A5043367500- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Cardiac Valve Diseases and Treatments
- ECG Monitoring and Analysis
- Pericarditis and Cardiac Tamponade
- Functional Brain Connectivity Studies
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Function and Risk Factors
Case Western Reserve University
2013-2024
University Hospitals of Cleveland
2020
Uijeongbu St. Mary's Hospital
2017
Catholic University of Korea
2017
Cleveland Research (United States)
2015
Valve (United States)
2015
University Hospitals Cleveland Medical Center
2015
Background— The mechanism(s) of persistent and long-standing (LSP) atrial fibrillation (AF) is/are poorly understood. We performed high-density, simultaneous, biatrial, epicardial mapping LSP AF in patients undergoing open heart surgery (1) to test the hypothesis that are due ≥1 drivers, either focal or reentrant, (2) characterize associated activation. Methods Results— Twelve with (1 month 9 years duration) were studied at surgery. During AF, electrograms recorded from both atria...
Moe et al. hypothesized that multiple wavelets (random reentry) were the mechanism of atrial fibrillation (AF) based on studies in a vagal nerve stimulation (VNS) canine model and computer AF, but mapping during AF this has not been done. We restudied using high density, simultaneous site to test hypothesis was due wavelets.During pacing induced VNS 10 dogs, 512 unipolar electrograms recorded simultaneously from both atria. activation maps produced including through termination after...
We previously demonstrated that persistent and long-standing atrial fibrillation is maintained by activation emanating from foci breakthrough sites of different cycle lengths (CLs). The purpose this study was to characterize the behavior focal nonrandom identified during high-density mapping in these patients.During open heart surgery, we recorded both atria simultaneously using 510 512 epicardial electrodes along with ECG lead II 12 patients fibrillation. For each patient, analysis 32...
AF Cycle Length Detection Analysis . Introduction: Experimental models have demonstrated that atrial fibrillation (AF) may be due to one or more rapid drivers (source) producing AF. These characterized by and regular cycle lengths (CLs), fibrillatory conduction the rest of atria. The ability reliably identify such would invaluable. purpose this study was develop validate a CL variability detection (CLVD) analysis capable accurately determining beat‐to‐beat CLs electrograms (AEGs) during AF,...
Determining the sequence of activation is a major source information for understanding electrophysiological mechanism(s) atrial fibrillation (AF). However, complex morphology electrograms hampers their analysis, and has stimulated generations electrophysiologists to develop large variety technologies recording, pre-processing, analysis electrograms. This variability approaches mirrored by in interpretation and, thereby, opinions regarding basic AF vary widely. Multiple wavelets, different...
Abstract Introduction Postoperative atrial fibrillation (POAF) is common following open heart surgery, and associated with significant morbidity. Medications used for ventricular rate control of POAF may not be effective in controlling rapid rates during the postoperative period because increased sympathetic tone. The purpose this study was to develop nonpharmacologic by atrioventricular node (AVN) fat pad stimulation using clinically available temporary pacing wires canine sterile...
AimsPostoperative atrial fibrillation (POAF), new-onset AF after open heart surgery (OHS), is thought to be related pericarditis. Based on studies in the canine sterile pericarditis model, we hypothesized that POAF patients OHS may associated with a rapid, regular rhythm left atrium (LA), suggestive of an LA driver maintaining AF. The aim this study was test hypothesis POAF, electrograms (AEGs) recorded from at least one two carefully selected sites would manifest AEGs short cycle length...
We have identified a reentrant circuit in the pulmonary vein region, which drives atria, producing fibrillatory conduction, as one mechanism of postoperative atrial fibrillation (POAF) canine sterile pericarditis model.In this model, we tested hypothesis that overdrive pacing from site at or near such would interrupt it and thereby terminate POAF.We studied 11 dogs on days 1-4. Atrial electrograms (AEGs) were recorded during POAF, pacing, pace termination 3 sites simultaneously: Bachmann's...
Background This study assessed the effect of blockading neural transmission in ganglionated plexi by injecting lidocaine into fat pads vagal nerve stimulation canine model and patients with persistent atrial fibrillation ( AF ). Methods Results An efficacy test injection was performed 7 canines. During stimulation, sustained for >5 minutes. The injected during sinus rhythm reinduction attempted. Six were studied at open heart surgery. Lidocaine plexi. Atrial electrograms recorded from 96...
Abstract Background The canine sterile pericarditis model associated with atrial inflammation is an experimental counterpart of postoperative fibrillation (POAF). However, the use canines for research restricted by ethics committees in many countries, and social acceptance declining. Objective To validate feasibility swine as to study POAF. Methods Seven domestic pigs (35–60 kg) underwent initial surgery. On two or more days closed‐chest state, we performed electrophysiological measurements...
Background: Phase analysis has been used to identify and localize atrial fibrillation (AF) sources for targeted ablation. We previously demonstrated that repetitive wannabe reentry (incomplete reentry) often generated an apparent stable rotor using phase analysis. The misinterpretation caused by electrograms (AEGs) may result from detecting inaccurate time points at inversion (π −π) in the instantaneous waveform converted AEG. purpose of this study was evaluate accuracy detect activations...