A5002434210- Nursing care and research
- Central Venous Catheters and Hemodialysis
- Chemotherapy-related skin toxicity
- Palliative and Oncologic Care
- Cancer Treatment and Pharmacology
- Health and Medical Education
- Nutrition and Health in Aging
- Venous Thromboembolism Diagnosis and Management
- Musculoskeletal pain and rehabilitation
- Palliative Care and End-of-Life Issues
- Spinal Fractures and Fixation Techniques
- Hair Growth and Disorders
- Cancer survivorship and care
- Ethics and bioethics in healthcare
- Health Education and Validation
- COVID-19 and healthcare impacts
- Economic and Financial Impacts of Cancer
- Vascular Procedures and Complications
- Childhood Cancer Survivors' Quality of Life
- Medical research and treatments
- Patient Safety and Medication Errors
- Patient-Provider Communication in Healthcare
- Esophageal and GI Pathology
- Spanish History and Politics
- Infrared Thermography in Medicine
Comillas Pontifical University
2016-2025
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2018-2020
Centro de Investigación Biomédica en Red de Cáncer
2018
Hospital Clínico San Carlos
2013-2018
PharmacoGenetics (China)
2014
University of Buenos Aires
2008
•The number of new cancer patients decreased 20.8%•Assistance protocols were adapted•Inclusion in clinical trials by 12.9% BackgroundStudies evaluating the effects COVID-19 pandemic on public healthcare systems are limited, particularly management. As no such studies have been carried out Spain, our objective is to describe and quantify impact Spanish hospitals during first wave pandemic.Materials methodsThis retrospective, multicenter, nationwide study collected information from hospital...
Malnutrition is a prevalent condition in cancer patients that significantly impacts patients' clinical outcomes and health-related quality of life (HR-QoL). The outcome was to characterize the nutritional status by describing prevalence malnutrition (mild, moderate, or severe) its risk outpatient patients. Multicenter, prospective, cross-sectional, descriptive, two-cohort study conducted on consecutive adult with locally advanced metastatic solid tumors (stages III-IV). 10 Spanish hospitals...
Abstract Background Persistent alopecia (PA) after docetaxel has been recently described. The aim of our study is to establish the incidence and characteristics PA following adjuvant for breast cancer (BC) test ability scalp cooling in prevention. Patients methods BC patients receiving chemotherapy followed or not by endocrine therapy (and a control group only therapy) were interviewed single institution at 1.5 5 years primary diagnosis searching PA. A confirmatory prevalence was later...
Abstract Author Summary Background. The approved capecitabine regimen as monotherapy in metastatic breast cancer (MBC) is 1,250 mg/m2 twice daily for 2 weeks on and 1 week off (Cint). Dose modifications are often required because of severe hand-foot syndrome (HFS). We tested a continuous with lower dose but similar cumulative an attempt to reduce the severity adverse events (AEs) while maintaining efficacy. Methods. randomized 195 patients HER-2/neu-negative MBC 800 throughout 21-day cycle...
Purpose VIA scale is a dynamic performance status tool of the peripheral venous system that divided into five different grades, composed three parameters: number observable puncture points; optimal catheter size for cannulation and ease performing venipuncture risk extravasation. Methods Prospective single-center, observational, open, non-randomized study two phases. In first longitudinal phase, we studied clinical characteristics changes in their systems during intravenous chemotherapy 16...
Objective: To determine the prevalence of difficult venous access in adult patients admitted to a surgical unit. Method: This observational prospective cohort study included 235 from Brazilian hospital. Clinical data were collected by direct observation and analyzed descriptive, inferential statistics, multiple binomial logistic regressions. Odds ratios also calculated. Results: Most (66.4%) men self-reported as white (59.2%). The intravenous was 32.8%. Predictors peripheral cannula...
Background Communication is one of the central axes around which end-of-life care revolves in context palliative care. bad news reported as most difficult and stressful tasks by professionals. Therefore, aim this study to identify aspects related communication Spain. Methods Descriptive cross-sectional study. An ad hoc questionnaire was designed sent e-mail all teams Results Overall, 206 professionals (102 nurses, 88 physicians 16 psychologists) completed questionnaire. A total 60.2%...
Patients with cancer can experience bone metastases and/or treatment–induced loss (CTIBL), and the resulting complications place burdens on patients healthcare provision. Management of is becoming increasingly important as survival rates improve. Advances in specialist oncology nursing practice benefit through better management their health, which may improve quality life survival. An anonymised online quantitative survey asked nurses about factors affecting provision support CTIBL. Of 283...
Objective A primary challenge in identifying replicable pharmacogenomic markers from clinical genomewide association study (GWAS) trials oncology is the difficulty performing a second large trial with same drugs and dosage regimen. We sought to overcome this by incorporating GWAS results cell-based studies using chemotherapy as cohort. Methods In study, we test whether overlap between genetic variants identified preclinical on capecitabine more than expected chance. of capecitabine-induced...
Persistent chemotherapy-induced alopecia (pCIA) has been recently described in patients with breast cancer and its most severe form occurs up to 10% of these patients. Genetic risk factors associated pCIA have not adequately explored.To identify genetic variants pCIA.In this association study, 215 women treated docetaxel-based chemotherapy a follow-up 1.5 10 years after the end treatment were recruited retrospectively through 3 hospital oncology units across Spain between 2005 2018. Severe...
Abstract Background Cancer-related fatigue is a prevalent condition in all stages of oncologic disease that poorly diagnosed, with negative impact on physical function to perform activities daily living. Fatigue also one the main manifestations post-COVID-19 syndrome, and few studies have explored functionality cancer patients after infection by new coronavirus. This study was designed assess cancer-related symptoms their implications quality life during pandemic. Methodology An...
Abstract Purpose Cancer patients require implantation of venous access devices to meet their personalized therapeutic needs, which are often complex due the nature medication and disease status. Therefore, it is essential have standardized protocols that guarantee best results in health patient safety. Methods To learn about availability aspects related safety clinical practice detect possible opportunities for improvement, a survey has been conducted various Spanish hospitals, addition...
ResumoEnquadramento: Um número significativo de pessoas adultas tem um acesso venoso periférico difícil, o que leva a múltiplas tentativas punção e ao esgotamento da rede venosa.A escala Venous International Assessment (VIA) é considerada nível internacional como instrumento fiável classifica as vias das determina risco complicações associadas.Objetivos: Traduzir, adaptar culturalmente validar Escala VIA para português europeu.Metodologia: Estudo tradução, adaptação cultural, avaliação...
Capecitabine-induced hand-foot syndrome (CiHFS) is a common dermatological adverse reaction affecting around 30% of patients with capecitabine-treated cancer, and the main cause dose reductions chemotherapy delays. To identify novel genetic factors associated CiHFS in we carried out an extreme-phenotype genomewide association study 166 breast colorectal cancer replication second cohort 85 patients. We discovered replicated cluster four highly correlated single-nucleotide polymorphisms...
Neuromuscular electrostimulation (NMES) has been used mainly as a method to promote muscle strength, but its effects on improving blood flow are less well known. The aim of this study is deepen the knowledge about local and contralateral application symmetric biphasic square currents skin temperature (Tsk). An experimental pilot was developed with single group consisting 45 healthy subjects. Thermographic evaluations were recorded following NMES anterior region thigh. results showed an...
Background: Pediatric palliative cares involve the whole family, along with interdisciplinary pediatric care (PPC) team. The commitment of PPC team and engagement family at different levels can play a key role in advancing better quality life children families. Method: A descriptive pre-post educational intervention study was carried out. creation training program (with term “school” used to denote this effort) strives prepare caretakers master skills as well provide support for serious...
The technological transformation and advertising utilized in the footwear industry significantly impact purchasing decisions. gait properties, barefoot with shoes, change depending on structure. aim of this work is biomechanical analysis walking different sports shoes a controlled group 12 children between 4 6 years old. Kinematic spatiotemporal variables were analyzed using BTS motion capture system Helen Hayes protocol. Previously, survey was carried out 262 families old to justify choice...
Taxanes and anthracyclines are widely used in the treatment of breast cancer, although benefit is limited to a proportion patients predictive biomarkers for clinical outcome remain elusive.We carried out pharmacogenetic study 181 with locally advanced cancer enrolled phase 2 randomized trial (NCT00123929), where were randomly assigned receive neoadjuvant single-agent docetaxel 100 mg/m(2) (n=84) or doxorubicin 75 (n=97). We studied association 226 single nucleotide polymorphisms (SNPs) 15...
ABSTRACT Objective: To validate the Brazilian Portuguese translation and analyze cultural adaptation of Venous International Assessment Scale. Methods: Observational study by employing Delphi technique an equivalence evaluation experts. The results were analyzed using item scores content validity index calculations item, scale, universal agreement. Results: Three rounds necessary for consensus. Explanatory contents incorporated into original scale throughout process, resulting in a new...
RESUMO Objetivo: realizar a adaptação transcultural e análise das propriedades métricas da Adult Difficult Intravenous Access Scale para o português do Brasil. Método: estudo metodológico, realizado de fevereiro 2021 abril 2023, em Minas Gerais, Brasil, duas etapas: 1) Tradução escala versão original inglês brasileiro, avaliação por comitê composto nove juízes, retrotradução semântica; 2) Análise com 130 adultos admitidos uma unidade hemodinâmica que se verificou ocorrência punção venosa...
ABSTRACT Objective: to cross-culturally adapt and analyze the metric properties of Adult Difficult Intravenous Access Scale into Brazilian Portuguese. Method: methodological study carried out in two stages: 1) Translation scale from original version English Portuguese, including an assessment by a committee nine judges, back-translation semantic analysis; 2) Analysis with 130 adults admitted hemodynamics unit which difficult peripheral venipunctures occurred. Participants were followed up...
to translate and validate Spanish the Caring Assessment Scale tool, CAT-V, by Joanne Duffy, within framework of Jean Watson; as a secondary objective, it is proposed evaluate its psychometric properties. There are tools designed measure patient's perception provided cares, including subject our interest, in way that can be used Spanish-speaking patients.