A5027392986- Renal Transplantation Outcomes and Treatments
- Inflammatory Bowel Disease
- Microscopic Colitis
- Immunodeficiency and Autoimmune Disorders
- Biosimilars and Bioanalytical Methods
- COVID-19 Clinical Research Studies
- Liver Diseases and Immunity
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- Long-Term Effects of COVID-19
- Organ Transplantation Techniques and Outcomes
- Immune responses and vaccinations
- Fatty Acid Research and Health
- Monoclonal and Polyclonal Antibodies Research
- Rheumatoid Arthritis Research and Therapies
- Multiple Sclerosis Research Studies
- Diabetes and associated disorders
- Neurological Complications and Syndromes
- Esophageal and GI Pathology
- Psoriasis: Treatment and Pathogenesis
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Heavy Metal Exposure and Toxicity
- Esophageal Cancer Research and Treatment
Bellvitge University Hospital
2016-2025
Institut d'Investigació Biomédica de Bellvitge
2011-2023
Universitat de Barcelona
2017-2023
Ajuntament de L’Hospitalet
2021
Weatherford College
2021
Departament de Salut
2017
Duran i Reynals Hospital
1992-2004
Hospital de l'Esperança
2002
Universitat Autònoma de Barcelona
1986-1987
Abstract Exploring new immunosuppressive strategies inducing donor-specific hyporesponsiveness is an important challenge in transplantation. For this purpose, a careful immune monitoring and graft histology assessment mandatory. Here, we report the results of pilot study conducted twenty renal transplant recipients, analyzing immunomodulatory effects protocol based on induction therapy with rabbit anti-thymocyte globulin low doses, sirolimus, mofetil mycophenolate. Evolution cellular humoral...
In renal transplantation, chronic allograft nephropathy is the leading cause of long-term graft losses, transplant glomerulopathy being its glomerular form. Differential diagnosis from recurrent or de novo membranoproliferative glomerulonephritis should be established. Whether hepatitis C virus associated with cryoglobulinemia and damage in recipients, as native kidneys, not known. We identified six virus-infected recipients proteinuria higher than 1.5 g/day, microhematuria,...
The percentage of lymphocytic subsets in the blood cases with neuralgic amyotrophy (NA), and proliferative response lymphocytes cultured different nerve extracts, obtained from normal subjects at postmortem, were examined 6 patients NA 18 age-matched controls shoulder pain not related to NA. Most (5/6) had decreased CD3 values increased CD4/CD8 ratios due a CD8 subset. Lymphocytes their blastogenic activity cultures extracts brachial plexus nerves its branches, but sacral nerves. Cultures...
SARS-CoV-2 vaccines' effectiveness is not yet clearly known in immunocompromised patients. This study aims to assess the humoral and cellular specific immune response vaccines predictors of poor patients with common variable immunodeficiency (CVID) phenotype treated B-cell depletion therapies (BCDT), as well safety these vaccines. From March September 2021, we performed a prospective all adult who would receive vaccination were previously diagnosed (i) CVID syndrome (CVID group; n=28) or...
Background Musicogenic reflex seizures (MRS) are a rare form of described in patients with temporal lobe epilepsy (TLE), mainly unknown etiology. Epilepsy antibodies against glutamic acid decarboxylase (GAD-ab) is autoimmune for which no specific semiology has been described. Aim the study To retrospectively review incidence MRS general epileptic population and series GAD-ab to describe its clinical paraclinical characteristics. Methods Patients recorded between January 2010 2016 Database...
The "rods and rings" (RR) antinuclear antibody (ANA) pattern is believed to be restricted hepatitis C virus (HCV) infection related the treatment. This a 4-year retrospective study of all patients with RR from 20 000 serum samples received at Hospital Universitari de Bellvitge for ANA testing. Two control groups HCV without pattern: ANA-positive (n = 74) negative 75) were included. Eighty-seven had pattern. Seventy-three infected (prevalence 15% in population). could not ribavirin treatment,...
The relevance of abnormalities in the distribution peripheral blood T lymphocyte subsets to clinical manifestations multiple sclerosis is not firmly established. A and immunological follow-up relapsing-remitting patients was performed order study relationship immune changes with course disease. Twenty were monitored monthly during a mean time nine months for (CD3, CD4, CD8, CD19), including immunoregulatory CD4CD29 (helper-inducer), CD4CD45RA (suppressor-inducer) activated helper cells...
Background and objective: The HLA‐DRB1*15 allele is consistently associated with multiple sclerosis (MS) susceptibility in most studied populations. This study investigated the association between HLA‐DRB1 alleles presence of oligoclonal immunoglobulin G bands (OCB) cerebrospinal fluid (CSF) a Spanish population MS. Methods: typing was performed 268 patients sporadic MS detection OCB CSF. allelic frequencies were compared OCB‐positive OCB‐negative patients, both groups also 1088 unrelated...
Aims Therapeutic drug monitoring of infliximab can guide clinical decisions in patients with loss response and those who benefit from a de‐intensification. The aim this study was to determine the impact therapeutic combined Bayesian forecasting methodology on real‐world dataset suffering inflammatory bowel disease. Methods We performed single‐centre prospective one‐group pre‐test/post‐test design 108 adult disease treated model‐based dosing maintenance treatment. recorded activity scores...
Introduction: Severe lung injury is triggered by both the SARS-CoV-2 infection and subsequent host-immune response in some COVID-19 patients. Methods: We conducted a randomized, single-center, open-label, phase II trial with aim to evaluate efficacy safety of methylprednisolone pulses tacrolimus plus standard care (SoC) vs. SoC alone, hospitalized patients severe COVID-19. The primary outcome was time clinical stability within 56 days after randomization. Results: From April 1 May 2, 2020,...
Abstract The cornification of keratinocytes on the surface skin and oral epithelia is associated with degradation nuclear DNA. endonuclease DNase1L2 exonuclease Trex2 are expressed specifically in cornifying keratinocytes. Deletion causes retention DNA tongue epithelium but not skin. Here we report that lack results accumulation fragments cytoplasm lingual co-deletion massive throughout cornified layers epithelium. By contrast, cornification-associated breakdown was compromised epidermis....
Background: Infliximab (IFX) trough levels vary markedly between patients with inflammatory bowel disease (IBD), which is important for clinical response. The aim of this study was to evaluate the performance previously developed population pharmacokinetic models in IBD dose individualization Crohn (CD) and ulcerative colitis our setting. Methods: authors collected 370 prospectively from 100 adult who were undergoing IFX treatment July 2013 August 2016. external evaluation included...
SUMMARY Clonal deletion or inactivation of donor-specific alloreactive cells are important mechanisms that believed to account for acquired immune tolerance in allograft recipients. Serial assessment precursor cytotoxic T lymphocyte frequencies (CTLpf) by limiting dilution analysis (LDA) provides information at the clonal level on changes alloimmune response graft We performed a longitudinal study 15 cadaveric kidney recipients before and every 3 months throughout first year after...
Summary The aim of this study was to assess the expression CD23 on peripheral blood B‐cells. and its in vitro modulation by recombinant human interferon‐γ (IFN‐γ) phytohaem‐agglutinin‐ (PHA) or interleukin‐4 (IL‐4)‐stimulaled cultures atopic patients with Dermatophagoides pteromyssinus hyprrsensitivity healthy non‐atopic subjects. Atopic asthma not receiving allergen‐specific immunotherapy ( n = 21) were studied further compared a group subjects under 21 ). They age‐(± 5 yr) sex‐matched....
Background and aims: Treating patients based on a treat-to-trough approach has been shown to be cost-effective strategy for inflammatory bowel disease (IBD) who have become unresponsive infliximab (IFX). However, the documented evidence this is limited, some controversy remains regarding use of routine proactive therapeutic drug monitoring (TDM). To support TDM IFX regimen optimization in IBD patients, more in-depth knowledge covariates that affect pharmacokinetic (PK) variability needed....