A5008041383- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Delphi Technique in Research
- Pharmacological Effects of Natural Compounds
- Muscle Physiology and Disorders
- Nonmelanoma Skin Cancer Studies
- Economic and Financial Impacts of Cancer
- Ginger and Zingiberaceae research
- Clinical practice guidelines implementation
- Systemic Lupus Erythematosus Research
- Cutaneous lymphoproliferative disorders research
- Hedgehog Signaling Pathway Studies
- Nutrition and Health in Aging
- Health Systems, Economic Evaluations, Quality of Life
- Head and Neck Cancer Studies
- Spine and Intervertebral Disc Pathology
- Rheumatoid Arthritis Research and Therapies
- Global Cancer Incidence and Screening
- Mast cells and histamine
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Cutaneous Melanoma Detection and Management
- Connective tissue disorders research
- Hip disorders and treatments
- Cancer-related cognitive impairment studies
Hospital Universitario Fundación Jiménez Díaz
2015-2023
Universidad Autónoma de Madrid
2016-2023
United States Bone and Joint Initiative
2015
Patients with active rheumatoid arthritis (RA) have increased cardiovascular mortality, paradoxically associated reduced circulating lipid levels. The JAK inhibitor tofacitinib ameliorates systemic and joint inflammation in RA a concomitant increase serum lipids. We analysed the effect of on profile hyperlipidaemic rabbits chronic (CA) changes reverse cholesterol transport (RCT) during inflammation.
Abstract Inflammatory activity in rheumatoid arthritis may alter the regulation of muscle mass leading to a secondary sarcopenia, commonly termed cachexia (RC). We characterized alterations structure and various pro-inflammatory, catabolic regenerative markers an animal model RC. Antigen induced (AiA) was performed 20 male adult rabbits. AiA animals exhibited significantly less weight gain, markedly elevated serum C-reactive protein (CRP), lighter muscles with shorter cross-sectional...
The pathogenesis of osteoarthritis implicates a low-grade inflammation associated to the innate immune system activation. Toll like receptor (TLR) stimulation triggers release inflammatory mediators, which aggravate osteoarthritis. We studied preventive effect 6-shogaol, potential TLR4 inhibitor, on treatment experimental knee osteoarthritis.Osteoarthritis was induced in C57BL6 mice by surgical section medial meniscotibial ligament, received 6-shogaol for eight weeks. Cartilage damage,...
Sarcopenia is a frequent comorbidity of rheumatoid arthritis (RA). Clinical trials have shown that JAK inhibitors (JAKi) produce an asymptomatic increase in serum creatine kinase (CK) RA, suggesting impact on muscle. We evaluated the effect JAKi muscle remodeling experimental RA model. Antigen-induced (experimental e-RA) was performed 14 rabbits. Seven rabbits received tofacitinib (TOFA, orally 10 mg/kg/day). Animals were euthanized one day after last ovalbumin injection, and muscles...
Abstract Osteoarthritis (OA) is a multifactorial joint disease mainly affecting articular cartilage (AC) with relevant biomechanical component. During endochondral ossification growth plate (GP) chondrocytes arrange in columns. GPs do not ossify skeletally mature rodents. In neonatal mice, an altered loading induces GP chondrocyte disorganization. We aimed to study whether experimental OA involves disorganization adult mice and assess if it may have additional detrimental effects on AC...
Background Evaluation of quality care in oncology is key ensuring patients receive adequate treatment. American Society Clinical Oncology’s (ASCO) Quality Oncology Practice Initiative (QOPI) Certification Program (QCP) an international initiative that evaluates outpatient practices. Methods We retrospectively reviewed free-text electronic medical records from with breast cancer (BR), colorectal (CRC) or non-small cell lung (NSCLC). In a baseline measurement, high scores were obtained for the...
In order to gain insight into the early effects drawn by JAK inhibitors on intra-joint JAK/STAT-dependent signaling, we sought synovial activation of STATs and their end-products, along with modification tofacitinib (TOFA), at flare-up in antigen induced arthritis (AIA). New Zealand rabbits were randomly assigned four groups -healthy controls, AIA, TOFA-treated or controls-. AIA was 4 weekly intra-articular ovalbumin injections sensitized animals. TOFA (10 mg·kg- 1·day- 1) administered for...
Chondrocytes in osteoarthritic (OA) cartilage acquire a hypertrophic-like phenotype, where Hedgehog (Hh) signaling is pivotal. Hh overexpression causes OA-like lesions, whereas its downregulation prevents articular destruction mouse models. Mutations EVC and EVC2 genes disrupt signaling, are responsible for the Ellis-van Creveld syndrome skeletal dysplasia. Since protein (Evc) deletion expected to hamper target gene expression we hypothesized that it would also prevent OA progression...
388 Background: Multidisciplinary Tumor Boards are an essential component of patient management, as they integrate input from various healthcare professionals to make comprehensive decisions about care. Management patients with genitourinary (GU) tumors particularly relies on these multidisciplinary Boards. However, there no guidelines how groups should operate. Methods: A systematic literature review was conducted identify criteria useful evaluate quality in GU (GUTB); publication dates...
Background:The pathogenesis of osteoarthritis (OA) implicates a low-grade inflammation associated to the activation innate immune system. Toll like receptor (TLR) stimulation triggers release inflammatory mediators, which aggravate OA severity. The aim was study preventive effect 6-shogaol (6S), potential TLR4 inhibitor, on treatment experimental knee OA. Experimentalapproach:OA induced in C57BL6 mice by surgical section medial meniscotibial ligament, received 6S for eight weeks. Cartilage...
<h3>Background</h3> Osteoarthritis (OA) is a complex joint disease characterised by progressive lost of articular cartilage (AC), synovial inflammation and subchondral bone alterations. The latest theories OA pathogenesis implicate the interplay between mechanical damage chronic that has been associated to activation innate immune system, intricately involved in development this low-grade inflammation. During course OA, Toll like receptor (TLR) related release cytokines inflammatory...