A5028453491- IL-33, ST2, and ILC Pathways
- RNA Research and Splicing
- Immunotherapy and Immune Responses
- Ubiquitin and proteasome pathways
- T-cell and B-cell Immunology
- NF-κB Signaling Pathways
- PI3K/AKT/mTOR signaling in cancer
- Fibroblast Growth Factor Research
- Immune Cell Function and Interaction
- Gut microbiota and health
- Protein Tyrosine Phosphatases
- Agriculture and Biological Studies
- Chemical and Physical Studies
- Human Health and Disease
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Eosinophilic Esophagitis
- Immune cells in cancer
- Skin and Cellular Biology Research
- Dermatology and Skin Diseases
VIB-UGent Center for Inflammation Research
2023-2024
Ghent University
2023-2024
Czech Academy of Sciences, Institute of Molecular Genetics
2020-2023
Abstract The development of thymic regulatory T cells (Treg) is mediated by Aire-regulated self-antigen presentation on medullary epithelial (mTECs) and dendritic (DCs), but the cooperation between these still poorly understood. Here we show that signaling through Toll-like receptors (TLR) expressed mTECs regulates production specific chemokines other genes associated with post-Aire mTEC development. Using single-cell RNA-sequencing, identify a new CD14 + Sirpα population monocyte-derived...
Interleukin (IL)-17 protects epithelial barriers by inducing the secretion of antimicrobial peptides. However, effect IL-17 on Paneth cells (PCs), major producers peptides in small intestine, is unclear. Here, we show that targeted ablation receptor (IL-17R) PCs disrupts their functions and decreases frequency ileal PCs. These changes become more pronounced after colonization with segmented filamentous bacteria. Mice lack IL-17R an increased inflammatory transcriptional profile ileum along...
Differences in frequencies of blood cell subpopulations were reported to influence the course infections, atopic and autoimmune diseases, cancer. We have discovered a unique mouse strain B10.O20 containing extremely high frequency myeloid-derived cells (MDC) spleen. carries 3.6% genes O20 on C57BL/10 genetic background. It contains much higher CD11b + Gr1 spleen than both its parents. O20-derived segments chromosomes 1, 15, 17, 18. Their linkage with was tested F 2 hybrids between C57BL/10....
Rare mutations in CARD14 promote psoriasis by inducing CARD14-BCL10-MALT1 complexes that activate NF-κB and MAP kinases. Here, the downstream signalling mechanism of highly penetrant CARD14E138A alteration is described. In addition to BCL10 MALT1, associated with several proteins important innate immune signalling. Interactions M1-specific ubiquitin E3 ligase HOIP, K63-specific TRAF6 promoted ubiquitination were essential for kinase activation. contrast, binding A20 ABIN1, both genetically...