A5013496217- interferon and immune responses
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
- Dermatology and Skin Diseases
- Inflammasome and immune disorders
- Psoriasis: Treatment and Pathogenesis
- Ion channel regulation and function
- DNA Repair Mechanisms
- Immune Response and Inflammation
- Ferroptosis and cancer prognosis
- RNA Interference and Gene Delivery
- Acne and Rosacea Treatments and Effects
- Cardiac electrophysiology and arrhythmias
- Synthesis and Biological Evaluation
- Genetic factors in colorectal cancer
- Essential Oils and Antimicrobial Activity
- Skin and Cellular Biology Research
- Cancer-related Molecular Pathways
- Wound Healing and Treatments
- CRISPR and Genetic Engineering
- Advancements in Transdermal Drug Delivery
- Dermatologic Treatments and Research
- Genomics, phytochemicals, and oxidative stress
- RNA regulation and disease
- Fibroblast Growth Factor Research
Universitat de Barcelona
2009-2024
The Francis Crick Institute
2020-2024
Trinity College Dublin
2018-2024
University College London
2024
Institut d'Investigació Biomédica de Bellvitge
2017-2024
Bellvitge University Hospital
2013-2023
Imperial College London
2020-2021
Departament de Salut
2017
Universidad Autónoma de Madrid
2014
University of the Basque Country
2014
Nanocarriers, and especially nanostructured lipid carriers (NLC), represent one of the most effective systems for topical drug administration. NLCs are biodegradable, biocompatible provide a prolonged release. The glutamate release inhibitor Riluzole (RLZ) is currently used amyotrophic lateral sclerosis (ALS), with anti-proliferative effects potentially beneficial diseases excessive cell turnover. However, RLZ possesses low water solubility high light-sensibility. We present here optimized...
To investigate how the CARD14E138A psoriasis-associated mutation induces skin inflammation, a knock-in mouse strain was generated that allows tamoxifen-induced expression of homologous Card14E138A from endogenous Card14 locus. Heterozygous rapidly induced acanthosis, immune cell infiltration and pro-inflammatory genes. Homozygous more extensive inflammation severe systemic disease involving myeloid cells in multiple organs, temperature reduction, weight loss organ failure. This phenotype...
Voltage-dependent K(+) (Kv) channels from the Kv7 family are expressed in blood vessels and contribute to cardiovascular physiology. Although channel blockers trigger muscle contractions, activators act as vasorelaxants. Kv7.1 Kv7.5 many vessels. is under intense investigation because fail modulate smooth reactivity. In this study, we analyzed whether may form functional heterotetrameric increasing diversity vascular muscles.Kv7.1 currents elicited arterial myocytes, oocyte, mammalian...
Kv, which play a role in the immune system, are remodeled during carcinogenesis. Leukocytes present limited Kv repertoire, with Kv1.3 and Kv1.5 as isoforms that involved neoplastic processes, such proliferation migration. In this study, we identified B-lymphocytes, characterized its migration, analyzed expression human non-Hodgkin lymphomas. DLBCL, F, MCL, ALCL, T, along control N specimens, were analyzed. found to be differentially; whereas did not correlate state of dedifferentiation or...
Murine inflammatory caspase-11 has an important role in intestinal epithelial inflammation and barrier function. Activation of the non-canonical inflammasome, mediated by caspase-11, serves as a regulatory pathway for production pro-inflammatory cytokines IL-1β IL-18, key pyroptotic cell death. We have previously demonstrated protective during dextran sulphate sodium (DSS)-induced colitis, however importance colorectal tumour development remains unclear. Here, we show that Casp11−/− mice are...
TREX2 is a proofreading 3'-5' exonuclease that can be involved in genome maintenance; however, its biological role remains undefined. To better understand the function and physiologic relevance of TREX2, we generated mice deficient by targeted disruption unique coding exon. The knockout are viable do not show relevant differences growth, survival, lymphocyte development, or spontaneous tumor incidence compared with their wild-type counterparts over period up to 2 years. Also, did observe...
Trex2 is a keratinocyte-specific 3'-deoxyribonuclease that participates in the maintenance of skin homeostasis after DNA damage. Here, we show this exonuclease strongly upregulated human psoriasis, hyperproliferative and inflammatory disease. Similarly, imiquimod (IMQ)- Il23-induced mouse psoriasis was associated with substantial upregulation Trex2, which recruited into fragmented chromatin keratinocytes were undergoing impaired proliferation, differentiation, cell death, indicating an...
// Joan Manils 1 , Diana Gómez Mercè Salla-Martret Heinz Fischer 2 Jason M. Fye 3 Elena Marzo Laura Marruecos Inma Serrano Rocío Salgado 4 Juan P. Rodrigo 5 Juana Garcia-Pedrero Anna Serafin 6 Xavier Cañas Carmen Benito 7 Agustí Toll Sònia-Vanina Forcales 8 Fred W. Perrino Leopold Eckhart Concepció Soler Departament de Patologia i Terapèutica Experimental, Facultat Medicina, Campus Bellvitge, Universitat Barcelona, L’Hospitalet...
Abstract The cornification of keratinocytes on the surface skin and oral epithelia is associated with degradation nuclear DNA. endonuclease DNase1L2 exonuclease Trex2 are expressed specifically in cornifying keratinocytes. Deletion causes retention DNA tongue epithelium but not skin. Here we report that lack results accumulation fragments cytoplasm lingual co-deletion massive throughout cornified layers epithelium. By contrast, cornification-associated breakdown was compromised epidermis....
Voltage-dependent K (+) (Kv) channels are tightly regulated during the immune system response. Leukocytes have a limited repertoire of Kv channels, whose physiological role is under intense investigation. A functional channel an oligomeric complex composed pore-forming and ancillary subunits. The KCNE gene family novel group modulatory elements in leukocytes. Here, we characterized expression KCNEs (1-5) leukocytes investigated their regulation leukocyte proliferation mode activation. Murine...
<title>Abstract</title> Aberrant caspase recruitment domain family member 14 (CARD14) signaling has been strongly associated with inflammatory skin conditions. CARD14 acts as a scaffold protein, ultimately activating the transcription factor NF-KB. Although primarily studied in context of inflammation, recent research suggested its potential implications tumorigenesis. In this study, we gathered TCGA tumor data to gauge involvement cancer, including genetic alterations, expression patterns,...
Rare mutations in CARD14 promote psoriasis by inducing CARD14-BCL10-MALT1 complexes that activate NF-κB and MAP kinases. Here, the downstream signalling mechanism of highly penetrant CARD14E138A alteration is described. In addition to BCL10 MALT1, associated with several proteins important innate immune signalling. Interactions M1-specific ubiquitin E3 ligase HOIP, K63-specific TRAF6 promoted ubiquitination were essential for kinase activation. contrast, binding A20 ABIN1, both genetically...
Abstract Microbes are fascinating molecular machines which can be equipped with synthetic genetic programs that allow them to produce therapeutic molecules targeted on demand upon disease sensing. Cutibacterium acnes engraftment capacity and living habitat close important pharmacological targets makes it an attractive chassis create skin therapeutics. Here, we report the engineering of this bacterium, most abundant commensal human skin, secrete molecule neutrophil gelatinase-associated...
Dose of Trp53, the main keeper genome stability, influences tumorigenesis; however, causes underlying and driving tumorigenesis over time by loss a single p53 allele are still poorly characterized. Here, we found that specifically impacted oxidative, DNA damage inflammatory status hematopoietic lineages. In particular, Trp53 in mice triggered oxidative stress peripheral blood granulocytes spleenocytes, whereas lack two alleles produced enhanced thymus cells, resulting higher incidence...
Supplementary Figure Legend, Tables 1-2 from Increased Susceptibility to Skin Carcinogenesis in TREX2 Knockout Mice
Supplementary Figure 1 from Increased Susceptibility to Skin Carcinogenesis in TREX2 Knockout Mice
Supplementary Figure 1 from Increased Susceptibility to Skin Carcinogenesis in TREX2 Knockout Mice
Supplementary Figure Legend, Tables 1-2 from Increased Susceptibility to Skin Carcinogenesis in TREX2 Knockout Mice
<div>Abstract<p>TREX2 is a proofreading 3′-5′ exonuclease that can be involved in genome maintenance; however, its biological role remains undefined. To better understand the function and physiologic relevance of TREX2, we generated mice deficient TREX2 by targeted disruption unique coding exon. The knockout are viable do not show relevant differences growth, survival, lymphocyte development, or spontaneous tumor incidence compared with their wild-type counterparts over period up...