A5001935974- Inflammasome and immune disorders
- Immune cells in cancer
- Acute Myeloid Leukemia Research
- Phagocytosis and Immune Regulation
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Chemokine receptors and signaling
- Cell death mechanisms and regulation
- Endoplasmic Reticulum Stress and Disease
- Nuclear Structure and Function
- Epigenetics and DNA Methylation
- Blood disorders and treatments
- Immune Response and Inflammation
- Autophagy in Disease and Therapy
- Retinoids in leukemia and cellular processes
- Heme Oxygenase-1 and Carbon Monoxide
- Streptococcal Infections and Treatments
- Immune Cell Function and Interaction
- Genetics and Neurodevelopmental Disorders
- Hematopoietic Stem Cell Transplantation
- Protease and Inhibitor Mechanisms
- Macrophage Migration Inhibitory Factor
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Interference and Gene Delivery
Inserm
2020-2025
Centre Méditerranéen de Médecine Moléculaire
2018-2025
Université Côte d'Azur
2021-2025
Institut de Chimie de Nice
2023
Observatoire de la Côte d’Azur
2022
Abstract CSF-1 and IL-34 share the receptor no differences have been reported in signaling pathways triggered by both ligands human monocytes. promotes differentiation survival of monocytes, macrophages osteoclasts, as does. However, binds other receptors, suggesting that exist effect cytokines. In present study, we compared polarization abilities primary monocytes response to or IL-34. CSF-1R engagement one leads AKT caspase activation autophagy induction through expression AMPK ULK1. As...
Transcription factor EB (TFEB) is a key transcription that orchestrates the cellular response to stress. Dysregulation of TFEB associated with range human diseases, and understanding regulatory mechanisms crucial for identifying potential drug targets. In this study, we used Caenorhabditis elegans screen E3 ubiquitin ligases regulating activity TFEB's homolog, HLH-30, upon pathogenic infection. We identified WWP-1 as regulator HLH-30-dependent immune controlling HLH-30 stability mediate host...
A growing number of patients presenting severe combined immunodeficiencies attributed to monoallelic RAC2 variants have been identified. The expression the RHO GTPase is restricted hematopoietic lineage. described cause associated with high frequency infection, leukopenia, and autoinflammatory features. Here, we show that specific activating mutations induce NLRP3 inflammasome activation leading secretion IL-1β IL-18 from macrophages. This depends on state variant mediated by downstream...
Abstract Hematopoietic stem and progenitor cells (HSPCs) establish specific interactions with bone marrow stromal cells, leading to their polarization. Given the role of cell polarity in protection against tumorigenesis importance niche hematological disorders such as acute myeloid leukemias (AMLs), we investigated polarization capacities leukemic blasts from patients. Using engineered micro-niches centrosome position respect contact site a proxy for polarization, showed that AML lines...
Background: Cathepsin L (Ctsl) is a cysteine protease mainly located within the endosomal/lysosomal cell compartment. High expression of Ctsl indicates poor prognosis in human breast cancer. However, type-specific functions responsible for this association remain elusive. Methods: Because constitutive Ctsl−/− mice develop complex phenotype, we developed conditional model allowing inactivation mammary epithelium or myeloid cells transgenic mouse tumor virus (MMTV)-polyoma middle T (PyMT)...
Macrophages are widely distributed innate immune cells that play an indispensable role in a variety of physiologic and pathologic processes, including organ development, host defense, acute chronic inflammation, solid hematopoietic cancers. Beyond their inextricable as conveyors programmed cell death, we have previously highlighted caspases exert non-apoptotic functions, especially during the differentiation monocyte-derived response to CSF-1. Here, found non-canonic cleavages caspases,...