A5089471971- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Osteoarthritis Treatment and Mechanisms
- Cancer-related gene regulation
- Bone health and treatments
- Orthopaedic implants and arthroplasty
- Wnt/β-catenin signaling in development and cancer
- Orthopedic Infections and Treatments
- Hip disorders and treatments
- Inflammatory mediators and NSAID effects
- Inflammatory Myopathies and Dermatomyositis
- Estrogen and related hormone effects
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- Endoplasmic Reticulum Stress and Disease
- Long-Term Effects of COVID-19
- Folate and B Vitamins Research
- Infectious Diseases and Tuberculosis
- interferon and immune responses
- Connective tissue disorders research
- Mesenchymal stem cell research
- Immunodeficiency and Autoimmune Disorders
- Hereditary Neurological Disorders
Marqués de Valdecilla University Hospital
2013-2025
Instituto de Investigación Marqués de Valdecilla
2013-2025
Universidad de Cantabria
2011-2022
LIDSEN Publishing Inc. (United States)
2021
University of Central Florida
2021
Fundación Marques de Valdecilla
2013
To determine whether a 6-day course of methylprednisolone (MP) improves outcome in patients with severe SARS-CoV‑2 (Corona Virus Disease 2019 [COVID-19]).
To determine genome-wide methylation profiles of bone from patients with hip osteoarthritis (OA) and those osteoporotic (OP) fractures.Trabecular pieces were obtained the central part femoral head 27 fractures 26 OA. DNA was isolated, explored Illumina arrays. RNA extracted, pooled, deep-sequenced to obtain whole transcriptome. Differentially methylated regions identified, connections between genes differentially by pathway text-mining analyses.After quality control, 23,367 CpG sites (13,463...
ABSTRACT Background We aimed to determine whether a 6-day course of intravenous methylprednisolone (MP) improves outcome in patients with SARS CoV-2 infection at risk developing Acute Respiratory Distress Syndrome (ARDS). Methods Multicentric, partially randomized, preference, open-label trial, including adults COVID-19 pneumonia, impaired gas exchange and biochemical evidence hyper-inflammation. Patients were assigned standard care (SOC), or SOC plus MP [40mg/12h 3 days, then 20mg/12h...
Genes explaining the susceptibility to osteoporosis have not been fully elucidated. Our objective was explore association of polymorphisms capturing common variations lipoprotein receptor-related protein (LRP) 5 and 6 genes, encoding two Wnt receptors, with femoral neck bone mineral density (BMD) osteoporotic fractures spine hip.Cross-sectional, case-control, replication genetic study.Thirty-nine tagging functional single nucleotide (SNPs) were analyzed in a group 1043 postmenopausal women...
Osteoporosis is a systemic skeletal disease characterised by reduced bone mineral density and increased susceptibility to fracture; these traits are highly heritable. Both common rare copy number variants (CNVs) potentially affect the function of genes may influence risk.To identify CNVs associated with osteoporotic fracture risk.We performed genome-wide CNV association study in 5178 individuals from prospective cohort Netherlands, including 809 cases, silico lookups de novo genotyping...
Abstract Objective Estrogen deprivation is a central mechanism in the development of osteoporosis with aging. Results from recent studies also suggest involvement estrogens pathophysiology osteoarthritis (OA). Aromatization androgenic precursors peripheral tissue main source postmenopausal women and men. However, importance aromatase expression bone subject controversy. This study was undertaken to determine samples patients hip fracture OA. Methods We studied 104 (n = 60) or primary OA 44)....
This study explores the genetic factors associated with atypical femoral fractures (AFF), rare prolonged anti-resorptive therapy. AFF are fragility that typically appear in subtrochanteric or diaphyseal regions of femur. While some cases resemble bone disorders, exact cause remains unclear. investigates 457 genes related to skeletal homeostasis 13 patients by exome sequencing, comparing results osteoporotic (n = 27) and Iberian samples from 1000 Genomes Project 107). Only one case carried a...
D-dimer was introduced in 2018 as an alternative biomarker for C-reactive protein (CRP) the diagnostic of prosthetic joint infection (PJI) criteria Musculoskeletal Infection Society. We assessed accuracy plasma diagnosis early, delayed, and late PJI according to Infectious Diseases Society America (IDSA) criteria, whether persistently high levels cases aseptic loosening (AL) may be predictive subsequent implant-related infection.A prospective study a consecutive series 187 revision...
Long noncoding RNAs (lncRNAs) contribute toward regulating gene expression and cell differentiation may be involved in the pathogenesis of several diseases. The objective this study was to determine patterns lncRNAs bone marrow mesenchymal stem cells (BMSCs) derived from patients with osteoporotic fractures their relevance osteogenic function. BMSCs were isolated femoral head hip (FRX) controls osteoarthritis (OA). We found 74 differentially expressed genes between FRX OA, which 33 lncRNA...
The administration of intravesical bacille Calmette-Guérin (BCG) in early stages bladder cancer is usually a safe therapy. Side-effects BCG immunotherapy can be both local and systemic nature. We report the first case Henoch-Schönlein purpura following BCG.
Cardiovascular disease (CVD) is the main cause of mortality among non-alcoholic fatty liver (NAFLD) patients. The aim was to explore level knowledge and clinical management cardiovascular risk (CVR) in NAFLD patients by Digestive Disease specialists.An anonymous web-based survey designed with 44 close-ended questions, divided into five sections, that were based on current guidelines CVD prevention. Between November 2019 January 2020, specialists from Spanish hospitals invited participate...
The aim of the study was to explore new markers in serum proteome associated with response antiosteoporosis drugs, namely teriparatide and denosumab. We obtained samples from 14 patients osteoporosis, both at baseline after 6 months treatment (n = 10) or denosumab 4). Samples were analyzed by nanoliquid chromatography coupled high-resolution mass spectrometry on a QTOF 5600 (SCIEX) apparatus. data Mascot against UniProtKB base then several quality-control filters applied for identification...
Human mesenchymal stem cells (MSCs) have the ability to differentiate into bone-forming osteoblasts. The aim of this study was elucidate if MSCs from patients with OP show a senescent phenotype and explore their in vivo.MSCs controls osteoarthritis (OA) were implanted subcutaneous tissue immunodeficient mice for histological analysis expression human genes by RT-PCR. senescence-associated (SASP) genes, as well p16, p21, galactosidase, studied cultures MSCs.In vivo bone formation evaluated...