A5072985075- Inflammatory mediators and NSAID effects
- Chemokine receptors and signaling
- Mast cells and histamine
- Mesenchymal stem cell research
- Nutrition and Health in Aging
- Exercise and Physiological Responses
- Urticaria and Related Conditions
- Osteoarthritis Treatment and Mechanisms
- Gout, Hyperuricemia, Uric Acid
- Adenosine and Purinergic Signaling
- Bone and Joint Diseases
- Muscle Physiology and Disorders
- Inflammasome and immune disorders
Hospital Universitario Fundación Jiménez Díaz
2020-2025
Universidad Autónoma de Madrid
2020-2025
Osteoarthritis (OA) is a highly prevalent and disabling disease with an unmet therapeutic need. The characteristic cartilage loss alteration of other joint structures result from complex interaction multiple risk factors, mechanical overload consistently playing central role. This generates inflammatory response in the due to activation innate immune chondrocytes, which occurs through various cellular mechanisms. Moreover, factors associated obesity, being overweight, metabolic syndrome...
Sarcopenia is a frequent comorbidity of rheumatoid arthritis (RA). Clinical trials have shown that JAK inhibitors (JAKi) produce an asymptomatic increase in serum creatine kinase (CK) RA, suggesting impact on muscle. We evaluated the effect JAKi muscle remodeling experimental RA model. Antigen-induced (experimental e-RA) was performed 14 rabbits. Seven rabbits received tofacitinib (TOFA, orally 10 mg/kg/day). Animals were euthanized one day after last ovalbumin injection, and muscles...
Objective The specific effect of Adipose-Derived Mesenchymal Stem Cells (Ad-MSC) on acute joint inflammation, where the response mostly depends innate immunity activation, remains elusive. pathogenesis gouty arthritis, characterized by deposition monosodium urate (MSU) crystals in joints, associated to flares, has been NLRP3 inflammasome activation and subsequent amplification inflammatory response. Our aim was study human Ad-MSC administration clinical rabbits after MSU injection, molecular...