A5021395949- RNA Research and Splicing
- DNA Repair Mechanisms
- Ubiquitin and proteasome pathways
- Genomics and Chromatin Dynamics
- Microtubule and mitosis dynamics
- RNA modifications and cancer
- Genetic Neurodegenerative Diseases
- Nerve injury and regeneration
- Endoplasmic Reticulum Stress and Disease
- Neurogenetic and Muscular Disorders Research
- Nuclear Structure and Function
- RNA regulation and disease
- Protein Degradation and Inhibitors
- Nanoplatforms for cancer theranostics
- Neurogenesis and neuroplasticity mechanisms
- Mitochondrial Function and Pathology
- NF-κB Signaling Pathways
- Breast Lesions and Carcinomas
- Immune cells in cancer
- Connective tissue disorders research
- Spondyloarthritis Studies and Treatments
- Retinoids in leukemia and cellular processes
- Adipose Tissue and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Ferroptosis and cancer prognosis
Hospital Universitari Germans Trias i Pujol
2024
Universidad de Cantabria
2011-2023
Instituto de Investigación Marqués de Valdecilla
2015-2023
Marqués de Valdecilla University Hospital
2004-2023
Centro de Investigación Biomédica en Red
2010-2018
Center for Rheumatology
2018
Biomedical Research Networking Center on Neurodegenerative Diseases
2010-2018
Universidad Cardenal Herrera CEU
2005
Instituto de Biomedicina y Biotecnología de Cantabria
2005
The Purkinje cell (PC) degeneration (pcd) phenotype results from mutation in nna1 gene and is associated with the death of PCs during postnatal life. Although pcd a model ataxic mouse, it shares clinical pathological characteristics inherited human spinocerebellar ataxias. PC mice provides useful neuronal system to study nuclear mechanisms involved DNA damage-dependent neurodegeneration, particularly contribution nucleoli Cajal bodies (CBs). Both structures are engaged housekeeping functions...
Nowadays, a number of promising strategies are being developed that aim at combining diagnostic and therapeutic capabilities into clinically effective formulations. Thus, the combination modified release provided by an organic encapsulation intrinsic physico-chemical properties from inorganic counterpart opens new perspectives in biomedical applications. Herein, biocompatible magnetic lipid nanocomposite vehicle was through efficient, green simple method to simultaneously incorporate...
Understanding the molecular mechanisms underlying biosynthetic interactions between particular nanomaterials with specific cells or proteins opens new alternatives in nanomedicine and nanotoxicology. Multiwalled carbon nanotubes (MWCNTs) have long been explored as drug delivery systems nanomedicines against cancer. There are high expectations for their use therapy diagnosis. These filaments can translocate inside cultured intermingle protein nanofilaments of cytoskeleton, interfering...
Abstract Defects in RNA splicing have been linked to human disorders, but remain poorly explored inflammatory bowel disease (IBD). Here, we report that expression of the chromatin and alternative regulator HP1γ is reduced ulcerative colitis (UC). Accordingly, gene inactivation mouse gut epithelium triggers IBD-like traits, including inflammation dysbiosis. In parallel, find its loss function broadly increases noise, favoring usage cryptic splice sites at numerous genes with functions...
There is growing evidence that defective DNA repair in neurons with accumulation of lesions and loss genome integrity underlies aging many neurodegenerative disorders. An important challenge to understand how can tolerate the persistent without triggering apoptotic pathway. Here we study impact unrepaired on chromatin architecture, kinetics damage response transcriptional activity rat sensory ganglion exposed 1-to-3 doses ionizing radiation (IR). In particular, have characterized structural,...
Neurons are highly vulnerable to DNA damage induced by genotoxic agents such as topoisomerase activity, oxidative stress, ionizing radiation (IR) and chemotherapeutic drugs. To avert the detrimental effects of lesions in genome stability, transcription apoptosis, neurons activate robust repair mechanisms. However, defective with accumulation unrepaired at basis brain ageing several neurodegenerative diseases. Understanding mechanisms which tolerate well defining genomic regions that more or...