A5032498150- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Synthesis and bioactivity of alkaloids
- Fluorine in Organic Chemistry
- Synthesis and Biological Activity
- Synthesis of heterocyclic compounds
- Research on Leishmaniasis Studies
- Neutropenia and Cancer Infections
- HIV/AIDS drug development and treatment
- Lung Cancer Research Studies
- Catalytic C–H Functionalization Methods
- Particle accelerators and beam dynamics
- Organophosphorus compounds synthesis
- Gyrotron and Vacuum Electronics Research
- Synthesis and Catalytic Reactions
- Click Chemistry and Applications
- Chemical Reaction Mechanisms
University of the Basque Country
2018-2022
Aarhus University
2020
This work describes, for the first time, synthesis of dialkyl (2-arylquinolin-8-yl)phosphonate derivatives. The preparation was carried out through a direct and simple process as multicomponent Povarov reaction aminophenylphosphonates, aldehydes, styrenes subsequent oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) or, alternatively, by cycloaddition between phosphonate aldimines acetylenes. Based on group structural characteristics, considered phosphorous isosteres carboxylic...
This work describes the first synthesis of diethyl 6,6a,7,11b-tetrahydro-5H-indeno[2,1-c]quinolinylphosphonates 5, 7H-indeno[2,1-c]quinolinylphosphonates 6 and 7-oxo-7H-indeno[2,1-c]quinolinylphosphonates 7, which were prepared in good to high overall yields. The synthetic route involves a multicomponent reaction 2-phosphonateaniline, aldehydes indene as olefin allows selective generation three stereogenic centres short, efficient reliable manner. dehydrogenation...
: Eukaryotic topoisomerase 1 is a potential target of anti-parasitic and anti-cancer drugs. Parasites require activity for survival and, consequently, compounds that inhibit may be interest. All effective drugs with act by inhibiting the ligation reaction enzyme. Screening targeting drugs, therefore, should involve possibility dissecting which step affected.
A new strategy is reported for the synthesis of quinolinylphosphine oxides via Povarov reaction between phosphorous aldimines and acetylenes. Moreover, these compounds were studied in vitro cytotoxicity on a human lung alveolus adenocarcinoma (A 549) cell line, demonstrating strong inhibition growth.
Minbizia heriotza-eragile nagusienen artean azaltzen da mundu mailan; 2020an, esaterako, 10 milioi heriotza inguru eragin zituen, WHO (World Health Organization) erakundearen arabera. Minbiziaren aurkako tratamendu farmakologikoari dagokionez, agente kimioterapiko eraginkorrenen balidatuta dago topoisomerasa I (TOP1, DNAren metabolismoan era zuzenean parte hartzen duen entzima) aparteko itu terapeutiko gisa. Era honetan, molekula antiproliferatibo berrien garapenerako interes handiko...