A5044876077- Vibrio bacteria research studies
- Aquaculture disease management and microbiota
- Probiotics and Fermented Foods
- Escherichia coli research studies
- Pharmacological Effects of Natural Compounds
- Cancer Research and Treatments
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Invertebrate Immune Response Mechanisms
- Marine Invertebrate Physiology and Ecology
- Salmonella and Campylobacter epidemiology
- Bone Metabolism and Diseases
- Microbial Metabolism and Applications
- Trace Elements in Health
- Digestive system and related health
- Micro and Nano Robotics
- Viral gastroenteritis research and epidemiology
- Coral and Marine Ecosystems Studies
- Bone health and osteoporosis research
- Antibiotic Resistance in Bacteria
- Galectins and Cancer Biology
- Microfluidic and Bio-sensing Technologies
- Immunotherapy and Immune Responses
- Polysaccharides and Plant Cell Walls
- Bacterial Genetics and Biotechnology
International University of Monaco
2020-2025
Scientific Centre of Monaco
2015-2025
Université Côte d'Azur
1999-2025
Centre de Gestion Scientifique
2023
Inserm
2007-2014
Centre Méditerranéen de Médecine Moléculaire
2010-2014
University of Iowa
1998
Centre National de la Recherche Scientifique
1983-1986
Summary Background Probiotics are defined as live micro‐organisms which confer a health benefit on the host. Although most probiotics bacteria, one strain of yeast, Saccharomyces boulardii , has been found to be an effective probiotic in double‐blind clinical studies. Aims To compare main properties that differentiates yeast from bacteria and review S. explaining its potential benefits probiotic. Methods The PubMed Medline databases were searched using keywords ‘probiotics’, ‘yeast’,...
ABSTRACT Use of the nonpathogenic yeast Saccharomyces boulardii in treatment infectious diarrhea has attracted growing interest. The present study designed to investigate effect this on enteropathogenic Escherichia coli (EPEC)-associated disease demonstrates that S. abrogated alterations induced by an EPEC strain transepithelial resistance, [ 3 H]inulin flux, and ZO-1 distribution T84 cells. Moreover, EPEC-mediated apoptosis epithelial cells was delayed presence . did not modify number...
Enterohemorrhagic Escherichia coli (EHEC) infections are associated with the modification of tight-junction permeability and synthesis proinflammatory cytokine interleukin-8 (IL-8). In a previous study, it was demonstrated that EHEC-induced IL-8 secretion is due to involvement mitogen-activated protein kinase (MAPK), AP-1, NF-kappaB pathways. this we investigated effect yeast Saccharomyces boulardii on EHEC infection in T84 cells. For purpose, cells were (i) incubated bacteria at same time...
Salmonella pathogenesis engages host cells in two-way biochemical interactions: phagocytosis of bacteria by recruitment cellular small GTP-binding proteins induced the bacteria, and triggering a pro-inflammatory response through activation MAPKs nuclear translocation NF-kappaB. Worldwide interest use functional foods containing probiotic for health promotion disease prevention has increased significantly. Saccharomyces boulardii is non-pathogenic yeast used as infectious diarrhea.In this...
Climate change driven seawater temperature (SWT) increases results in greater abundance and geographical expansion of marine pathogens, among which Vibrio parahaemolyticus (Vp) causes serious economic health issues. In addition, plastic pollution the ocean constitutes a vector for harmful pathogens dissemination. We investigate effect elevated SWT on expression genes implicated adhesion biofilm formation abiotic surfaces clinical Vp strain RIMD2210633, expresses hemolysins. Among studied,...
ABSTRACT Enterohemorrhagic Escherichia coli (EHEC) infections are associated with hemorrhagic colitis and the hemolytic-uremic syndrome (HUS). In vivo, elevated plasma levels of proinflammatory cytokine interleukin-8 (IL-8) in EHEC-infected children correlated a high risk developing HUS. As IL-8 gene transcription is regulated by factors NF-κB AP-1, we analyzed role these regulation production after infection epithelial intestinal T84 cell line EHEC. By 6 h infection, EHEC had induced...
An increase in wastewater rejection and rising seawater temperature are the two main causes of spreading pathogenic bacteria ocean that present a risk to health marine organisms, i.e., corals. Deciphering infectious mechanism is interest better disease management. The quantity infecting as well method pathogen administration an important parameter studying host-pathogen interactions. In this study, we have tested models infection (bathing or injection) Exaiptasia diaphana (E. diaphana) with...
Climate change driven seawater temperature (SWT) increase results in greater abundance and geographical expansion of marine pathogens, among which Vibrio parahaemolyticus (Vp) causes serious economical health issues. In addition, plastic pollution ocean constitutes a vector for harmful pathogens dissemination. We investigate the effect elevated SWT on expression genes implicated adhesion biofilm formation abiotic surfaces clinical Vp strain RIMD2210633, that express hemolysins. Among gene...
ABSTRACT Enteropathogenic Escherichia coli (EPEC) infection of T84 cells induces a decrease in transepithelial resistance, the formation attaching and effacing (A/E) lesions, cytokine production. The purpose this study was to investigate ability EPEC activate mitogen-activated protein (MAP) kinases correlate these signaling pathways with EPEC-induced cell responses. were infected either wild-type (WT) strain E2348/69 or two mutants, intimin deletion CVD206 (Δ eaeA ) type III secretion...
Background Motility is an important component of Salmonella enterica serovar Typhimurium (ST) pathogenesis allowing the bacteria to move into appropriate niches, across mucus layer and invade intestinal epithelium. In vitro, flagellum-associated motility closely related invasive properties ST. The probiotic yeast Saccharomyces boulardii BIOCODEX (S.b-B) widely prescribed for prophylaxis treatment diarrheal diseases caused by or antibiotics. case infection, S.b-B has been shown decrease ST...
Bone destruction is a hallmark of chronic inflammation, and bone-resorbing osteoclasts arising under such condition differ from steady-state ones. However, osteoclast diversity remains poorly explored. Here, we combined transcriptomic profiling, differentiation assays in vivo analysis mouse to decipher specific traits for inflammatory osteoclasts. We identified validated the pattern-recognition receptors (PRR) Tlr2, Dectin-1, Mincle, all involved yeast recognition as major regulators showed...
Intestinal epithelial cell damage is frequently seen in the mucosal lesions of inflammatory bowel diseases such as ulcerative colitis or Crohn's disease. Complete remission these requires both cessation inflammation and migration enterocytes to repair damaged epithelium. Lyophilized Saccharomyces boulardii (Sb, Biocodex) a nonpathogenic yeast widely used therapeutic agent for treatment prevention diarrhea other gastrointestinal disorders. In this study, we determined whether Sb could...
Salmonella enterica serovar Typhimurium (ST) is an enteropathogenic Gram-negative bacterium that causes infection following oral ingestion. ST spreads rapidly along the gastrointestinal tract (GIT) and invades intestinal epithelium to ultimately reach internal body organs. The probiotic yeast Saccharomyces boulardii BIOCODEX (S.b-B) prescribed for prophylaxis of diarrheal infectious diseases. We previously showed S.b-B prevents weight loss in ST-infected mice significantly decreases...
Intestinal epithelial cell damage is frequently seen in the mucosal lesions of infectious or inflammatory bowel diseases such as ulcerative colitis Crohn's disease. Complete remission these requires both disappearance inflammation and repair damaged epithelium. Saccharomyces boulardii (Sb, Biocodex) a non-pathogenic yeast widely used preventive therapeutic probiotic for prevention treatment diarrhea other gastrointestinal disorders. We recently showed that it enhances intestinal epithelium...