A5040451692- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Nutritional Studies and Diet
- Cancer Risks and Factors
- Estrogen and related hormone effects
- BRCA gene mutations in cancer
- Lung Cancer Treatments and Mutations
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related Molecular Pathways
- Breast Implant and Reconstruction
- Cancer Cells and Metastasis
- Computational Drug Discovery Methods
- Hedgehog Signaling Pathway Studies
- Global Cancer Incidence and Screening
- Breast Lesions and Carcinomas
- Cancer Immunotherapy and Biomarkers
- Cancer survivorship and care
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cardiac tumors and thrombi
- Radiopharmaceutical Chemistry and Applications
- Cancer Diagnosis and Treatment
Complexo Hospitalario Universitario A Coruña
2016-2025
Instituto de Investigación Biomédica de A Coruña
2009-2025
GEICAM – Spanish Breast Cancer Group
2013-2024
Hospital Universitario 12 De Octubre
2024
Universidade da Coruña
2009-2023
Hospital Clínico Universitario Lozano Blesa
2022
Servicio Gallego de Salud
2015-2020
Hospital Clínico Universitario de Valencia
2011-2018
Hospital Virgen de la Salud
2011-2018
Centro de Investigación Biomédica en Red
2018
Abstract Biological changes that occur during metastatic progression of breast cancer are still incompletely characterized. In this study, we compared intrinsic molecular subtypes and gene expression in 123 paired primary tissues from patients. Intrinsic subtype was identified using a PAM50 classifier χ2 tests determined the differences variable distribution. The rate conversion 0% basal-like tumors, 23.1% HER2-enriched (HER2-E) 30.0% luminal B 55.3% A tumors. 40.2% cases, tumors converted...
Triple negative breast cancer (TNBC) is a heterogeneous disease with distinct molecular subtypes that differentially respond to chemotherapy and targeted agents. The purpose of this study explore the clinical relevance Lehmann TNBC by identifying any differences in response neoadjuvant among them. We determined gene expression profiling paraffined pre-treatment tumor biopsies from 125 patients treated anthracyclines and/or taxanes +/- carboplatin. explored clinicopathological characteristics...
Although there are solid findings regarding the detrimental effect of alcohol consumption, existing evidence on other dietary factors breast cancer (BC) risk is inconclusive. This study aimed to evaluate association between patterns and BC in Spanish women, stratifying by menopausal status tumour subtype, compare results with those Alternate Healthy Index (AHEI) Mediterranean Diet Score (aMED). We recruited 1017 incident cases matched healthy controls similar age (±5 years) without a history...
Background According to the "World Cancer Research Fund" and "American Institute of Research" (WCRF/AICR) one in four cancer cases could be prevented through a healthy diet, weight control physical activity. Objective To explore association between WCRF/AICR recommendations risk breast cancer. Methods During period 2006 2011 we recruited 973 incident controls from 17 Spanish Regions. We constructed score based on 9 for prevention:: 1)Maintain adequate body weight; 2)Be physically active;...
Abstract Purpose CXCR1, one of the receptors for CXCL8, has been identified as a druggable target on breast cancer stem cells (CSC). Reparixin (R), an investigational oral inhibitor was safely administered to metastatic patients in combination with paclitaxel (P) and appeared reduce CSC window-of-opportunity trial operable cancer. The fRida (NCT02370238) evaluated addition R weekly first-line therapy (m) TNBC. Subjects Methods untreated mTNBC were randomized 1:1 or placebo days 1–21 P 80...
The deregulation of microRNAs in both tumours and blood has led to the search for indicate presence cancer predict prognosis. We hypothesize miR-200c/miR-141 whole can identify breast (BC), could be developed into a prognostic signature. expression miR-200c miR-141 were examined bloods (57 stage I-IV BC patients 20 age-matched controls) by quantitative reverse-transcription PCR. associations circulating with clinic pathological characteristics analysed. Their effects on survival analysed...
The objective of this study was to determine the conversion rate human epidermal growth factor receptor 2 (HER2), estrogen (ER) and progesterone (PR) between primary tumors metastatic lesions in advanced breast cancer. Patients with suspected diagnosis locally recurrent or cancer, either at first relapse after successive disease progressions, who had an appropriately preserved sample from a tumor were scheduled for biopsy lesion, included. Blinded determinations status on paired samples...
This multicenter phase II trial evaluated lurbinectedin (PM01183), a selective inhibitor of active transcription protein-coding genes, in patients with metastatic breast cancer. A unicenter translational substudy assessed potential mechanisms resistance.Two arms were according to germline BRCA1/2 status: mutated (arm A; n = 54) and unselected ( wild-type or unknown status; arm B; 35). Lurbinectedin starting dose was 7-mg flat later, 3.5 mg/m2 A. The primary end point objective response rate...
SASCIA (NCT04595565) is an ongoing phase III study randomising patients (pts) with HER2- BC and residual disease after neoadjuvant chemotherapy (NACT) or hormone receptor (HR)+ a CPS+EG score ≥3 2 ypN+ NACT to SG treatment of physicianś choice (TPC, capecitabine, platinum, observation). We present the results pre-planned SIA. The analysis was performed first 50 randomized pts had completed 4 therapy cycles. Pts were included if they received ≥2 cycles, observed ≥6 wks discontinued earlier....
Objective: To evaluate the differences in overall survival (OS) and progression-free (PFS) between men women with non-small-cell lung cancer (NSCLC) treated immune checkpoint inhibitors (ICIs) second-line later treatments. Methods: A retrospective, single-center observational study was conducted on patients advanced NSCLC ICIs (nivolumab, pembrolizumab, atezolizumab) from January 2015 to December 2019 (with follow-up until 2021). Demographic, clinical, treatment-related variables were...
Abstract Purpose The primary aim of NSABP FB-7 was to determine the pathologic complete response (pCR) rate in locally advanced HER2-positive (HER2 + ) breast cancer patients treated with neoadjuvant trastuzumab or neratinib combination and weekly paclitaxel followed by standard doxorubicin plus cyclophosphamide. secondary aims include biomarker analyses. Experimental design pCR tested for association treatment, gene expression, a single nucleotide polymorphism (SNP) Fc fragment IgG receptor...
Abstract Background Whether there are lifetime points of greater sensitivity to the deleterious effects alcohol intake on breasts remains inconclusive. Objective To compare influence distinctive trajectories consumption throughout a woman’s life development breast cancer (BC). Methods 1278 confirmed invasive BC cases and matched (by age residence) controls from Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used identify different women’s lifetime. Results...
Abstract Background: CDK7 has 3 critical roles in cancer: enhanced transcription of oncogenes and upregulation anti-apoptotic genes, acceleration the cell cycle through phosphorylation other CDKs driving estrogen receptor (ER) resistance to hormonal therapy. Inhibition is therefore a potential novel anti-cancer therapeutic strategy. Samuraciclib (CT7001), once daily oral inhibitor demonstrated favorable safety profile clinical activity combination with fulvestrant (SERD) patients HR+/HER2-...
This study analyzes the association of excessive energy intake and caloric restriction with breast cancer (BC) risk taking into account individual needs Spanish women. We conducted a multicenter matched case-control where 973 pairs completed lifestyle food frequency questionnaires. Expected was predicted from linear regression model in controls, including calories consumed as dependent variable, basal metabolic rate an offset physical activity explanatory. Overeating were defined 99%...