A5081737102- Research on Leishmaniasis Studies
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Trypanosoma species research and implications
- Immunotherapy and Immune Responses
- Toxin Mechanisms and Immunotoxins
- Parasites and Host Interactions
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immune responses and vaccinations
- Bone Metabolism and Diseases
- Immune cells in cancer
- Bone health and osteoporosis research
- Synthesis and Biological Evaluation
- Adipokines, Inflammation, and Metabolic Diseases
- vaccines and immunoinformatics approaches
- RNA Interference and Gene Delivery
- interferon and immune responses
- Viral Infections and Outbreaks Research
- Nuclear Structure and Function
- Food Allergy and Anaphylaxis Research
- Ubiquitin and proteasome pathways
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
Inmunotek (Spain)
2024-2025
Universidad Complutense de Madrid
2018-2025
Spanish National Centre for Cardiovascular Research
2012-2023
Research Institute Hospital 12 de Octubre
2018-2022
Universidad Autónoma de Madrid
2003-2017
Centro de Biología Molecular Severo Ochoa
2003-2017
Instituto de Salud Carlos III
2008-2013
Centro Nacional de Microbiologia
2008-2013
Global Viral
2013
Consejo Superior de Investigaciones Científicas
2006-2011
Interaction of T cell with antigen-bearing dendritic cells (DC) results in activation, but whether this interaction has physiological consequences on DC function is largely unexplored. Here we show that when DCs contact cells, initiate anti-pathogenic programs. Signals are transmitted from the to DC, through extracellular vesicles (EV) contain genomic and mitochondrial DNA, induce antiviral responses via cGAS/STING cytosolic DNA-sensing pathway expression IRF3-dependent interferon regulated...
The goal of successful anti-tumoural immunity is the development long-term protective to prevent relapse. Infiltration tumours with CD8+ T cells a resident memory (Trm) phenotype correlates improved survival. However, interplay circulating and Trm remains poorly explored in tumour immunity. Using different vaccination strategies that fine-tune generation or cells, here we show that, while both subsets are sufficient for anti-tumour immunity, presence improves efficacy. Transferred central...
In order to prime T cells, DCs integrate signals emanating directly from pathogens and their noxious action on the host. DNGR-1 (CLEC9A) is a DC-restricted receptor that detects dead cells. Therefore, we investigated possibility affects immunity cytopathic viruses. was essential for cross-presentation of dying vaccinia virus–infected (VACV-infected) cells CD8+ in vitro. Following injection VACV or VACV-infected into mice, detected ligand infected mediated cross-priming anti-VACV Loss...
The role of different DC subsets in priming and maintenance immunity against Leishmania major (L. major) infection is debated. transcription factor basic leucine zipper factor, ATF-like 3 (Batf3) essential for the development mouse CD103(+) DCs some functions CD8α(+) DCs. We found that were significantly reduced dermis Batf3-deficient C57BL/6 mice. Batf3(-/-) mice developed exacerbated unresolved cutaneous pathology following a low dose intradermal L. ear pinnae. Parasite load was increased...
Toll-like receptors (TLRs) engage networks of transcriptional regulators to induce genes essential for antimicrobial immunity. We report that NFAT5, previously characterized as an osmostress responsive factor, regulates the expression multiple TLR-induced in macrophages independently osmotic stress. NFAT5 was induction key gene Nos2 (inducible nitric oxide synthase [iNOS]) response low and high doses TLR agonists but is required Tnf Il6 mainly under mild stimulatory conditions, indicating...
CD8+ T cells mediate antigen-specific immune responses that can induce rejection of solid tumors. In this process, dendritic (DCs) are thought to take up tumor antigens, which processed into peptides and loaded onto MHC-I molecules, a process called "cross-presentation." Neither the actual contribution cross-presentation antitumor nor intracellular pathways involved in vivo clearly established because lack experimental tools manipulate process. To develop such tools, we generated mice...
Impairment of the intestinal barrier allows systemic translocation commensal bacteria, inducing a proinflammatory state in host. Here, we investigated innate immune responses following increased gut permeability upon administration dextran sulfate sodium (DSS) mice. We found that Enterococcus faecalis translocated to bone marrow DSS treatment and induced trained immunity (TI) hallmarks bone-marrow-derived mouse macrophages human monocytes. or heat-killed E. reprogrammed progenitors (BMPs),...
It has been reported that the level of protection provided by vaccines against murine visceral leishmaniasis (VL) is low and progress in research on VL may be due to lack appropriate models study protective immunity. We have analysed immunohistological features occurring BALB/c mice after intravenous administration 10(3), 10(5) 10(6) parasites Leishmania infantum. Our results show all cases parasite leads establishment infection development quantifiable which are dependent inoculum size....
Background Conventional type 1 dendritic cells (cDC1s) are central to antitumor immunity and their presence in the tumor microenvironment associates with improved outcomes patients cancer. DNGR-1 (CLEC9A) is a dead cell-sensing receptor highly restricted cDC1s. has been involved both cross-presentation of cell-associated antigens processes disease tolerance, but its role not clarified yet. Methods B16 MC38 cell lines were inoculated subcutaneously into wild-type (WT) DNGR-1-deficient mice....
Abstract Conventional dendritic cells (cDCs) scan and integrate environmental cues in almost every tissue, including exogenous metabolic signals. While cDCs are critical maintaining immune balance, their role preserving energy homeostasis is unclear. Here, we showed that Batf3-deficient mice lacking conventional type 1 DCs (cDC1s) had increased body weight adiposity during aging. This led to impaired expenditure glucose tolerance, insulin resistance, dyslipidemia, liver steatosis. cDC1...
Bone destruction is a hallmark of chronic inflammation, and bone-resorbing osteoclasts arising under such condition differ from steady-state ones. However, osteoclast diversity remains poorly explored. Here, we combined transcriptomic profiling, differentiation assays in vivo analysis mouse to decipher specific traits for inflammatory osteoclasts. We identified validated the pattern-recognition receptors (PRR) Tlr2, Dectin-1, Mincle, all involved yeast recognition as major regulators showed...
Allergens from pollen, mites, and moulds often sensitize patients simultaneously, posing challenges for developing stable effective combination vaccines. Alternaria alternata, a major source of indoor outdoor allergens, is strongly linked to asthma development contains proteolytic enzymes that can degrade other potentially reducing vaccine efficacy. This study aimed evaluate the safety, efficacy, stability polymerized A. alternata extracts (allergoids) compared native their compatibility...
Allergens from pollen, mites, and moulds often sensitise patients simultaneously, posing challenges for developing stable effective combination vaccines. Alternaria alternata, a major source of indoor outdoor allergens, is strongly linked to asthma development contains proteolytic enzymes that can degrade other potentially reducing vaccine efficacy. This study aimed evaluate the safety, efficacy, stability polymerised A. alternata extracts (allergoids) compared native their compatibility...