A5111615281- Colorectal Cancer Screening and Detection
- Chemotherapy-induced cardiotoxicity and mitigation
- Adipose Tissue and Metabolism
- Redox biology and oxidative stress
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Surgical Treatments
- Autophagy in Disease and Therapy
- RNA Research and Splicing
- Nuclear Structure and Function
- Stoma care and complications
- Glutathione Transferases and Polymorphisms
- Communication and COVID-19 Impact
- Cancer-related cognitive impairment studies
- Sirtuins and Resveratrol in Medicine
- IgG4-Related and Inflammatory Diseases
- Sarcoma Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Energy and Environment Impacts
- Telemedicine and Telehealth Implementation
- Family Dynamics and Relationships
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
Hospital Universitario Puerta de Hierro Majadahonda
2024
Hospital Universitario de Canarias
2010-2022
Universidad de La Laguna
2015-2022
Center for Drug Evaluation and Research
2013-2020
United States Food and Drug Administration
2014-2020
Food and Drug Administration
2014
Baylor College of Medicine
2009-2012
In animal cells the nuclear lamina, which consists of lamins and lamin-associated proteins, serves several functions: it provides a structural scaffold for envelope tethers proteins heterochromatin to periphery. yeast, large heterochromatic domains including telomeres are also peripherally localized, but there is no evidence that yeast have or fibrous scaffold. Nonetheless, we found Lem2 Man1 fission Schizosaccharomyces pombe, evolutionarily distant relatives Lap2/Emerin/Man1 (LEM)...
Background and study aim Inadequate bowel cleansing negatively affects the efficiency of colonoscopy in routine clinical practice. The this was to design validate a predictive model for inadequate cleanliness. Patients methods built from 667 consecutive outpatients (development cohort) who were prospectively scheduled between June September 2014. validation cohort included 409 underwent October December Cleansing evaluated using Boston Bowel Preparation Scale (BBPS). preparation administered...
Objectives: Inadequate bowel cleansing is a major burden for endoscopy units. The aim of this study was to compare two intensive regimens in patients with previous colonoscopy inadequate preparation. Methods: Patients at index were randomized 4-L split-dose polyethylene-glycol (PEG) regimen vs. 2-L PEG plus ascorbic acid (PEG+Asc) regimen. All individuals underwent 3-day low-residue diet and received 10 mg bisacodyl, the day before colonoscopy. Cleansing considered be adequate if Boston...
The interplay between oxidative stress and autophagy is critical for determining the fate of cancer cells exposed to redox-active cytotoxic chemotherapeutic agents. Mitoquinone (MitoQ), a mitochondrially-targeted ubiquinone conjugate, selectively kills breast over healthy mammary epithelial cells. We reported previously that MitoQ, although derivative antioxidant ubiquinone, can generate excess ROS trigger Keap1-Nrf2 response in MDA-MB-231 cell line. Following MitoQ treatment, greater number...
Several front-line chemotherapeutics cause mitochondria-derived, oxidative stress-mediated cardiotoxicity. Iron chelators and other antioxidants have not completely succeeded in mitigating this effect. One hindrance to the development of cardioprotectants is lack physiologically-relevant animal models simultaneously study antitumor activity cardioprotection. Therefore, we optimized a syngeneic rat model examined mechanisms by which stress affects outcome. Immune-competent spontaneously...
Abstract Background The aim of this study was to assess whether a 3-day low-residue diet (LRD) improved bowel cleansing quality compared with 1-day LRD regimen. Methods Consecutive patients scheduled for outpatient colonoscopy were randomized the or groups. All received 2-L split-dose polyethylene glycol plus ascorbic acid. primary outcome as evaluated using Boston Bowel Preparation Scale (BBPS) (adequate ≥ 2 points per segment). Secondary outcomes adherence and level satisfaction LRD,...
<b>Background and study aims:</b> The European Panel on the Appropriateness of Gastrointestinal Endoscopy (EPAGE I) criteria were recently updated II), but no prospective studies have used these in clinical practice. aim current was to validate EPAGE II an open-access endoscopy unit. <b>Patients methods:</b> A observational conducted unit at a tertiary care referral center. Consecutive outpatients (n = 1004; mean age 58.9 ± 13.1 years; 45 % men) referred for diagnostic colonoscopy between...
The double lipid bilayer of the nuclear envelope (NE) remains intact during closed mitosis. In fission yeast Schizosaccharomyces pombe, intranuclear mitotic spindle has envelope-embedded pole bodies (SPB) at its ends. As elongates and nucleus divides symmetrically, volume constant but area rapidly increases by 26%. When Ran-GTPase function is compromised in S. division strikingly asymmetrical newly synthesized SPB preferentially associated with smaller nucleus, indicative a Ran-dependent...
Radiation-induced heart disease presents a significant challenge in the event of an accidental radiation exposure as well to cancer patients who receive acute doses irradiation part therapy. We utilized spontaneously hypertensive Wistar-Kyoto rat model, previously shown demonstrate drug-induced cardiomyopathy, evaluate and long-term effects sub-lethal total body gamma at two, four, fifty-two weeks. further examined irreversible oxidative protein carbonylation immediately following...
Radiation-induced heart disease presents a significant challenge in the event of an accidental radiation exposure as well to cancer patients who receive acute doses irradiation part therapy. We utilized Wistar-Kyoto and spontaneously hypertensive rat model, previously shown demonstrate drug-induced cardiomyopathy, evaluate long-term effects sub-lethal total body at two, four, fifty-two weeks. further examined irreversible oxidative protein carbonylation immediately following irradiation....
Objective: We tested the hypothesis that an enhanced bowel preparation strategy (EBS) improves colonic cleansing in patients at high risk for inadequate (HRI). Methods: This prospective randomized clinical trial included consecutive HRI referred outpatient colonoscopy between February and October 2019. was considered if scored &gt;1.225 according to a previously validated bowel-cleansing predictive score. were (1:1) low-volume conventional (CBS) (1-day low residue diet (LRD) plus 2 L of...
Abstract Background Primary aim: To assess the durability of ustekinumab treatment in patients with ulcerative colitis (UC). Secondary aims: short-term effectiveness, response, and tolerability clinical practice. Methods Retrospective, multicenter study including UC who had received 1st dose at least 16 weeks before inclusion. Patients were followed-up from to discontinuation or last visit. Only active disease [Partial Mayo Score (PMS)&gt;2] start considered effectiveness analysis....
Abstract Radiation-induced heart disease presents a significant challenge in the event of an accidental radiation exposure as well to cancer patients who receive acute doses irradiation part therapy. We utilized Wistar-Kyoto and spontaneously hypertensive rat model, previously shown demonstrate drug-induced cardiomyopathy, evaluate long-term effects sub-lethal total body at two, four, fifty-two weeks. further examined irreversible oxidative protein carbonylation immediately following...
Abstract Radiation-induced heart disease (RIHD) presents a significant challenge in the oncology setting. Patients who receive acute doses of irradiation to thoracic cavity for Hodgkin's Lymphoma and breast cancer are subject an elevated risk RIHD. The ability mitigate long-term cardiac effects radiation exposure these populations by modulating protein oxidation process autophagy has potential lead improved health outcomes. We utilized spontaneously hypertensive rat (SHR), which proven good...
Abstract Treatment of cancer with anthracyclines such as doxorubicin (Dox) causes dose-limiting cardiotoxicity, particularly in younger females and adult males. However, the exact reason for gender differences toxicity is unclear. Dox metabolites prompt generation excess reactive oxygen species (ROS) using an iron-mediated mechanism mitochondria. Cardiomyocytes, addition to having lower levels antioxidant enzymes also have higher concentrations mitochondria are therefore hypersensitive ROS....
Abstract Radiation-induced heart disease (RIHD) presents a significant challenge in the oncology setting. For instance, patients receiving acute doses of irradiation to thoracic cavity for Hodgkin's lymphoma or breast cancer are subject an elevated risk RIHD. Excessive oxidative stress, at least part, is responsible some tissue damage. The ability monitor and mitigate long-term cardiac effects radiation exposure these populations by modulating stress has potential lead improved health...
Abstract Radiation-induced heart disease represents a significant health risk in the event of an accidental radiation exposure as well to cancer patients who receive acute doses irradiation part therapy. We utilized Wistar-Kyoto and spontaneously hypertensive rat models, previously shown demonstrate drug-induced cardiomyopathy, evaluate long-term effects sub-lethal total body at two, four, fifty-two weeks. examined irreversible oxidative protein carbonylation immediately following...