixaca
2019
Triple negative breast cancer (TNBC) is a heterogeneous disease with distinct molecular subtypes that differentially respond to chemotherapy and targeted agents. The purpose of this study explore the clinical relevance Lehmann TNBC by identifying any differences in response neoadjuvant among them. We determined gene expression profiling paraffined pre-treatment tumor biopsies from 125 patients treated anthracyclines and/or taxanes +/- carboplatin. explored clinicopathological characteristics...
Studies of neoadjuvant chemotherapy regimens using anthracyclines followed by taxanes have reported a doubling pathological complete remission (pCR) rates compared with anthracycline-based alone. A reverse sequence did not reduce activity. Nab-paclitaxel is an albumin-bound nanoparticle paclitaxel that allows for safe infusion without premedication, and its use led to significantly higher rate pCR in the GeparSepto trial.To determine whether nab-paclitaxel improves outcomes early locally...
Palbociclib plus endocrine therapy (ET) is the standard treatment of hormone receptor-positive and human epidermal growth factor receptor 2-negative, metastatic breast cancer (MBC). However, its efficacy has not been compared with that chemotherapy in a phase III trial.PEARL multicentre, randomised study which patients aromatase inhibitor (AI)-resistant MBC were included two consecutive cohorts. In cohort 1, 1 : to palbociclib exemestane or capecitabine. On discovering new evidence about...
In this study, we evaluated the ability of gene expression profiles to predict chemotherapy response and survival in triple-negative breast cancer (TNBC).
Background According to the "World Cancer Research Fund" and "American Institute of Research" (WCRF/AICR) one in four cancer cases could be prevented through a healthy diet, weight control physical activity. Objective To explore association between WCRF/AICR recommendations risk breast cancer. Methods During period 2006 2011 we recruited 973 incident controls from 17 Spanish Regions. We constructed score based on 9 for prevention:: 1)Maintain adequate body weight; 2)Be physically active;...
Self-expandable metal stents were inserted in cancer patients with superior vena cava (SVC) syndrome to assess their effectiveness as a primary treatment for symptom relief.Between January 1993 and June 2008, Wallstent prostheses (n = 208) 149 (137 men, 12 women; median age, 65 years; age range, 44-84 years) diagnosed having SVC syndrome. A single stent was sufficient restore vessel patency 102 patients, two 36, three 10, four one. Survival data calculated using Kaplan-Meier curves...
The objective of this study was to determine the conversion rate human epidermal growth factor receptor 2 (HER2), estrogen (ER) and progesterone (PR) between primary tumors metastatic lesions in advanced breast cancer. Patients with suspected diagnosis locally recurrent or cancer, either at first relapse after successive disease progressions, who had an appropriately preserved sample from a tumor were scheduled for biopsy lesion, included. Blinded determinations status on paired samples...
Adding taxanes to anthracycline-based adjuvant therapy improves survival outcomes of patients with node-positive breast cancer (BC). Currently, however, most BC are node negative at diagnosis. The only pure node-negative study (Spanish Breast Cancer Research Group 9805) reported so far showed a docetaxel benefit but significant toxicity. Here we tested the efficacy and safety weekly paclitaxel (wP) in patients, which is yet be established.Patients having T1-T3/N0 tumors least one high-risk...
In the neoadjuvant setting, changes in proliferation marker Ki67 are associated with primary endocrine treatment efficacy, but its value as a predictor of response to chemotherapy is still controversial.We analyzed 262 patients centralized basal immunohistochemical evaluation derived from 4 GEICAM (Spanish Breast Cancer Group) clinical trials for breast cancer. The objective was identify optimal threshold using receiver-operating characteristic curve method maximize predictive benefit. We...
Abstract Purpose To evaluate the efficacy and safety of first-line therapy with palbociclib in a Spanish cohort treated after approval. Methods PALBOSPAIN is an observational, retrospective, multicenter study evaluating real-world patterns outcomes 1 L men women (any menopausal status) advanced HR + /HER2– BC diagnosed between November 2017 2019. The primary endpoint was progression-free survival (rw-PFS). Secondary endpoints included overall (OS), response rate (rw-RR), clinical benefit...
Abstract Introduction Stroke models are based on permanent or transient occlusion of cerebral arteries. Despite model tends to produce more variable results, it can investigate reperfusion. Although ischemia-reperfusion is well established in rat using a silicone-filament by exposition carotid artery, the endovascular approach large animal still challenge. The purpose was develop novel rabbit an intraluminal wire means and subsequent assessed MRI. Methods Four New Zealand rabbits (4-5 kg)...
A haemophilia-specific health-related quality-of-life questionnaire (named 'Hemofilia-QoL') was developed to assess in adults with haemophilia, and psychometrically tested. Seventy-three interviews haemophilia patients health care professionals were used generate the items included questionnaire, expert ratings on formulated screen them for potential omission. This followed by psychometric testing a sample of 35 patients. Preliminary revised version, which contains 10 domains (physical...
Hormone receptor-positive (HR
This study analyzes the association of excessive energy intake and caloric restriction with breast cancer (BC) risk taking into account individual needs Spanish women. We conducted a multicenter matched case-control where 973 pairs completed lifestyle food frequency questionnaires. Expected was predicted from linear regression model in controls, including calories consumed as dependent variable, basal metabolic rate an offset physical activity explanatory. Overeating were defined 99%...
Derived neutrophil-to-lymphocyte ratio (dNLR) is a biomarker associated with clinical outcome in breast cancer (BC). We analyzed the association of dNLR pathological complete response (pCR) triple-negative BC (TNBC) patients receiving neoadjuvant chemotherapy (CT).This retrospective analysis two randomized studies involving early stage/locally advanced TNBC anthracycline/taxane-based CT+/-carboplatin (GEICAM/2006-03) or nab-paclitaxel/paclitaxel followed by anthracycline regimen (ETNA). was...
Abstract Author Summary Background. The approved capecitabine regimen as monotherapy in metastatic breast cancer (MBC) is 1,250 mg/m2 twice daily for 2 weeks on and 1 week off (Cint). Dose modifications are often required because of severe hand-foot syndrome (HFS). We tested a continuous with lower dose but similar cumulative an attempt to reduce the severity adverse events (AEs) while maintaining efficacy. Methods. randomized 195 patients HER-2/neu-negative MBC 800 throughout 21-day cycle...