A5011976953- Quantum Dots Synthesis And Properties
- Mesenchymal stem cell research
- Bone fractures and treatments
- Alzheimer's disease research and treatments
- Orthopedic Surgery and Rehabilitation
- Nanocluster Synthesis and Applications
- Carbon and Quantum Dots Applications
- Bone Metabolism and Diseases
- Reconstructive Surgery and Microvascular Techniques
- Digital Imaging in Medicine
- Neurological disorders and treatments
- Virus-based gene therapy research
- Orthopedic Infections and Treatments
- Cancer-related Molecular Pathways
- Heat Transfer Mechanisms
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Concrete and Cement Materials Research
- Plant-based Medicinal Research
- Cancer Research and Treatment
- Dental Radiography and Imaging
- RNA Research and Splicing
- Pain Mechanisms and Treatments
- Orthopaedic implants and arthroplasty
- Graphene research and applications
Universidad de Cantabria
2020-2022
Instituto de Investigación Marqués de Valdecilla
2020-2022
Cardiff University
2022
Marqués de Valdecilla University Hospital
2018-2021
University College London
2018
IMDEA Energy Institute
2018
Cancer Research UK
2011-2013
University of Buenos Aires
2006-2010
Consejo Nacional de Investigaciones Científicas y Técnicas
2009
Max Planck Institute for Biophysical Chemistry
2009
Amyloid β (Aβ) peptides, the primary constituents of senile plaques and a hallmark in Alzheimer's disease pathology, are generated through sequential cleavage amyloid precursor protein (APP) by β-site APP cleaving enzyme 1 (BACE1) γ-secretase. The early endosome is thought to represent major compartment for processing; however, mechanisms how BACE1 encounters largely unknown. In contrast internalization, which clathrin-dependent, we demonstrate that sorted endosomes via route controlled...
The striking differences between the clinical symptoms of tetanus and botulism have been ascribed to different fate parental neurotoxins once internalised in motor neurons. Tetanus toxin (TeNT) is known undergo transcytosis into inhibitory interneurons block release neurotransmitters spinal cord, causing a spastic paralysis. In contrast, botulinum (BoNTs) acetylcholine at neuromuscular junction, therefore inducing flaccid Whilst overt experimental evidence supports sorting TeNT axonal...
Quantum dots multifunctionalized with the amyloid protein α-synuclein act at nanomolar concentrations as very potent inducers of aggregation micromolar−millimolar bulk in vitro and cells. Fibrillation live cells, a process diagnostic Parkinson's disease, is accelerated up to 15-fold only ∼100 nanoparticles. The combination tetracysteine-tagged form specific for fluorogenic biarsenicals constitutes sensitive system studying pathological formation
Prep1 is known to interact in vivo with Pbx1 regulate development and organogenesis. We have identified a novel Prep1-interacting protein, p160 c-Myb binding protein (p160). compete for vitro, inhibits Prep1-dependent HoxB2 expression retinoic acid-treated NT2-D1 cells. The N-terminal physiologically truncated form of p160, p67, binds the sequence 63LFPLL67 HR1 domain Prep1. Mutation both L63 L66 impairs p160/p67 Pbx1. sequences required bind are mainly located residues 51 151....
Long noncoding RNAs (lncRNAs) contribute toward regulating gene expression and cell differentiation may be involved in the pathogenesis of several diseases. The objective this study was to determine patterns lncRNAs bone marrow mesenchymal stem cells (BMSCs) derived from patients with osteoporotic fractures their relevance osteogenic function. BMSCs were isolated femoral head hip (FRX) controls osteoarthritis (OA). We found 74 differentially expressed genes between FRX OA, which 33 lncRNA...
The purpose of this study was to analyze the regenerative capacity mesenchymal stem cells (MSCs) in treatment fractures. MSCs extracted from patients with osteoporotic hip fractures or osteoarthritis undergoing replacement surgeries were cultured and injected into mice femoral fracture. Two experimental models established, one for systemic administration (n = 29) another local 30). Fracture consolidation assessed by micro-CT histology. degree radiological corticalization better osteoporosis...
Abstract Primary afferent sensory neurons are incredibly long cells, often traversing distances of over 1 m in humans. Cutaneous stimuli transduced the periphery by specialised end organs or free nerve endings, which code stimulus into electrical action potentials that propagate towards central nervous system. Despite significant advances our knowledge neuron physiology and ion channel expression, many commonly used techniques fail to accurately model primary its entirety. In vitro...
Multifunctional nanoparticles, quantum dots (QDs) are being developed as uniquely sensitive tools for elucidating the (bio)chemical and (bio)physical molecular mechanisms underlying functional states, i.e. <i>molecular physiology</i>, of biological cells organisms. Here we present a group strategies examples (i) controlling spectroscopic properties QDs via Fluorescence Resonance Energy Transfer (FRET); (ii) determining emission spectra individual in population with an imaging spectrograph...
Human mesenchymal stem cells (MSCs) have the ability to differentiate into bone-forming osteoblasts. The aim of this study was elucidate if MSCs from patients with OP show a senescent phenotype and explore their in vivo.MSCs controls osteoarthritis (OA) were implanted subcutaneous tissue immunodeficient mice for histological analysis expression human genes by RT-PCR. senescence-associated (SASP) genes, as well p16, p21, galactosidase, studied cultures MSCs.In vivo bone formation evaluated...
Quantum dots (QDs) are unique probes due to their special properties (brightness, photostability, narrowband emission and broadband absorption), excellent bio(chemical)compatibility for imaging structures functions of <i>living</i> cells. When functionalized with ligands, they enable the recognition specific targets tracking dynamic processes extended periods time, detecting biomolecules a sensitivity extending single molecule level. Thus, devices based on such nanoparticles very powerful...
Enabling the direct infiltration of freeze-cast graphene structures with water-based ceramic suspensions, otherwise prevented by graphene’s intrinsic hydrophobic behaviour, can lead to production hierarchical graphene/ceramic composites in a cost-effective and replicable manner. In this study, addition triblock copolymer (PF127) formulation alumina slurries was used allow integration reduced oxide (rGO) scaffolds combining freeze-casting, wet chemistry processing Spark Plasma Sintering....
Objetivo: Las células madre mesenquimales (MSCs) son atractivas en la terapia regenerativa de patologías humanas. En los modelos murinos, que se trasplantan MSCs humanas, es muy importante poder distinguir el origen las identificadas órganos ratones. El objetivo este estudio fue determinar rendimiento del análisis basado PCR secuencias Alu humanas para detectar ADN humano después infusión médula ósea humana (hBMSCs) ratones inmunodeficientes.
Septic joint arthritis in the small joints of hand can be caused by penetrating trauma, ruptured ganglion cysts, or open dislocations, among others. The use external fixation for treatment this condition has been reported past as a means temporary distraction, secondary fusion procedures. In present article, authors describe surgical technique involving low-cost fixator primary arthrodesis infected distal interphalangeal hand. is fabricated with simple materials, threaded Kirshner wires,...
An even background and adequate light conditions are commonly considered key in the art of medical photography. Guidelines have been provided as to what use, (the sky blue has classically be best for hand surgery), which source many other factors affecting obtention a good quality image.[1] [2] [3] Recommendations on how set up photographic studio can also found indexed literature.[1] Mini-studios known lightboxes used commercial photography acquire pictures small- medium-sized products such...