A5033081939- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Renal Transplantation Outcomes and Treatments
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Opioid Use Disorder Treatment
- Cannabis and Cannabinoid Research
- Colorectal Cancer Screening and Detection
- Pharmacogenetics and Drug Metabolism
- Colorectal Cancer Surgical Treatments
- Drug Transport and Resistance Mechanisms
- Gastric Cancer Management and Outcomes
- HIV/AIDS drug development and treatment
- Sleep and Wakefulness Research
- Diabetes Treatment and Management
- Forensic Toxicology and Drug Analysis
- SARS-CoV-2 and COVID-19 Research
- Medication Adherence and Compliance
- Pharmacological Effects and Toxicity Studies
- Pharmaceutical studies and practices
- Epilepsy research and treatment
- Poisoning and overdose treatments
Hospital Universitario de Canarias
2017-2024
Universidad Europea de Canarias
2022
Spanish Clinical Research Network
2021
Universidad de La Laguna
2020-2021
Hospital Universitario Insular de Gran Canaria
2021
Sociedad Española de Farmacología Clínica
2021
Hospital Universitario Río Hortega
2013
We aimed to determine the impact of tocilizumab use on severe COVID-19 (coronavirus disease 19) pneumonia mortality. performed a multicentre retrospective cohort study in 18 tertiary hospitals Spain from March April 2020. Consecutive patients admitted with treated were compared not tocilizumab, adjusting by inverse probability treatment weights (IPTW). Tocilizumab's effect receiving steroids during 48 h following inclusion was analysed. During period, 506 fulfilled criteria. Among them, 268...
Cannabinoid hyperemesis syndrome (CHS) is an uncommon but unique disorder defined by recurrent abdominal pain, intractable nausea, and emesis in patients who regularly smoke cannabis. The does not reliably respond to intravenous administration of the usual antiemetics improves with hot showers baths (hydrothermotherapy). Complete resolution CHS occurs only after cessation cannabis use.The authors review clinical features CHS, differences between cyclic vomiting syndrome, putative etiology,...
The efficacy and safety of high versus medium doses glucocorticoids for the treatment patients with COVID-19 has shown mixed outcomes in controlled trials observational studies. We aimed to evaluate effectiveness methylprednisolone 250 mg bolus dexamethasone 6 severe COVID-19.A randomised, open-label, trial was conducted between February August 2021 at four hospitals Spain. suspended after first interim analysis since investigators considered that continuing would be futile. Patients were...
Abstract Background: In transplant patients receiving de novo anticalcineurin-free sirolimus (SRL)-based immunosuppression, we determined the influence of cytochrome P450 3A5 (CYP3A5) and ATP-binding cassette, sub-family B (MDR/TAP), member ( ABCB1 ) genotypes on SRL blood levels medium-term relevant clinical outcomes, in order to improve effectiveness immunosuppression strategies when anti-mammalian target rapamycin (anti-mTOR) inhibitor is indicated for reasons. Methods: Forty-eight renal...
Objective: We tested the hypothesis that an enhanced bowel preparation strategy (EBS) improves colonic cleansing in patients at high risk for inadequate (HRI). Methods: This prospective randomized clinical trial included consecutive HRI referred outpatient colonoscopy between February and October 2019. was considered if scored >1.225 according to a previously validated bowel-cleansing predictive score. were (1:1) low-volume conventional (CBS) (1-day low residue diet (LRD) plus 2 L of...
Genetic variations impact drug response, driving the need for personalised medicine through pre-emptive pharmacogenetic testing. However, adoption of testing commonly prescribed drugs, such as statins, outside tertiary hospitals is limited due to a lack pharmacoeconomic evidence support widespread implementation by healthcare policy-makers. The Spanish Consortium Implementation Pharmacogenetics (iPHARMGx Consortium) addresses this developing clinical trial master protocol that will govern...
Background/Objectives: Post-transplant diabetes mellitus (PTDM) and prediabetes (PreDM) are common after renal transplantation increase the risk of cardiovascular events mortality. Compared to immediate-release tacrolimus (IR-Tac), LCPT formulation, with delayed absorption, offers higher bioavailability a smoother time-concentration curve, potentially reducing beta-cell stress. Methods: This randomized pilot trial compared de novo immunosuppression IR-Tac (twice daily) (once daily). At-risk...
Abstract Background Pulse glucocorticoid therapy is used in COVID-19 infection. We evaluated the effectiveness of methylprednisolone 250 mg/d for 3 days vs. dexamethasone 6 10 patients with severe but not critical pneumonia. Methods A multicentre, randomized, open-label, controlled trial was conducted between February 2021 and August at 4 hospitals Spain included 128 hospitalized adults confirmed pneumonia needing oxygen critically ill. Patients were randomly assigned a 1:1 ratio to receive...