A5085146096- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Renal Transplantation Outcomes and Treatments
- Inflammatory Bowel Disease
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Microscopic Colitis
- Biosimilars and Bioanalytical Methods
- Patient Satisfaction in Healthcare
- COVID-19 Clinical Research Studies
- Antimicrobial Resistance in Staphylococcus
- Urinary Tract Infections Management
- Monoclonal and Polyclonal Antibodies Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Liver Disease and Transplantation
- Neutropenia and Cancer Infections
- Nosocomial Infections in ICU
- Rheumatoid Arthritis Research and Therapies
- Pharmacological Effects and Toxicity Studies
- Respiratory viral infections research
- Long-Term Effects of COVID-19
- Abdominal Surgery and Complications
Institut d'Investigació Biomédica de Bellvitge
2016-2025
Bellvitge University Hospital
2016-2025
Centro de Investigación Biomédica en Red
2022-2025
Universitat de Barcelona
2003-2025
Instituto de Salud Carlos III
2022-2024
Centro de Investigación en Red en Enfermedades Cardiovasculares
2022
American Pharmacists Association
2020
Pharmac
2019
Sir,Vancomycin is a commonly prescribed antibiotic for the treatment of severe Gram-positive infections and drug choice caused by MRSA. 1 Vancomycin cited as having potential to exacerbate myasthenia gravis, based upon reports neuromuscular blockade potentiation when
We aimed to determine whether daptomycin plus fosfomycin provides higher treatment success than alone for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and endocarditis.
Introduction Tacrolimus (Tac) has a narrow therapeutic window and shows large between-patient pharmacokinetic variability. As result, over-immunosuppression under-immunosuppression are frequently encountered in daily clinical practice. Unraveling the impact of genetic polymorphisms on Tac pharmacokinetics may help to refine therapy. In this study, associations single-nucleotide (SNPs) drug-metabolizing enzymes (CYP3A) with were investigated renal transplant recipients. Participants methods...
We assessed the antibiotic use in SARS-CoV-2-infected patients during four different waves of COVID-19 pandemic, as well its trends over period and associated risk factors. performed a cross-sectional retrospective analysis nested prospectively collected cohort hospitalized adult with at university hospital Spain. A total 2415 were included this study, among whom 1120 corresponded to first wave. The highest percentage receiving some sort treatment was higher wave (77.6%) than others;...
We assessed whether multiplex real-time PCR plus conventional microbiological testing is safe and more effective than alone for reducing antibiotic use in community-acquired pneumonia (CAP). In this randomised trial, we recruited adults hospitalised with CAP at four Spanish hospitals. Patients were randomly assigned (1:1) to undergo either non-invasive respiratory samples or alone. The primary endpoint was measured by days of therapy (DOT). Between February 20, 2020, April 24, 2023, 242...
Treatment of solid-organ transplant (SOT) patients with ganciclovir (GCV)-valganciclovir (VGCV) according to the manufacturer's recommendations may result in over- or underexposure. Bayesian prediction based on a population pharmacokinetics model optimize GCV-VGCV dosing, achieving area under curve (AUC) therapeutic target. We conducted two-arm, randomized, open-label, 40% superiority trial adult SOT receiving as prophylaxis treatment cytomegalovirus infection. Group A was treated...
Treatment failure occurs in about 25% of patients with methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. We assessed whether cloxacillin plus fosfomycin achieves better treatment success than alone hospitalized adults MSSA conducted a multicenter, open-label, phase III-IV superiority randomized clinical trial. randomly assigned (1:1) to receive 2 g intravenous every 4 h or 3 6 for the initial 7 days. The primary endpoint was at day 7, composite following criteria: patient...
Abstract Aim Prolonged antibiotic treatments contribute to increasing antimicrobial resistance. Current guidelines recommend 5–7 days of treatment in patients with surgical infection an adequate source control. Antibiotic stewardship aim optimize the use antibiotics, including their duration. The 7VINCut nationwide intervention aims reduce duration <7 patients. Methods Prospective cohort study conducted 37 hospitals 2019–2022. Patients admitted services >7 were analysed. teams...
A population pharmacokinetics analysis was performed after intravenous ganciclovir and oral valganciclovir in solid organ transplant patients with cytomegalovirus. Patients received at 5 mg/kg of body weight (5 days) then 900 mg (16 days), both twice daily dose adjustment for renal function. total 382 serum concentrations from days 15 were analyzed NONMEM VI. Renal function given by creatinine clearance (CL(CR)) the most influential covariate CL. The final pharmacokinetic parameters as...
Background: To evaluate the efficacy and safety of long-term use tedizolid in osteoarticular infections. Methods: Multicentric retrospective study (January 2017–March 2019) infection cases treated with tedizolid. Failure: clinical worsening despite antibiotic treatment or need suppressive treatment. Results: Cases (n = 51; 59% women, mean age 65 years) included osteoarthritis 27, 53%), prosthetic joint 17, 33.3%), diabetic foot infections 9, 18%); where, were orthopedic device-related. Most...
Background: Daptomycin-induced eosinophilic pneumonia (DEP) is a rare but severe adverse effect and the risk factors are unknown. The aim of this study was to determine for DEP. Methods: A retrospective cohort performed at Bone Joint Infection Unit Hospital Universitari Bellvitge (January 2014–December 2018). To identify DEP, cases were divided into two groups: those who developed DEP without Results: Among whole (n = 229) we identified 11 (4.8%) percentage almost doubled in subgroup...
ObjectivesThe effect of the use immunomodulatory drugs on risk developing hospital-acquired bloodstream infection (BSI) in patients with COVID-19 has not been specifically assessed. We aim to identify factors for, and outcomes of, BSI among hospitalized severe pneumonia.MethodsWe performed a severity matched case–control study (1:1 ratio) nested large multicentre prospective cohort adults COVID-19. Cases were identified from database. Controls for age, sex acute respiratory distress...
Guidelines recommend 5-7 days of antibiotic treatment in patients with surgical infection and adequate source control. This nationwide stewardship intervention aimed to reduce the duration treatments <7 days.Prospective cohort study evaluating receiving antibiotics ≥7 32 hospitals. Indication for treatment, quality control, type recommendations issued, adherence were analysed. Temporal trends percentages >7 evaluated using a linear regression model Pearson's correlation coefficients.A total...
Importance Ambient air pollution and antimicrobial resistance pose significant global public health challenges. It is not known whether ambient associated with increased consumption of antimicrobials. Objective To assess a short-term association exists between levels among the general population seeking primary care consultations for acute respiratory symptoms. Design, Setting, Participants This 2-stage cross-sectional ecological time series analysis study using data on daily was conducted...
Voriconazole, an antifungal agent, displays high intra- and inter-individual variability. The predictive pharmacokinetic (PK) index requires a minimum plasma concentration (Cmin) in patient serum of between 1-5.5 mg/L. It is common to encounter fungal infections patients undergoing extracorporeal membrane oxygenation (ECMO) support, data regarding voriconazole PK changes during ECMO are scarce. Our study compared PKs with without support retrospective cohort critically-ill patients. Fifteen...
A. Caldés, S. Gil-Vernet, Y. Armendariz, H. Colom, L. Pou, J. Niubó, Lladó, Torras, N. Manito, G. Rufí, J.M. Grinyó. Sequential treatment of cytomegalovirus infection or disease with a short course intravenous ganciclovir followed by oral valganciclovir: efficacy, safety, and pharmacokineticsTranspl Infect Dis 2010: 12: 204–212. All rights reserved Abstract: Oral (p.o.) (IV) (GCV) has been the first-line agent for prevention (CMV) in solid organ transplantation (SOT). The introduction p.o....
Aims Therapeutic drug monitoring of infliximab can guide clinical decisions in patients with loss response and those who benefit from a de‐intensification. The aim this study was to determine the impact therapeutic combined Bayesian forecasting methodology on real‐world dataset suffering inflammatory bowel disease. Methods We performed single‐centre prospective one‐group pre‐test/post‐test design 108 adult disease treated model‐based dosing maintenance treatment. recorded activity scores...
During early stages of COVID-19 pandemic, antimicrobials were commonly prescribed.To describe clinical, microbiological and antimicrobial use changes in bloodstream infections (BSI) ICU patients during the first wave pandemic compared to pre-COVID-19 era.Observational cohort study admitted Bellvitge University Hospital was conducted (March-June 2020) before 2019). Differences clinical characteristics, consumption incidence aetiology BSI measured.COVID-19 had significantly less comorbidities...