A5077929748- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- Polyamine Metabolism and Applications
- Biochemical and Molecular Research
- Synthesis and biological activity
- Insect and Pesticide Research
- Parasites and Host Interactions
- Pharmacological Effects and Assays
- Synthesis and bioactivity of alkaloids
- Bioactive Compounds and Antitumor Agents
- Pesticide Exposure and Toxicity
- Toxin Mechanisms and Immunotoxins
- Environmental Toxicology and Ecotoxicology
- Synthesis and Biological Activity
- Pesticide Residue Analysis and Safety
- Chemical synthesis and pharmacological studies
- RNA Interference and Gene Delivery
- Cardiovascular and exercise physiology
- Neuropeptides and Animal Physiology
- Parasitic Infections and Diagnostics
- Hormonal and reproductive studies
- Insect Pest Control Strategies
- Multicomponent Synthesis of Heterocycles
Universidad de León
2015-2024
Universidad de León
1994-2019
Freie Universität Berlin
2016
Université Laval
2013
Washington University in St. Louis
2009
Consejo Superior de Investigaciones Científicas
1996
Abstract Background Although the genome sequence of protozoan parasite Leishmania major was determined several years ago, knowledge its transcriptome incomplete, both regarding real number genes and their primary structure. Results Here, we describe first comprehensive analysis a from genus . Using high-throughput RNA sequencing (RNA-seq), total 10285 transcripts were identified, which 1884 considered novel, as they did not match previously annotated genes. In addition, our data indicate...
Background Visceral leishmaniasis (VL) is hypoendemic in the Mediterranean region, where it caused by protozoan Leishmania infantum. An effective vaccine for humans not yet available and severe side-effects of drugs clinical use, linked to parenteral administration route most them, are significant concerns current leishmanicidal medicines. New desperately needed treat VL phenotype-based High Throughput Screenings (HTS) appear be suitable achieve this goal coming years. Methodology/Principal...
Visceral leishmaniasis is a neglected vector-borne tropical disease caused by Leishmania donovani and infantum that endemic not only in East African countries, but also Asia, regions of South America the Mediterranean Basin. For pharmacological control this disease, there limited number old and, general, poorly adherent drugs, with multitude adverse effects low oral bioavailability, which favor emergence resistant pathogens. Pentavalent antimonials are first-line due to their misuse, strains...
The balance between the products of L-arginine metabolism in macrophages regulates outcome Leishmania major infection. can be oxidized by host inducible NO synthase to produce NO, which contributes parasite killing. In contrast, hydrolysis arginase blocks generation and provides polyamines, support proliferation. Additionally, encode their own has considerable potential modulate infectivity disease pathogenesis. this study, we compared impact on cellular immune response vitro vivo wild-type...
Background Leishmania major cutaneous leishmaniasis is an infectious zoonotic disease. It produced by a digenetic parasite, which resides in the phagolysosomal compartment of different mammalian macrophage populations. There urgent need to develop new therapies (drugs) against this neglected disease that hits developing countries. The main goal work establish easier and cheaper tool choice for real-time monitoring establishment progression pathology either BALB/c mice or vitro assays. To...
Visceral leishmaniasis is an emerging neglected tropical disease (NTD) caused by the protozoan Leishmania infantum in countries bordering Mediterranean Basin. Currently there no effective vaccine against this disease, and therapeutic approach based on toxic derivatives of Sb(V). Therefore, discovery new targets development drugs designed to inhibit them comprise extremely important fighting disease. DNA topoisomerases (Top) have been identified as promising for therapy leishmaniasis. These...
Drug discovery programs sponsored by public or private initiatives pursue the same ambitious goal: a crushing defeat of major Neglected Tropical Diseases (NTDs) during this decade. Both target-based and target-free screenings have pros cons when it comes to finding potential small-molecule leads among chemical libraries consisting myriads compounds. Within strategy, crystals pathogen recombinant-proteins are being used obtain three-dimensional (3D) structures in silico for structure-based...
Abstract Leishmaniasis is a group of zoonotic diseases caused by trypanosomatid parasite mostly in impoverished populations low-income countries. In their different forms, leishmaniasis prevalent more than 98 countries all over the world and approximately 360-million people are at risk. Since no vaccine currently available to prevent any form disease, control strategy mainly relies on early case detection followed adequate pharmacological treatment that may improve prognosis can reduce...