A5087829565- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Acute Kidney Injury Research
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Mechanical Circulatory Support Devices
- Cardiac, Anesthesia and Surgical Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- Cardiac Arrest and Resuscitation
- Respiratory viral infections research
- COVID-19 diagnosis using AI
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Diet and metabolism studies
- Ultrasound in Clinical Applications
- Antibiotic Resistance in Bacteria
- Diabetes and associated disorders
- Antibiotic Use and Resistance
- Tracheal and airway disorders
- Electrolyte and hormonal disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Pancreatitis Pathology and Treatment
- Lysosomal Storage Disorders Research
Institut d'Investigació Biomédica de Bellvitge
2015-2025
Bellvitge University Hospital
2015-2025
Mútua Terrassa
2025
Vall d'Hebron Institut de Recerca
2011-2022
Vall d'Hebron Hospital Universitari
2006-2022
Universitat de Barcelona
2017-2022
Ajuntament de L’Hospitalet
2021
Universitat Autònoma de Barcelona
1974-2011
Intensive Care Society
2007
Consorci Sanitari Garraf
2003
Introduction Loss-of-function TLR7 variants have been recently reported in a small number of males to underlie strong predisposition severe COVID-19. We aimed determine the presence these rare young men with Methods prospectively studied between 18 and 50 years-old without predisposing comorbidities that required at least high-flow nasal oxygen treat The coding region was sequenced assess potentially deleterious variants. Results missense were identified two out 14 patients (14.3%). Overall,...
It is important to predict which patients infected by SARS-CoV-2 are at higher risk of life-threatening COVID-19. Several studies suggest that neutralizing auto-antibodies (auto-Abs) against type I interferons (IFNs) predictive critical COVID-19 pneumonia.We aimed test for auto-Abs IFN and describe the main characteristics admitted intensive care depending on whether or not these present.Retrospective analysis all an unit (ICU) in whom samples were available, from March 2020 2021, Barcelona,...
Importance Cardiac surgery – associated acute kidney injury (CSA-AKI) remains a significant problem following cardiopulmonary bypass (CPB). Various strategies are proposed to attenuate CSA-AKI, including extracorporeal blood purification (EBP), but little is known about the effect of EBP through an acrylonitrile-sodium methallylsulfonate/polyethyleneimine membrane during CPB. Objective To determine whether use device in nonemergent cardiac population reduces CSA-AKI after Design, Setting,...
The use of lipid emulsions has been associated with changes in lung function and gas exchange which may be mediated by biologically active metabolites derived from arachidonic acid. type quantity the used could modulate this response, is eicosanoids. This study investigates omega-3 fatty acid-enriched ARDS patients their effects on eicosanoid values.Prospective, randomized, double-blind, parallel group carried out at Intensive Medicine Department Vall d'Hebron University Hospital...
Surgical site infection (SSI) remains a significant problem in the postoperative period that can negatively affect clinical outcomes. Microbiology findings are typically similar to other nosocomial infections, with differences dependent on microbiology selection due antibiotic pressure or resident flora. However, this is poorly understood critical care setting. We therefore aimed assess incidence, epidemiology and of SSI its association outcomes patients severe peritonitis intensive unit...
To analyse the usefulness of composite index tissue inhibitor metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) as urinary biomarkers for early prediction AKI in septic non-septic patients. This is a prospective, observational study including patients admitted to ICU from acute care departments hospital length stay <48 h. The main exclusion criteria were pre-existing eGFR <30 mL/min/1.73 m2 hospitalisation 2 months prior current admission....
Immunotherapy with immune checkpoint inhibitors (ICIs) have been reported to induce de novo or exacerbate pre-existing Myasthenia Gravis (MG). We present a single center case series of patients who developed an immune-related myasthenia gravis (irMG) related ICIs. performed retrospective chart review the electronic medical records between 1 September 2017 and 2022. report clinical features, presentation forms, diagnostic workflows, general management outcomes six received ICIs for different...
Abstract Introduction We investigated the effects on hemodynamics and gas exchange of a lipid emulsion enriched with omega-3 fatty acids in patients ARDS. Methods The design was prospective, randomized, double-blind, parallel group study our Intensive Medicine Department Vall d'Hebron University Hospital (Barcelona-Spain). studied 16 consecutive ARDS intolerance to enteral nutrition (14 men 2 women; mean age: 58 ± 13 years; APACHE II score: 17.8 2.3; Lung Injury Score: 3.1 0.5; baseline PaO...
Patients with coronavirus disease 2019 (COVID-19) can develop severe bilateral pneumonia leading to respiratory failure. We aimed study the potential role of lung ultrasound score (LUS) in subjects COVID-19.We conducted an observational, prospective pilot study, including consecutive admitted intermediate care unit due COVID-19 pneumonia. LUS is a 12-zone examination method for parenchyma assessment. was performed portable convex transducer, scores from 0 36 points. Clinical and demographic...
This study describes the incidence, evolution and prognosis of acute kidney injury (AKI) in critical COVID-19 during first pandemic wave. We performed a prospective, observational, multicenter confirmed patients admitted to 19 intensive care units (ICUs) Catalonia (Spain). Data regarding demographics, comorbidities, drug medical treatment, physiological laboratory results, AKI development, need for renal replacement therapy (RRT) clinical outcomes were collected. Descriptive statistics...
Objective: We study liver damage in forty-two patients with rheumatoid arthritis (RA) using light (LM) and electron microscopy (EM) assess histological changes after four years of treatment methotrexate (MTX). Patients methods: biopsies (LB) were taken before treatment. received weekly doses between 7.5 - 15 mg MTX. Results: Fourteen per cent the baseline LB presented mild perisinusoidal fibrosis (Roenigk IIIA) rest a lower Roenigk grade; EM identified an increase collagen fibers Disse...
We have evaluated the histological progression of liver disease in 29 untreated patients with chronic hepatitis C. All were positive to antibodies C virus by ELISA2 and RIBA2. Two biopsies carried out for each patient, an interval ranging between 12 126 months (mean 50.2±30.7). In all cases usual classification was applied activity index scoring system according Knodell et al. determined. Fifteen worsened (51.7%), showed no changes (41.4%) two improved (6.9%). Cirrhosis found five (18.5%)...
During early stages of COVID-19 pandemic, antimicrobials were commonly prescribed.To describe clinical, microbiological and antimicrobial use changes in bloodstream infections (BSI) ICU patients during the first wave pandemic compared to pre-COVID-19 era.Observational cohort study admitted Bellvitge University Hospital was conducted (March-June 2020) before 2019). Differences clinical characteristics, consumption incidence aetiology BSI measured.COVID-19 had significantly less comorbidities...