A5048283423- Breast Cancer Treatment Studies
- Global Cancer Incidence and Screening
- Cancer survivorship and care
- Nutritional Studies and Diet
- Cancer Risks and Factors
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Estrogen and related hormone effects
- BRCA gene mutations in cancer
- Patient-Provider Communication in Healthcare
- Cancer, Lipids, and Metabolism
- Economic and Financial Impacts of Cancer
- Pharmaceutical Practices and Patient Outcomes
- Palliative Care and End-of-Life Issues
- Women's cancer prevention and management
- Pancreatic and Hepatic Oncology Research
- Cancer-related cognitive impairment studies
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- Nutrition, Genetics, and Disease
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Peptidase Inhibition and Analysis
Hospital Universitario Puerta del Mar
2015-2024
Biomedical Research and Innovation Institute of Cadiz
2018-2024
GEICAM – Spanish Breast Cancer Group
2018-2024
Instituto de Investigación Biomédica de A Coruña
2022-2024
Harvard University
2018
Dana-Farber Cancer Institute
2018
Frontier Science & Technology Research Foundation
2018
Hospital Universitario Ramón y Cajal
2015
Pfizer (United States)
2015
Bristol-Myers Squibb (Germany)
2015
Although there are solid findings regarding the detrimental effect of alcohol consumption, existing evidence on other dietary factors breast cancer (BC) risk is inconclusive. This study aimed to evaluate association between patterns and BC in Spanish women, stratifying by menopausal status tumour subtype, compare results with those Alternate Healthy Index (AHEI) Mediterranean Diet Score (aMED). We recruited 1017 incident cases matched healthy controls similar age (±5 years) without a history...
Purpose Isolated locoregional recurrence (ILRR) predicts a high risk of developing breast cancer distant metastases and death. The Chemotherapy as Adjuvant for LOcally Recurrent (CALOR) trial investigated the effectiveness chemotherapy (CT) after local therapy ILRR. A report at 5 years median follow-up showed significant benefit CT estrogen receptor (ER)-negative ILRR, but additional was required in ER-positive Patients Methods CALOR an open-label, randomized patients with completely excised...
Operable triple-negative breast cancers (TNBCs) have a higher risk of relapse than non-TNBCs with standard therapy. The GEICAM/2003-11_CIBOMA/2004-01 trial explored extended adjuvant capecitabine after completion chemotherapy in patients early TNBC.Eligible were those operable, node-positive-or node negative tumor 1 cm or greater-TNBC, prior anthracycline- and/or taxane-containing chemotherapy. After central confirmation TNBC status by immunohistochemistry, randomly assigned to either...
Background According to the "World Cancer Research Fund" and "American Institute of Research" (WCRF/AICR) one in four cancer cases could be prevented through a healthy diet, weight control physical activity. Objective To explore association between WCRF/AICR recommendations risk breast cancer. Methods During period 2006 2011 we recruited 973 incident controls from 17 Spanish Regions. We constructed score based on 9 for prevention:: 1)Maintain adequate body weight; 2)Be physically active;...
Capecitabine is an active drug in metastatic breast cancer (BC). GEICAM/2003-10 adjuvant trial to investigate the integration of capecitabine into a regimen epirubicin and docetaxel for node-positive early BC.Patients with operable BC (T1-3/N1-3) were eligible. After surgery, 1,384 patients randomly assigned receive plus cyclophosphamide (EC; 90 600 mg/m(2), respectively, × four cycles), followed by (100 mg/m(2) cycles; EC-T) or (ET; 75 (1,250 twice day on days 1 14, ET-X); all regimens...
Abstract Background Whether there are lifetime points of greater sensitivity to the deleterious effects alcohol intake on breasts remains inconclusive. Objective To compare influence distinctive trajectories consumption throughout a woman’s life development breast cancer (BC). Methods 1278 confirmed invasive BC cases and matched (by age residence) controls from Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used identify different women’s lifetime. Results...
This study analyzes the association of excessive energy intake and caloric restriction with breast cancer (BC) risk taking into account individual needs Spanish women. We conducted a multicenter matched case-control where 973 pairs completed lifestyle food frequency questionnaires. Expected was predicted from linear regression model in controls, including calories consumed as dependent variable, basal metabolic rate an offset physical activity explanatory. Overeating were defined 99%...
In order to determine the feasibility of substituting pegylated liposomal doxorubicin (PLD) for in combination with cyclophosphamide and trastuzumab as adjuvant therapy, we conducted a phase II study first-line therapy human epidermal growth factor receptor 2 (HER2) overexpressing metastatic breast cancer (MBC).PLD 50 mg/m(2) 600 were administered every 4 weeks six cycles; (4 mg/kg loading dose, then mg/kg) was weekly 24 weeks. The primary end point objective response rate (ORR), secondary...
Medication reconciliation is considered to be an important strategy for increasing the safety of medication use. However, few studies have been carried out showing effect a program on incidence errors (REs) in oncological patients treated outpatient setting.To measure error that reached patient (RERP) cancer receiving chemotherapy as outpatients.A randomized, prospective, controlled study was identify proportion with at least 1 RERP. (intervention group) compared standard practice (control...
Background.Hospitals have traditionally been the place where follow-up of breast cancer patients occurs in Spain.
Participants in breast cancer screening programmes may benefit from early detection but also be exposed to the risks of overdiagnosis and false positives. We surveyed a sample Spanish women assess knowledge, information sources, attitudes psychosocial impact.A total 434 programme participants aged 45-69 years were administered questionnaires regarding impact. Scores 5 or more (out 10) 12 less 24) established as indicating adequate knowledge positive attitude, respectively. Psychosocial...
Abstract This study evaluates the impact of breast cancer (BC) in health related quality life (HRQL) and psychological distress (PD) during initial phases disease looks for contributing factors. A multicentric case-control study, EpiGEICAM, was carried out. Incident BC cases age- residence- matched controls were included. Clinical, epidemiological, HRQL (SF-36) PD information (GHQ-28) collected. We used multivariable logistic regression models to estimate OR low compared controls, identify...
Abstract Spanish women do not make an informed choice regarding breast cancer screening ( BCS ). Our aim was to evaluate the impact of receiving information real benefits and risks on knowledge, attitude, decision, feelings, worries about cancer. Randomized controlled clinical trial 355 aged between 45 67 years, 177 178 assigned intervention group IG ) control CG ), respectively. After screening, received either Nordic Cochrane Centre or standard information. The primary outcome (knowledge)...
This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle food frequency questionnaire was completed by 1017 BC cases healthy women pairs. Serum PL-FA percentages were measured gas chromatography-mass spectrometry. Conditional multinomial logistic regression models used to quantify the association tertiles risk,...
Adjuvant trastuzumab in HER2+ breast cancer reduces recurrence and mortality, has been the standard treatment since 2006. The objective was to analyze health outcomes real world. Observational, retrospective study of patients with cancer, stages I-III, treated adjuvant past 15 years only one center for first time Spain. Survival analyzed according number cycles cardiotoxicity. Two hundred seventy-five HER2positive (18.60%) out 1479 received (73%) or neoadjuvant/adjuvant (26%) trastuzumab,...
Background. Implementing mammogram screening means that clinicians are seeing many breast cancers will never develop metastases. The purpose of this study was to identify subgroups cancer patients who did not present events related long-term mortality, taking into account diagnosis at screening, absence palpability and axillary involvement, genomic analysis with PAM50. Patients Methods. To them, a retrospective observational carried out selecting without palpable tumour, performed Results....
Adherence to healthy lifestyle recommendations has been reported improve health-related quality of life (HRQL) in breast cancer (BC) patients, but the influence long-term behavioral changes remains unknown. We evaluated association between adherence 2018 World Cancer Research Fund/American Institute for (WCRF/AICR) prevention and HRQL both, at BC diagnosis change 7-12 years later.