A5082000845- Spaceflight effects on biology
- Heart Rate Variability and Autonomic Control
- Non-Invasive Vital Sign Monitoring
- Cardiovascular and exercise physiology
- Cardiovascular and Diving-Related Complications
- Cardiovascular Health and Disease Prevention
- Thermoregulation and physiological responses
- Space Exploration and Technology
- Electromagnetic Fields and Biological Effects
- High Altitude and Hypoxia
- Anesthesia and Neurotoxicity Research
- Technology and Human Factors in Education and Health
- Medical and Biological Ozone Research
- Cardiovascular Syncope and Autonomic Disorders
- Human Health and Disease
- Cardiac Arrest and Resuscitation
- ECG Monitoring and Analysis
- Optical Imaging and Spectroscopy Techniques
- Climate Change and Health Impacts
- Hemodynamic Monitoring and Therapy
- Cardiovascular Health and Risk Factors
Institute of Biomedical Problems
2013-2024
Université Libre de Bruxelles
2015
Russian Academy of Sciences
2009-2013
State Research Center of the Russian Federation
2011
Abstract Head-down bed rest (HDBR) reproduces the cardiovascular effects of microgravity. We tested hypothesis that regular high-intensity physical exercise (JUMP) could prevent this deconditioning, which be detected using seismocardiography (SCG) and ballistocardiography (BCG). 23 healthy males were exposed to 60-day HDBR: 12 in a group (JUMP), others control (CTRL). SCG BCG measured during supine controlled breathing protocols. From linear rotational SCG/BCG signals, integral kinetic...
Recent advancements in the field of space medicine and technology have extended boundaries travel, presenting humankind with ability to explore undiscovered habitats. As humans embark on long range missions, adaptation mechanisms will be put test, challenging provision medical care space. To date, a vast amount knowledge has been accumulated through series experiments, both terrestrial simulation environments missions ISS. result, functional health state algorithm developed validated by...
The environmental conditions in space, particularly exposure to cosmic radiation, coupled with decreased mobility, altered glucose metabolism, and hemodynamic changes may promote cardiovascular disease Therefore, we assessed early vascular aging markers hemodynamics using a novel oscillometric blood pressure device.In eight cosmonauts (46.5 ± 5.3 yrs, 77.6 8.2 kg, 176 6.2 cm, 7 men/1woman), determined heart rate, peripheral pressure, central pulse wave velocity the supine position an...
The article presents the results of space experiment “Pneumocard”. investigation involved all 25 Russian members ISS crew. total 226 sessions were made including 130 aboard ISS, 50 prior to launch and 46 on return from mission. objective was study effects spaceflight factors autonomic regulation blood circulation, respiration cardiac contractility during long-duration purpose secure new research data that would clarify our present view adaptation mechanisms. Registered following signals:...
The transthoracic impedance cardiogram (ICG) and the acceleration ballistocardiogram (BCG) measured close to center of mass human body are generated by changes blood distribution. ICG is an integrated signal covering whole thorax spatial resolution poor. Comparison between both signals can be used elucidate source signal. We recorded ECG, ICG, BCG simultaneously in healthy subjects under resting microgravity conditions during parabolic flights. time interval R-peak ECG maximum (R-dZ/dtmax)...
The Sonocard experiment purpose was a noninvasive physiological signal recording from sleeping humans. In 2007-2012 the made by 22 Russian members of 17 missions to International space station. Of overall 302 experimental sessions 47 were performed pre, 215 in and 40 after flight. seismographic technique used pick up cosmonaut’s body microoscillations induced cardiac beats, respiration motor activity. flight model is midget device fitting into T-shirt pocket. Heart rate variability analysis...
In the article main principles of ballistocardiography are considered. Special attention is paid to registration spatial ballistocardiogramm. There exist two ballistocardiography: dynamic and seismic. event body displacements align an extent with shifting general center gravity. Ideal conditions for ballistocardiogram acquisition could be reached if rigidity internal relations had infinitely large value, while external was nearing zero. Then entire would depend only on forces imparted by...
<title>Abstract</title> The article analyzes how long-duration space missions effect on the heart rate variability parameters and invariable blood proteins. results are discussed taking into correlation between them. Seven Russian cosmonauts took part in research during their to International Space Station. Samples of dry drops were collected as experiment ''OMICs-SPK'', electrocardiogram samples "Cardiovector". It was established a linear relationship concentrations some proteins spectral...
<title>Abstract</title> Microgravity exposure induces cardiac deconditioning, primarily due to hypovolemia and inactivity. Animal models suggest microgravity may cause left ventricular (LV) papillary muscle atrophy, but this has not been studied in humans. This study used MRI assess LV mass morphology function nine male cosmonauts before 6 ± 2 days after long-duration spaceflight (247 90 days). Spaceflight did affect volumes ejection fraction increased heart rate (P < 0.001), output =...
It is common knowledge that during space missions (SMs) the cosmonauts are subjected to stresses. One of potential SMs problems disorders in bioelectrical parameters myocardium conductivity or arrhythmias. The paper analyzes results investigations into changes cardiac rhythm variability a group 5 (46 ± 4.5 yrs age) using ECG records containing episodes atrial and/or ventricular Mean mission duration each cosmonaut was about six months as standard. Analysis experimental data on occurrence may...
Ballistocardiography is recognized as a reliable method for non-invasive assessment of cardiovascular functions. In this work, wavelet approach was used on the y-axis ballistocardiogram (BCG) to evaluate respiratory sinus arrhythmia (RSA) phenomenon using new parameter: amplitude modulation induced by respiration (BAMR). Eamax, local maximum energy BCGy, quantified each cardiac cycle. Then time series Eamax created and analyzed continuous transform provide BAMR values. The ECG compute RSA...
The proposal is a complex experiment that had design – double-blind randomized placebo-controlled study. An effective measurement of the parameters human body was examined on 8 apparently healthy subjects during an exposure hours in altered magnetic conditions. results did not reveal significant risks for functional state with decrease multiplicity about 1000 times.
The study presents the results of evaluating changes in concentrations blood plasma proteins associated with heart rate variability (HRV) cosmonauts who have completed space missions lasting about 6months. 125 were quantified biological samples cosmonauts’ plasma. subgroups physiological processes HRV autonomic regulation identified using bioinformatic resources (Immunoglobulin heavy constant mu, Complement C1q subcomponent subunit C, Plasma serine protease inhibitor, Protein-72kDa type IV...
The article covers the studies of vascular wall functioning in cosmonauts using data pulse wave velocity as a biomarker early aging. investigations were performed with use device Mobilograph twice before launch, every 30 days 6-month ISS missions and on 4 8 recovery. Pulse has never exceeded threshold values suggesting that participation low-Earth orbital does not put at risk cardiac health threatening pathologies. Yet, conclusion can be premature given limited potentialities method hardware...