A5055250428- Diabetes Treatment and Management
- COVID-19 Clinical Research Studies
- Metabolism, Diabetes, and Cancer
- Lipoproteins and Cardiovascular Health
- Long-Term Effects of COVID-19
- Cancer Immunotherapy and Biomarkers
- Diabetes Management and Research
- Vitamin C and Antioxidants Research
- Hormonal Regulation and Hypertension
- Potassium and Related Disorders
- Heart Failure Treatment and Management
- Nutrition and Health in Aging
- Lung Cancer Treatments and Mutations
- Health Systems, Economic Evaluations, Quality of Life
- Dermatological and COVID-19 studies
- SARS-CoV-2 and COVID-19 Research
- Diabetes and associated disorders
- COVID-19 and healthcare impacts
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Pancreatic function and diabetes
- Cancer, Lipids, and Metabolism
- Pharmacology and Obesity Treatment
- Atherosclerosis and Cardiovascular Diseases
- Renin-Angiotensin System Studies
Hospital Universitario Río Hortega
2020-2025
Instituto de Investigación Biomédica de Salamanca
2014-2024
Universidad de Valladolid
2013-2024
Taos Orthopaedic Institute
2024
Instituto de Salud Carlos III
2024
Centro Nacional de Microbiologia
2024
Hospital Costa del Sol
2023
Administration for Children and Families
2023
Pontifical University of Salamanca
2019-2022
Complejo Hospitalario de Salamanca
2008-2021
Background: Although risk factors for atherosclerotic cardiovascular disease (ASCVD) in familial hypercholesterolemia (FH) have been described, models predicting incident ASCVD not reported. Our aim was to use the SAFEHEART registry (Spanish Familial Hypercholesterolemia Cohort Study) define key patients with FH. Methods: is a multicenter, nationwide, long-term prospective cohort study of molecularly defined population FH or without previous ASCVD. Analyses and build prediction equation were...
Heterozygous familial hypercholesterolemia (FH) is the most common premature atherosclerotic cardiovascular disease (ASCVD)-related monogenic disorder, and it associated with ischemic heart disease. There limited information whether FH increases risk of peripheral arterial cerebrovascular Our aim was to analyze ASCVD prevalence characteristics in different territories a large population, compare them an unaffected control population determine which factors are ASCVD.SAFEHEART (Spanish...
Mutations in the mismatch repair (MMR) system predict response to immune checkpoint inhibitors (ICIs) like colon or gastric cancer. However, MMR system's involvement non-small cell lung cancer (NSCLC) remains unknown. Addressing this issue will improve clinical guidelines case of mutations main genes (MLH1, MSH2, MSH6, and PMS2). This work retrospectively assessed role that these gene play survival ICIs NSCLC. Patients with NSCLC treated nivolumab as second-line treatment University Hospital...
Hypertension is a common hereditary syndrome with unclear pathogenesis. Chromogranin A (Chga), which catalyzes formation and cargo storage of regulated secretory granules in neuroendocrine cells, contributes to blood pressure homeostasis centrally peripherally. Elevated Chga occurs spontaneously hypertensive rat (SHR) adrenal glands plasma, but central expression unexplored. In this report, we measured SHR Wistar–Kyoto (control) peripheral nervous systems, found protein be decreased the...
•This study analyzes event rates of 2 high-potency statins in FH.•LDL-C goal attainment and risk were similar both groups.•LDL-C reduction was greater with rosuvastatin. Events groups.•Event rate 1.1/100 patient-years atorvastatin 1.2 BackgroundMaximal doses potent are the basement treatment familial hypercholesterolemia (FH). Little is known about use different statin regimens FH.ObjectivesThe objectives to describe changes low-density lipoprotein cholesterol (LDL-C) achievement (ATV)...
Since the first cases of COVID-19 were reported in Wuhan, nutritional status individuals infected with virus has not been included risk profiles prepared. However, status, along other factors, is decisive evolution patients infectious diseases. The considered an indicator health status. Furthermore, optimal transcends individual, and poor diet a population can be group factor. Evidence exists on influence that immune system susceptibility to disease.To evaluate older than 65 years who...
Background The impact of glucagon-like peptide-1 receptor agonists on patients with heart failure has not been fully described. Our main objective was to evaluate the safety and clinical glycemic efficacy once-weekly semaglutide in obese type 2 diabetes failure. Methods In this observational, retrospective, real-world study, we enrolled outpatients diabetes, obesity, who started were followed-up at 3, 6, 12 months. Results A total 136 included. From baseline months, there a significant...
The efficacy and safety of high versus medium doses glucocorticoids for the treatment patients with COVID-19 has shown mixed outcomes in controlled trials observational studies. We aimed to evaluate effectiveness methylprednisolone 250 mg bolus dexamethasone 6 severe COVID-19.A randomised, open-label, trial was conducted between February August 2021 at four hospitals Spain. suspended after first interim analysis since investigators considered that continuing would be futile. Patients were...
Antigen tests or polymerase chain reaction (PCR) amplification are currently COVID-19 diagnostic tools. However, developing complementary diagnosis tools is mandatory. Thus, we performed a plasma cytokine array in patients to identify novel biomarkers. A discovery–validation study two independent prospective cohorts was performed. The discovery cohort included 136 and non-COVID-19 recruited consecutively from 24 March 11 April 2020. Forty-five cytokines’ quantification by the MAGPIX system...
Objectives To investigate the use of once-weekly semaglutide in a real population people with type 2 diabetes mellitus (T2DM) three Spanish hospitals. Method An observational, retrospective and multicenter clinical study was designed that included 166 participants T2DM, distinguishing between group naïve to GLP-1RA (n=72) another switching from (n=94), all managed outpatient setting. The primary endpoint change HbA1c baseline end study. secondary endpoints changes body weight proportion...
Pneumonia is the main cause of hospital admission in COVID-19 patients. We aimed to perform an extensive characterization clinical, laboratory, and cytokine profiles order identify poor outcomes Methods: A prospective consecutive study involving 108 patients was conducted between March April 2020 at Hospital Clínico Universitario de Valladolid (Spain). Plasma samples from each patient were collected after emergency room admission. Forty-five serum cytokines measured duplicate, clinical data...
The presence of a procoagulant state, COVID-19-related coagulopathy, and an increased rate thrombotic events (TEs) is widely known about. However, descriptive studies are scarce. Here, we conducted large retrospective study including 2894 hospitalized COVID-19 patients followed up during the first 18 months pandemic to completely characterize any TE. Major TEs showed 3.45% incidence rate. were associated with intubation/90-day mortality risk [OR = 1.71, 95% CI (1.12–2.61), p < 0.013]....
Old age is one of the most important risk factors for severe COVID-19. Few studies have analyzed changes in clinical characteristics and prognosis COVID-19 among older adults before availability vaccines. This work analyzes differences features mortality unvaccinated very old during first successive waves Spain.
Chromogranin B (CHGB) is the major matrix protein in human catecholamine storage vesicles. CHGB genetic variation alters secretion and blood pressure. Here, effective Chgb under-expression was achieved by siRNA PC12 cells, resulting ~ 48% fewer secretory granules on electron microscopy, diminished capacity for uptake (by 79%), a 73% decline stores available nicotinic cholinergic-stimulated secretion. In vivo, loss of knockout mice resulted 35% chromaffin granule abundance 44% diameter,...