A5047358403- Taxation and Legal Issues
- Corporate Taxation and Avoidance
- Herpesvirus Infections and Treatments
- Neuroblastoma Research and Treatments
- Bacterial Infections and Vaccines
- Advanced Breast Cancer Therapies
- Cancer, Hypoxia, and Metabolism
- Pneumonia and Respiratory Infections
- Acne and Rosacea Treatments and Effects
- Urticaria and Related Conditions
- Economic and Fiscal Studies
- HER2/EGFR in Cancer Research
- Cancer-related Molecular Pathways
- Bartonella species infections research
- Statistical Methods in Clinical Trials
- Pneumocystis jirovecii pneumonia detection and treatment
- Ethics in Clinical Research
- Fiscal Policy and Economic Growth
- Lung Cancer Research Studies
- Psychoanalysis and Social Critique
- Adolescent and Pediatric Healthcare
- Taxation and Compliance Studies
- German legal, social, and political studies
- Cell death mechanisms and regulation
- Child and Adolescent Health
Austrian Breast & Colorectal Cancer Study Group
2021-2025
MorphoSys (Germany)
2021-2022
GlaxoSmithKline (Germany)
2020-2022
St. Anna Children's Cancer Research Institute
2015
St Anna Children's Hospital
2015
Several chronic underlying conditions (UCs) are known to be risk factors for developing herpes zoster (HZ) and increase the severity of HZ its recurrence. The aim this study was investigate incidence recurrence in adult patients with one or multiple UCs.A retrospective cohort based on claims data representing 13% statutory health insurance population from 2007 2018 Germany performed. Patients aged ≥ 18 years were included when at least following UCs diagnosed: asthma, heart failure,...
// Sabine Taschner-Mandl 1 , Magdalena Schwarz Johanna Blaha Maximilian Kauer Florian Kromp Nelli Frank Fikret Rifatbegovic Tamara Weiss Ruth Ladenstein 1, 2 Martin Hohenegger 3 Inge M. Ambros Peter F. CCRI, Chlidren's Cancer Research Institute, Vienna, Austria Department of Pediatrics, Medical University Center for Physiology and Pharmacology, Correspondence to: Taschner-Mandl, e-mail: sabine.taschner@ccri.at Keywords: senescence-associated-secretory-phenotype, metronomic, topotecan,...
The aim of the study was to update previously published public health impact and cost-effectiveness analyses recombinant zoster vaccine (RZV), in German population aged ≥50 years age (YOA), with latest efficacy (VE) estimates against herpes (HZ). updated are derived from a long-term follow-up study. A multi-cohort Markov model following cohorts over their lifetime used. Demographic, epidemiological, cost, utility data were based on specific sources. Vaccine coverage assumed be 40%, second...
Summary Clinical trials are subject to an ever-evolving landscape of treatment options, regulatory requirements, socioeconomic conditions, and paradigms scientific research. In this opinion paper, we illustrate current methods topics with a focus on clinical trial designs, conduct modes collaboration. The example successful breast cancer research in Austria demonstrates the opportunities, but also challenges for academic We investigate potential pitfalls, suggest new ideas strategies how...
Invasive meningococcal disease (IMD) is an uncommon, severe, life-threatening primarily affecting infants, with potential lifelong sequelae. Neisseria meningitidis (Nm) serogroup B (MenB) causes most IMD cases in Germany, many of which can be prevented four-component MenB (4CMenB) vaccination. The public health and economic impact introducing routine 4CMenB infant vaccination Germany was assessed. A dynamic transmission-based cost-effectiveness model adapted for assessed the universal mass...
We propose a user-driven method for the segmentation of neuroblastoma nuclei in microscopic fluorescence images involving gradient energy tensor . Multispectral contain intensity and spatial information about antigene expression, situ hybridization (FISH) signals nucleus morphology. The latter serves as basis detection single cells calculation shape features, which are used to validate reject false detections. Accurate is difficult due varying staining intensities aggregated cells. It...
Abstract Background: Poor prognosis and frequent relapses are major challenges for patients with high-risk neuroblastoma (NB), especially when tumors show MYCN amplification. High-dose chemotherapy triggers apoptosis, necrosis, senescence, a cellular stress response leading to permanent proliferative arrest typical senescence-associated secretome (SASP). SASP components reinforce growth act in an immune-stimulatory fashion, while others tumor promoting. Studies on low-dose long-term, i.e.,...