A5025513759- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Rheumatoid Arthritis Research and Therapies
- Bone health and treatments
- Bone Metabolism and Diseases
- Cytokine Signaling Pathways and Interactions
- Bone health and osteoporosis research
- Proteoglycans and glycosaminoglycans research
- Estrogen and related hormone effects
- Bone and Joint Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal pain and rehabilitation
- Cell Adhesion Molecules Research
- Tendon Structure and Treatment
- Musculoskeletal synovial abnormalities and treatments
- NF-κB Signaling Pathways
- Chemokine receptors and signaling
- Medical and Biological Sciences
- Medicinal plant effects and applications
- TGF-β signaling in diseases
- Orthopedic Surgery and Rehabilitation
- Shoulder Injury and Treatment
- Connective tissue disorders research
- Knee injuries and reconstruction techniques
- Spine and Intervertebral Disc Pathology
International Potato Center
2023
Hospital Universitario Fundación Jiménez Díaz
2011-2020
Universidad Autónoma de Madrid
2012-2020
Peruvian University of Applied Sciences
2015
Zero to Three
2012
Thomas Jefferson University
2003-2010
Hospital Universitario de La Princesa
2010
Universidad de Granada
2010
Jefferson Institute
2008-2009
EsSALUD
2006
Osteoporosis (OP) increases cartilage damage in a combined rabbit model of OP and osteoarthritis (OA). Accordingly, we assessed whether microstructure impairment at subchondral bone aggravates this experimental model. was induced 20 female rabbits, by ovariectomy intramuscular injections methylprednisolone hemisuccinate for four weeks. Ten healthy animals were used as controls. At week 7, OA surgically left knees all rabbits. 22 weeks, after sacrifice, parameters micro-computed tomography,...
Objective To assess the efficacy and safety of combination therapy with chondroitin sulfate (CS) glucosamine (GS) compared to placebo in patients symptomatic knee osteoarthritis (OA). Methods A multicenter, randomized, double‐blind, placebo‐controlled study was performed 164 Kellgren/Lawrence grade 2 or 3 radiographic OA moderate‐to‐severe pain (mean ± SD global score 62.1 11.3 mm on a 100‐mm visual analog scale [VAS]). Patients were randomized receive either combined treatment CS (1,200 mg)...
Multinucleated giant cells have been noticed in diverse arthritic conditions since their first description rheumatoid synovium. However, role the pathogenesis of osteoarthritis (OA) or arthritis (RA) still remains broadly unknown. We aimed to study presence and characteristics multinucleated (MGC) both synovium subchondral bone tissues patients with OA RA. Knee synovial samples were from age-matched undergoing total joint replacement for RA, non-arthritic post mortem (PM) controls. was...
Experimental and clinical data support the hypothesis that both high low bone mineral density (BMD) conditions, including osteoporosis, may induce osteoarthritis. However, these conditions do not always predispose to osteoarthritis progression. Four settings could arise from this relationship, furthermore two phenotypes be identified whether early coexists with or BMD.
The receptor activator nuclear factor-kappaB ligand (RANKL) diffuses from articular cartilage to subchondral bone. However, the role of chondrocyte-synthesized RANKL in rheumatoid arthritis-associated juxta-articular bone loss has not yet been explored. This study aimed determine whether produced by chondrocytes induces osteoclastogenesis and associated with chronic arthritis.Chronic antigen-induced arthritis (AIA) was induced New Zealand (NZ) rabbits. Osteoarthritis (OA) control groups were...
Abstract Introduction Dental implant osseointegration can be impaired in medical conditions with low bone mass, such as glucocorticoid‐induced osteoporosis. Intermittent human parathyroid hormone ( PTH ) [1‐34] administration has shown relevant anabolic activity various animal models of Therefore, we studied the effects intermittent on response around titanium implants experimental osteoporosis induced by ovariectomy and glucocorticoid administration. Methods Titanium dental were placed...
Background Latin America is a heterogeneous region made up of different populations, cultures, latitudes, altitudes, and immigrants from areas ethnic groups. Objective The purpose this study to describe the clinical demographic profile patients with osteoarthritis (OA) evaluated by selected group rheumatologists in 13 American countries. Methods A descriptive, observational, cross-sectional was conducted countries symptomatic OA. Data were collected over 3-month period using an ad hoc...
Selective estrogen receptor β (ERβ) agonists have demonstrated relevant antiinflammatory effects in different animal models. This study aimed to compare the efficacy and safety of one these agonists, ERB-041, subjects with rheumatoid arthritis (RA).A total 291 patients active RA receiving stable doses methotrexate were randomized receive 5, 25, or 75 mg ERB-041 placebo for 12 weeks. The primary end point was American College Rheumatology 20% improvement criteria (ACR20) at Secondary points...