A5011140741- Immune cells in cancer
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- Cancer Genomics and Diagnostics
- T-cell and Retrovirus Studies
- Immune Cell Function and Interaction
- Extracellular vesicles in disease
- melanin and skin pigmentation
- Immune Response and Inflammation
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Chronic Kidney Disease and Diabetes
- Epigenetics and DNA Methylation
- Colorectal Cancer Surgical Treatments
- RNA modifications and cancer
- Single-cell and spatial transcriptomics
- Anesthesia and Neurotoxicity Research
- Muscle Physiology and Disorders
- Vascular Tumors and Angiosarcomas
- Protein Kinase Regulation and GTPase Signaling
La Ligue Contre le Cancer
2020-2025
Université Côte d'Azur
2018-2025
Observatoire de la Côte d’Azur
2019-2025
Inserm
2018-2024
Institut Curie
2020-2024
Université Paris Sciences et Lettres
2020-2024
Centre Méditerranéen de Médecine Moléculaire
2018-2021
Abstract CSF-1 and IL-34 share the receptor no differences have been reported in signaling pathways triggered by both ligands human monocytes. promotes differentiation survival of monocytes, macrophages osteoclasts, as does. However, binds other receptors, suggesting that exist effect cytokines. In present study, we compared polarization abilities primary monocytes response to or IL-34. CSF-1R engagement one leads AKT caspase activation autophagy induction through expression AMPK ULK1. As...
Abstract Although heterogeneity of FAP+ Cancer-Associated Fibroblasts (CAF) has been described in breast cancer, their plasticity and spatial distribution remain poorly understood. Here, we analyze trajectory inference, deconvolute transcriptomics at single-cell level perform functional assays to generate a high-resolution integrated map cancer (BC), with focus on inflammatory myofibroblastic (iCAF/myCAF) CAF clusters. We identify 10 spatially-organized CAF-related cellular niches, called...
Abstract Chronic kidney disease (CKD) is a public health problem driven by myofibroblast accumulation, leading to interstitial fibrosis. Heterogeneity recently recognized characteristic in fibroblasts CKD, but the role of different populations still unclear. Here, we characterize proinflammatory fibroblast population (named CXCL-iFibro), which corresponds an early state differentiation CKD. We demonstrate that CXCL-iFibro co-localize with macrophages and participate their attraction, switch...
Abstract Although cancer-associated fibroblast (CAF) heterogeneity is well-established, the impact of chemotherapy on CAF populations remains poorly understood. Here we address this question in high-grade serous ovarian cancer (HGSOC), which previously identified 4 populations. While global content stroma increases HGSOC after chemotherapy, proportion FAP + (also called CAF-S1) decreases. Still, maintenance high residual CAF-S1 associated with reduced CD8 T lymphocyte density and poor...
Cancer-associated fibroblasts (CAF) are heterogeneous with multiple functions in breast cancer. Recently, we identified a specific CAF subpopulation (referred to as CAF-S1), which promotes immunosuppression and immunotherapy resistance.Here, by studying large collection of human samples, highlight the key function CD73/NT5E CAF-S1-mediated We first reveal that CD73 protein level specifically accumulates CAF-S1 cancer patients. Interestingly, infiltration regulatory T lymphocytes (Tregs) is...
Cancer cell survival and proliferation are correlated with increased metabolic activity consequent oxidative stress, driving shifts that interfere the immune response to malignant cells. This is case of high-energy-demanding angioimmunoblastic T lymphoma (AITL), a highly aggressive cancer poor rates, where CD4+ PD-1high cells show mitochondrial Reactive oxygen species (ROS) accumulation. Here, we report administration ROS scavenging cerium oxide (CeO2) nanoparticles in an AITL preclinical...
Abstract T cells represent a valuable tool for treating cancers and infectious inherited diseases; however, they are mainly short-lived in vivo. T-cell therapies would strongly benefit from gene transfer into long-lived persisting naive or progenitors. Here we demonstrate that baboon envelope glycoprotein pseudotyped lentiviral vectors (BaEV-LVs) far outperformed other LV pseudotypes transduction of adult fetal interleukin-7–stimulated cells. Remarkably, BaEV-LVs efficiently transduced...
IRE1α is one of the three ER transmembrane transducers Unfolded Protein Response (UPR) activated under endoplasmic reticulum (ER) stress. activation has a dual role in cancer as it may be either pro- or anti-tumoral depending on studied models. Here, we describe discovery that exogenous expression IRE1α, resulting auto-activation, did not affect cell proliferation vitro but resulted tumor-suppressive phenotype syngeneic immunocompetent mice. We found murine colorectal and Lewis lung...
Myocardial ischemia/reperfusion (I/R) injury is a frequent perioperative threat, with numerous strategies developed to limit and/or prevent it. One interesting axis of research the anesthetic preconditioning (APc) agent's hypothesis (such as sevoflurane, SEV). However, APc's mode action still poorly understood and volatile anesthetics used agents are often not well suited in clinical practice. Here, vitro using H9C2 cells lines (in myeloblast state or differentiated toward cardiomyocytes)...
Abstract Cancer metabolic reprogramming has been recognized as one of the cancer hallmarks that promote cell proliferation, survival, well therapeutic resistance. Up-to-date regulation metabolism in T-cell lymphoma is poorly understood. In particular, for human angioimmunoblastic (AITL) profile not known. Metabolic intervention could help identify new treatment options this with very poor outcomes and no effective medication. Transcriptomic analysis AITL tumor cells, identified these cells...
Invasive lobular carcinoma (ILC) shows distinct clinicopathological features compared to invasive breast of no special type (IBC-NST), including specific stromal characteristics. One them concerns the singular infiltration pattern tumor cells, which induces minimal reaction. In addition, a key function microenvironment has been previously demonstrated reporting that tumor-infiltrating lymphocytes (TIL) is associated with poor prognosis in ILC. So far, precise impact E-cadherin inactivation...
Numerous combinations of signaling pathway blockades in association with tyrosine kinase inhibitor (TKI) treatment have been proposed for eradicating leukemic stem cells (LSCs) chronic myeloid leukemia (CML), but none are currently clinically available. Because targeting protein Cδ (PKCδ) was demonstrated to eliminate cancer (CSCs) solid tumors, we evaluated the efficacy PKCδ inhibition combination TKIs CML cells. We observed that by a pharmacological inhibitor, gene silencing, or using K562...