A5063119797- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Inflammatory Biomarkers in Disease Prognosis
- Nutrition and Health in Aging
- Pleural and Pulmonary Diseases
- Cancer Genomics and Diagnostics
- Frailty in Older Adults
- Cancer-related molecular mechanisms research
- Cancer Diagnosis and Treatment
- Dysphagia Assessment and Management
- Occupational and environmental lung diseases
- Cancer survivorship and care
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Sinusitis and nasal conditions
- Neutropenia and Cancer Infections
- Medication Adherence and Compliance
- Venous Thromboembolism Diagnosis and Management
- Neuroblastoma Research and Treatments
- Cancer Treatment and Pharmacology
Institut Català d'Oncologia
2019-2025
Institut Català d'Ornitologia
2023-2024
Duran i Reynals Hospital
2019-2023
Institut d'Investigació Biomédica de Bellvitge
2022-2023
Spanish Society of Hematology and Hemotherapy
2022
Hospital Universitario Insular de Gran Canaria
2016-2019
Abstract Purpose Immune Checkpoint Inhibitors (ICI) can be associated with thrombotic events, both venous and arterial (VTE/AT). However, there is a paucity of information regarding patients in routine clinical practice. Methods/patients Retrospective, multicenter study promoted by the Thrombosis Cancer Section Spanish Society Medical Oncology (SEOM). Patients melanoma lung cancer who initiated ICI between 01/01/2015 31/12/2019 were recruited. Minimum follow-up was 6 months (unless it not...
Immunotherapy with immune checkpoint inhibitors (ICIs) have been reported to induce de novo or exacerbate pre-existing Myasthenia Gravis (MG). We present a single center case series of patients who developed an immune-related myasthenia gravis (irMG) related ICIs. performed retrospective chart review the electronic medical records between 1 September 2017 and 2022. report clinical features, presentation forms, diagnostic workflows, general management outcomes six received ICIs for different...
•The TSO500 panel was useful to identify actionable driver alterations in patients with NSCLC.•Hybrid capture sequencing using had a very low failure rate clinical samples.•A high concordance observed between single-gene testing and NGS.•Large NGS panels provide additional genomic information which could have impact on therapeutic or prevention strategies. BackgroundTargeted next-generation (NGS) is recommended screen (GAs) non-small-cell lung cancer (NSCLC). We determined the feasibility...
10630 Background: Patients with early onset lung cancer might be more likely to carry pathogenic (or likely-pathogenic) germline variants (PGV) in genes associated predisposition. However, testing is not recommended this population. We designed study determine the prevalence of PGVs patients cancer. Methods: This prospective, multicenter cohort assessed PGV younger than 51 years diagnosed non-small cell (NSCLC) 3 sites at Catalan Institute Oncology between June 2018 May 2022. Genomic DNA was...
Lung adenocarcinoma (LUAD) is a molecularly heterogeneous disease. In addition to genomic alterations, cancer transcriptional profiling can be helpful tailor treatment and estimate each patient's outcome. Transcriptional activity levels of 50 molecular pathways were inferred in 4573 LUAD patients using Gene Set Variation Analysis (GSVA) method. Seven subtypes defined independently validated based on the combined behavior studied pathways: AD (adenocarcinoma subtype) 1-7. AD1, AD4, AD5...
<title>Abstract</title> <bold>Background</bold> Oropharyngeal squamous cell carcinoma (OPSCC) of human papillomavirus (HPV)-positive status is increasing relative to HPV-negative disease. Nutritional features OPSCC patients according HPV unclear. <bold>Subjects/Methods:</bold> Canadian and Spanish with were assessed for body mass index (BMI), weight loss grade (WLG), computed tomography-defined skeletal muscle (SMI). Chi-square, t-test, Mann-Whitney-U, Kruskal-Wallis tests conducted compare...
Objectives Anti-PD-(L)1 agents changed the landscape of recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) treatment. Previous studies showed improved response rates to salvage chemotherapy (SCT) after progression anti-PD-(L)1 agents. This study aims evaluate outcomes SCT identify predictors survival in patients with R/M HNSCC. Materials methods Retrospective cohort analysis 63 treated antiPD-(L1)-based therapy between January 2015 August 2022. The overall rate (ORR)...
6057 Background: Up to 24% of patients (pts) newly-diagnosed with LA-HNSCC are 70 years old (yo). NCCN guidelines recommend a geriatric assessment guide treatment decisions in this pts population. Comprehensive (CGA) older HNSCC was implemented at our institution 2018. We evaluated the impact CGA decision and outcome compare it control cohort no treated within same institution. Methods: Retrospective single-institution analysis two consecutively-treated cohorts elderly Catalan Institute...