A5058615987- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Diabetes and associated disorders
- Tumors and Oncological Cases
- Parvovirus B19 Infection Studies
- Histiocytic Disorders and Treatments
- interferon and immune responses
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Immune responses and vaccinations
- Immune Cell Function and Interaction
- Viral Infections and Outbreaks Research
Bellvitge University Hospital
2021-2023
Institut d'Investigació Biomédica de Bellvitge
2021-2023
Universitat de Barcelona
2021
Introduction Loss-of-function TLR7 variants have been recently reported in a small number of males to underlie strong predisposition severe COVID-19. We aimed determine the presence these rare young men with Methods prospectively studied between 18 and 50 years-old without predisposing comorbidities that required at least high-flow nasal oxygen treat The coding region was sequenced assess potentially deleterious variants. Results missense were identified two out 14 patients (14.3%). Overall,...
It is important to predict which patients infected by SARS-CoV-2 are at higher risk of life-threatening COVID-19. Several studies suggest that neutralizing auto-antibodies (auto-Abs) against type I interferons (IFNs) predictive critical COVID-19 pneumonia.We aimed test for auto-Abs IFN and describe the main characteristics admitted intensive care depending on whether or not these present.Retrospective analysis all an unit (ICU) in whom samples were available, from March 2020 2021, Barcelona,...
Life-threatening “breakthrough” cases of critical COVID-19 are attributed to poor or waning antibody (Ab) response SARS-CoV-2 vaccines in individuals already at risk. Preexisting auto-Abs neutralizing type I IFNs underlie least 15% pneumonia unvaccinated individuals; their contribution hypoxemic breakthrough vaccinated people is unknown. We studied a cohort 48 (aged 20 86 years) who received two doses messenger RNA (mRNA) vaccine and developed infection with 2 weeks 4 months later. Ab levels...
SARS-CoV-2 vaccines' effectiveness is not yet clearly known in immunocompromised patients. This study aims to assess the humoral and cellular specific immune response vaccines predictors of poor patients with common variable immunodeficiency (CVID) phenotype treated B-cell depletion therapies (BCDT), as well safety these vaccines. From March September 2021, we performed a prospective all adult who would receive vaccination were previously diagnosed (i) CVID syndrome (CVID group; n=28) or...
Performance of the QuantiFERON-TB Gold Plus (QFT-Plus) assay could be affected by conditions immune dysregulation. Little is known about reliability QTF-Plus in COVID-19 patients. Our aim was to determine prevalence and factors related an indeterminate QFT-Plus test hospitalized patients, analyze its relationship with in-hospital mortality. A retrospective analysis all patients on whom a performed tertiary care public hospital during first epidemic wave Spain (March–April 2020). Out total 96...
Introduction: Severe lung injury is triggered by both the SARS-CoV-2 infection and subsequent host-immune response in some COVID-19 patients. Methods: We conducted a randomized, single-center, open-label, phase II trial with aim to evaluate efficacy safety of methylprednisolone pulses tacrolimus plus standard care (SoC) vs. SoC alone, hospitalized patients severe COVID-19. The primary outcome was time clinical stability within 56 days after randomization. Results: From April 1 May 2, 2020,...
ABSTRACT Advanced age, male sex and chronic comorbidities are associated with severe COVID-19. However, these general risk factors cannot explain why critical illness occurs in young apparently healthy individuals. In the past months, several publications have identified susceptibility loci genes using comprehensive GWAS studies or genome, exome candidate analysis. A recent study reported rare, loss-of-function TLR7 variants otherwise brother pairs from two families We aimed to prospectively...