A5060670657- Venous Thromboembolism Diagnosis and Management
- Central Venous Catheters and Hemodialysis
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Acute Myocardial Infarction Research
- Healthcare professionals’ stress and burnout
- Cell Adhesion Molecules Research
- COVID-19 and healthcare impacts
- Atrial Fibrillation Management and Outcomes
- Advances in Oncology and Radiotherapy
- Cardiac tumors and thrombi
- Neuroendocrine Tumor Research Advances
- Inflammatory Biomarkers in Disease Prognosis
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- COVID-19 Clinical Research Studies
- Lung Cancer Research Studies
- Economic and Financial Impacts of Cancer
- Colorectal and Anal Carcinomas
- Dialysis and Renal Disease Management
- Diagnosis and Treatment of Venous Diseases
- Diversity and Career in Medicine
- Pancreatic and Hepatic Oncology Research
- Protease and Inhibitor Mechanisms
- Esophageal and GI Pathology
Hospital General Universitario Morales Meseguer
2016-2025
Universidad de Murcia
2022-2024
Spanish Society of Hematology and Hemotherapy
2022-2024
Centro Regional de Hemodonación
2022
Abstract Purpose Immune Checkpoint Inhibitors (ICI) can be associated with thrombotic events, both venous and arterial (VTE/AT). However, there is a paucity of information regarding patients in routine clinical practice. Methods/patients Retrospective, multicenter study promoted by the Thrombosis Cancer Section Spanish Society Medical Oncology (SEOM). Patients melanoma lung cancer who initiated ICI between 01/01/2015 31/12/2019 were recruited. Minimum follow-up was 6 months (unless it not...
Treatment with nab-paclitaxel plus gemcitabine increases survival in patients metastatic pancreatic cancer. However, the assessment of treatment efficacy and safety non-selected a real-life setting may provide useful information to support decision-making processes routine practice.Retrospective, multicenter study including cancer, who started first-line between December 2013 June 2015 according clinical practice. In addition describing pattern, overall (OS) progression-free (PFS) were...
•Oncologists are susceptible to burnout. The COVID-19 pandemic has significantly impacted health care workers' mental health.•This study analyzes professional burnout and its determinants as well the impact of among young oncologists.•Ensuring specialized training preventing essential ensure quality medical oncology in future. BackgroundYoung oncologists at particular risk burnout, this could have a significant on their patients. coronavirus disease 2019 (COVID-19) forced rapid changes...
Thrombosis may be included in the profile of side effects associated with CDK4/6 inhibitors. Its significance might greater than reported randomized clinical trials. To investigate this, a retrospective, multicenter study was conducted. The primary objective to calculate incidence thrombosis Secondary objectives examining impact on survival and identifying predictor variables for development venous thromboembolism (VTE) or arterial (AT). A total 986 patients were recruited. VTE/AT inhibitor...
The objective of this study was to validate the PredictAI models for predicting major bleeding (MB) in patients with active cancer and venous thromboembolism (VTE) anticoagulant (ACO) therapy, within 6 months after primary VTE, using an independent cohort from TESEO database. This conducted external validation international, prospective registry July 2018 until October 2021. Data 40 Spanish Portuguese hospitals recruiting consecutive cases cancer-associated thrombosis under treatment without...
Both venous and arterial thrombotic events (VTE/AT) can be associated with Immune Checkpoint Inhibitors (ICI). However, there is a paucity of information apropos patients in routine clinical practice.
Advanced gastric cancer is one of the most thrombogenic neoplasms. However, genetic mechanisms underlying this complication remain obscure, and molecular histological heterogeneity neoplasm hinder identification thrombotic biomarkers. Therefore, our main objective was to identify genes related thrombosis regardless Lauren subtypes. Furthermore, in a secondary exploratory study, we seek discover thrombosis-associated that were specific each TCGA subtype. We designed nested case-control study...
Hepsin is a type II transmembrane serine protease whose deregulation promotes tumor invasion by proteolysis of the pericellular components. In colorectal cancer, implication hepsin unknown. Consequently, we aimed to study correlations between expression and different clinical-histopathological variables in 169 patients with localized cancer 118 metastases. Tissue microarrays were produced from samples at diagnosis primary tumors stained an anti-hepsin antibody. was correlated using...
e24123 Background: The risk factors for bleeding during anticoagulation in patients with cancer-associated thrombosis (CAT) remain largely unexplored. recently developed PredictAI model ( Muñoz Martín AJ et al. JCO 40, e18744-e18744(2022) was aimed to predict major (MB) anticoagulant-treated cancer within the first 6 months following venous thromboembolism (VTE) diagnosis. goal validate using an independent cohort of from TESEO international, observational, prospective registry. Methods:...
Both venous and arterial thrombotic events (VTE/AT) can be associated with immune checkpoint inhibitors (ICI). However, there is a paucity of information apropos patients in routine clinical practice.Retrospective, multicenter study promoted by the Thrombosis Cancer Section Spanish Society Medical Oncology (SEOM). Individuals kidney or bladder cancer who initiated ICI between 01/01/2015 12/31/2020 were recruited. Minimum follow-up was 6 months (except cases demise). The primary objective to...
Introduction There is currently no validated score capable of classifying cancer-associated pulmonary embolism (PE) in its full spectrum severity. This study has the EPIPHANY Index, a new tool to predict serious complications cancer patients with suspected or unsuspected PE. Method The PERSEO Study prospectively recruited individuals PE and active receiving antineoplastic therapy from 22 Spanish hospitals. estimation relative frequency θ based on Index categories was made using Bayesian...
Cyanacrylate is not free of complications and a more commonly used alternative in clinical practice are prostheses that have the disadvantage migrating these cases where there no stenosis; however, with their fixation using specific device, migrations greatly reduced. A good to cyanacrylate, especially orifices or large tracts which may appear, prostheses, also easier handle practice. Sometimes cancer patients upper gastrointestinal subsidiary surgical treatment, like tumor fistula,...
There is a lack of knowledge about the career paths and employment situation young medical oncologists. The aim our study was to evaluate current professional standing these professionals in Spain.The Spanish Society Medical Oncology + MIR section conducted national online survey May 2021 oncology consultants (< 6 years expertise) final year residents.A total 162 responses were eligible for analysis included participants from 16 autonomous communities; 64% women, 80% consultants, 20%...
ABSTRACT Background Hepsin is a type II transmembrane serine protease whose functions include degradation of the extracellular matrix and activation factor VII. In many tumors, hepsin dysregulation leads to tumor invasion by proteolysis pericellular components. Colorectal cancer with high thrombotic metastatic risk, but role unknown. Objectives To study correlations between expression in primary different clinical-histopathological variables patients localized colorectal cancer. Methods A...
Abstract Purpose The CoVID-TE model was developed with the aim of predicting venous thrombotic events (VTE) in cancer patients Sars-Cov-2 infection. Moreover, it capable hemorrhage and mortality 30 days following infection diagnosis. is pending validation. Methods/patients Multicenter retrospective study (10 centers). Adult active oncologic disease/ antineoplastic therapy hospitalized between March 1, 2020 1. 2022 were recruited. primary endpoint to association risk categories occurrence...
ABSTRACT Introduction There is currently no validated score capable of classifying cancer-associated pulmonary embolism (PE) in its full spectrum severity. This study has the EPIHANY Index, a new tool to predict serious complications cancer patients with suspected or unsuspected PE. Method The PERSEO Study prospectively recruited individuals PE and from 22 Spanish hospitals. estimation relative frequency θ based on EPIPHANY Index categories was made using Bayesian alternative for binomial...
11038 Background: A long-term planning of the oncologists’ career path is essential to approach continuous changes in oncology field given need further subspecialization after training period. Our aim evaluate current professional development young medical oncologists Spain and seek improvement strategies enhance their careers order guarantee commitment with research improve patient care outcomes. Methods: The SEOM +MIR Section launched a national online survey May 2021 aimed at consultants...