A5078424810- Breast Cancer Treatment Studies
- Reconstructive Facial Surgery Techniques
- Advanced Breast Cancer Therapies
- Nerve Injury and Rehabilitation
- Facial Rejuvenation and Surgery Techniques
- Platelet Disorders and Treatments
- HER2/EGFR in Cancer Research
- Facial Nerve Paralysis Treatment and Research
- Medical Imaging Techniques and Applications
- Neurogenetic and Muscular Disorders Research
- Eosinophilic Esophagitis
- RNA modifications and cancer
- Complement system in diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Lymphoma Diagnosis and Treatment
- Thermoregulation and physiological responses
- RNA and protein synthesis mechanisms
- Peripheral Nerve Disorders
- Reconstructive Surgery and Microvascular Techniques
- Orthopedic Surgery and Rehabilitation
- Cardiac Valve Diseases and Treatments
- Neurobiology and Insect Physiology Research
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Pregnancy and Medication Impact
Medical University of Vienna
2019-2025
Comprehensive Cancer Center Vienna
2020-2025
Sensing of noxious heat has been reported to be mediated by TRPV1, TRPA1, TRPM3, and ANO1 in mice, this is redundant so that the loss one receptor at least partially compensated for others. We have established an infusion-based human pain model. Heat-induced probed with antagonists four receptors did not match redundancy found mice. In healthy participants, only TRPV1 contributes detection heat; none other three are involved. inhibition reduced all temperatures, which can also seen as...
Abstract OBJECTIVES The anatomical distribution pattern of epidural intraspinal arteries is not entirely understood but likely to substantially impact maintaining perfusion during segmental artery sacrifice when treating acute and chronic thoraco-abdominal aortic diseases. We investigated the arteries. METHODS Twenty fresh, non-embalmed cadaveric human bodies were studied. Anatomical dissection investigation arterial network performed according a standardized protocol. used generalized mixed...
Phosphatidylinositol 3-kinase catalytic subunit p110β is involved in tumorigenesis and hemostasis. However, it remains unclear if also regulates platelet-mediated immune responses, which could have important consequences for modulation during anti-cancer treatment with inhibitors. Thus, we investigate how platelet affects inflammation infection. Using a mouse model of Streptococcus pneumoniae-induced pneumonia, find that both platelet-specific deficiency pharmacologic inhibition TGX-221...
Key Points Platelets contain virus-specific IgGs that potently diminish viral infection in vitro and vivo. Release of platelet IgG is more efficient at virus neutralization than equal amounts plasma IgG.
Abstract Background The profunda femoris artery perforator (PAP) flap is gaining popularity in microsurgical reconstruction. To establish a safer elevation technique, we focused on the topology of accessory saphenous vein medial thigh area. We hypothesize that including PAP results transfer with two venous drainage systems. aim this study was to describe anatomical relationship between perforators and using fresh cadavers through clinical cases. Methods For study, 19 posterior regions from...
Abstract Reliable determination of Ki67 labeling index (Ki67-LI) on core needle biopsy (CNB) is essential for determining breast cancer molecular subtype therapy planning. However, studies agreement between and Ki67-LI CNB surgical resection (SR) specimens are conflicting. The present study analyzed the influence clinicopathological sampling-associated factors agreement. Molecular was determined visually by in 484 pairs SR invasive estrogen receptor (ER)–positive, human epidermal growth...
Frozen section (IFS) assessment enables intraoperative of resection margins, however, its accuracy is subjected to interobserver variability. This study evaluated factors that affect efficacy margin evaluation using IFS in a cohort breast cancer patients and impact on disease free overall survival. All presenting with primary operable carcinoma who received between 2016 2018 at the Breast Health Centre Medical University Vienna were included study. Patients standard adjuvant treatment as...
Abstract The present study evaluated whether Prosigna® breast cancer assay intrinsic subtype (IST) can be predicted using a specified cutoff for Ki67 proliferation index and immunohistochemical (IHC) biological estimation, complemented by estrogen receptor (ER) progesterone (PR) expression in clinical cohort. Our included 185 cases of early stage ER-positive, HER2-negative treated at the Comprehensive Cancer Center Medical University Vienna between 2014 2019. was performed when recommended...
For cubital tunnel syndrome, the avoidance of predisposing arm positions and use elbow splints are common conservative treatment options. The rationale is to prevent excessive stretching compression nerve in tunnel, as this mechanical stress impedes intraneural perfusion. Data regarding those upper extremity postures avoid, or whether flexion alone detrimental, inconsistent. This study aimed assess perfusion size changes during different an experimental cadaver setup.Axillary arteries 30...
Abstract Background: Immune checkpoint inhibitors such as PD-L1 are promising therapy targets in triple negative breast cancer (TNBC). In the present study, we examined clinical relevance of and CD8 expression TNBC patients treated with adjuvant chemotherapy. Methods: FFPE tumor material from 118 early between 1999 2012 was included our analysis. Immunohistochemical (IHC) determined by immune score using diagnostic antibody SP142 (Ventana). IHC performed SP57 Follow-up data were available...
Background The temporalis muscle flap transfer with fascia lata augmentation (FLA) is a promising method for smile reconstruction after facial palsy. International literature lacks detailed anatomical analysis of the (TPM) combined (FL) augmentation. This study aims to describe muscle's properties and calculate length FL needed perform FLA. Methods Twenty nonembalmed male (m) female (f) hemifacial cadavers were dissected investigate anatomy. Results calculated minimum 7.03cm 5.99cm (m)....
Spinal muscular atrophy is one of the most common severe inherited diseases in childhood and especially acute form type I (Werdnig-Hoffmann) results early death. Recently, all three types childhood-onset SMA have been mapped to chromosome 5. Since then heterozygote detection siblings prenatal diagnosis possible by indirect genetic analysis. As gene mutation responsible for disease not yet cloned, DNA analysis a risk figure which depends on informativity recombination frequency flanking...
Abstract Data on the accuracy of intraoperative resection margin assessment and its influence survival after neoadjuvant therapy (NT) are scarce. In present study, we analyzed by frozen section (IFS) in prospectively randomized clinical trials ABCSG 24 34.164 patients with early breast cancer who received NT within 34 between 2005 2015, IFS were included our analysis. Resection status was compared to subsequent FFPE status, which considered gold standard. According rate FFPE-based...