A5074273419- Microtubule and mitosis dynamics
- Neurogenesis and neuroplasticity mechanisms
- Ubiquitin and proteasome pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Graphene and Nanomaterials Applications
- Carbon Nanotubes in Composites
- Cellular transport and secretion
- Nanoparticles: synthesis and applications
- Cerebrospinal fluid and hydrocephalus
- Barrier Structure and Function Studies
- Photoreceptor and optogenetics research
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Trace Elements in Health
- Nuclear Structure and Function
- Genetic Neurodegenerative Diseases
- Retinal Development and Disorders
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Cellular Mechanics and Interactions
- Erythrocyte Function and Pathophysiology
- Circadian rhythm and melatonin
- RNA regulation and disease
- Neuroscience of respiration and sleep
Universidad de Cantabria
2008-2021
Instituto de Investigación Marqués de Valdecilla
2014-2021
Santander Universities
2018
Oregon State University
2017
Mount Sinai Hospital
2015
Marqués de Valdecilla University Hospital
2010
University of Maryland, Baltimore
1990-1993
Neurological Surgery
1990-1992
Microtubules are hollow protein cylinders of 25 nm diameter which implicated in cytokinetics and proliferation all eukaryotic cells. Here we demonstrate vivo how multiwalled carbon nanotubes (MWCNTs) interact with microtubules human cancer cells (HeLa) blocking mitosis leading to cell death by apoptosis. Our data suggest that, inside the cells, MWCNTs display microtubule biomimetic properties, assisting enhancing noncentrosomal polymerization stabilization. These features might be useful for...
Zinc is a crucial element in biology that plays chief catalytic, structural and protein regulatory roles. Excess cytoplasmic zinc toxic to cells so there are cell-entry intracellular buffering mechanisms control availability. Tubulin actin two zinc-scavenging proteins essential components of the cellular cytoskeleton implicated cell division, migration architecture maintenance. Here we demonstrate how exposure different ZnO nanostructures, namely commercial nanoparticles custom-made...
The intranasal drug delivery route provides exciting expectations regarding the application of engineered nanomaterials as nano‐medicines or drug‐delivery vectors into brain. Among nanomaterials, multiwalled CNTs (MWCNTs) are some best candidates for brain cancer therapy since they well known to go across cellular barriers and display an intrinsic ability block cell proliferation triggering apoptosis. This study reveals that microglial cells, macrophages putative vehicles MWCNTs brain,...
Abstract Tubulin cofactors, initially identified as α‐, β‐tubulin folding proteins, are now believed to participate in the complex tubulin biogenesis and degradation routes, thus contribute microtubule functional diversity dynamics. However, a concrete role of cofactor B (TBCB) remains be elucidated because this protein is not required for biogenesis, it apparently essential life any organisms studied. In agreement with these data, here we show that TBCB localizes at transition zone growth...
Understanding the molecular mechanisms underlying biosynthetic interactions between particular nanomaterials with specific cells or proteins opens new alternatives in nanomedicine and nanotoxicology. Multiwalled carbon nanotubes (MWCNTs) have long been explored as drug delivery systems nanomedicines against cancer. There are high expectations for their use therapy diagnosis. These filaments can translocate inside cultured intermingle protein nanofilaments of cytoskeleton, interfering...
Inhibiting cancer cell migration and infiltration to other tissues makes the difference between life death. Multiwalled carbon nanotubes (MWCNTs) display intrinsic biomimetic properties with microtubules, severely interfering function of these protein filaments during proliferation, triggering Here it is shown MWCNTs disrupt centrosomal microtubule cytoskeletal organization potent antimigratory effects in different cells.
Abstract Little is known about the pathogenic mechanisms of IgA nephropathy, despite being most prevalent form glomerulonephritis in humans. We report this study that (New Zealand White (NZW) × C57BL/6)F1 mice predisposed to autoimmune diseases, expression a human bcl-2 (hbcl-2) transgene B cells promotes CD4-dependent lupus-like syndrome characterized by IgG and hypergammaglobulinemia, autoantibody production, development fatal glomerulonephritis. Histopathological analysis glomerular...
Microtubule-organizing centers recruit α- and β-tubulin polypeptides for microtubule nucleation. Tubulin synthesis is complex, requiring five specific cofactors, designated tubulin cofactors (TBCs) A–E, which contribute to various aspects of dynamics in vivo. Here, we show that cofactor D (TBCD) concentrated at the centrosome midbody, where it participates centriologenesis, spindle organization, cell abscission. TBCD exhibits a cell-cycle-specific pattern, localizing on daughter centriole G1...
Carbon nanotubes (CNTs) are likely to transform the therapeutic and diagnostic fields in biomedicine during coming years. However, fragmented vision of their side effects toxicity humans has proscribed use as nanomedicines. Most studies agree that biocompatibility depends on state aggregation/dispersion CNTs under physiological conditions, but conclusions confusing so far. This study designs an experimental setup investigate cytotoxic effect individualized multiwalled compared identical...
Mild oxidation treatments improve the<italic>in vitro</italic>and<italic>in vivo</italic>macrophage biodegradation of carbon nanotubes that trigger remarkable anti-tumoral effects in malignant melanoma solid tumors produced mice.
Abstract In electron microscopic studies of the supraoptic nuclei rat hypothalamus, structures identified as “coiled bodies” were found in magnocellular neurons. Although they could be seen elsewhere mature neurosecretory cells, coiled bodies commonly encountered developing neurons during postnatal period both sexes. They appeared distinctive nuclear inclusions consisting round‐to‐oval networks short electron‐dense strands embedded a less dense, fibrillar matrix, and lacking limiting...
Head and Neck Cancer (HNC) is the seventh most common cancer worldwide with a 5-year survival from diagnosis of 50%. Currently, HNC diagnosed by physical examination followed an histological biopsy, surgery being primary treatment. Here, we propose use targeted nanotechnology in support existing diagnostic therapeutic tools to prevent recurrences tumors poorly defined or surgically inaccessible margins. We have designed innocuous ligand-protein, based on receptor-binding domain Shiga toxin...