A5050858115- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Glioma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Glycosylation and Glycoproteins Research
- Immune cells in cancer
- Protein Degradation and Inhibitors
- Immunotherapy and Immune Responses
- Phagocytosis and Immune Regulation
- RNA regulation and disease
- COVID-19 Clinical Research Studies
- Galectins and Cancer Biology
- Mitochondrial Function and Pathology
- Pancreatic function and diabetes
- Cellular transport and secretion
- Reproductive System and Pregnancy
- SARS-CoV-2 and COVID-19 Research
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- CAR-T cell therapy research
- Sarcoma Diagnosis and Treatment
- Redox biology and oxidative stress
- Advanced Proteomics Techniques and Applications
- Adenosine and Purinergic Signaling
Oncogenesis Stress Signaling
2015-2024
Université de Rennes
2015-2024
Inserm
2015-2024
Centre Eugène Marquis
2015-2024
Institut de génétique et de développement de Rennes
2012-2014
Centre National de la Recherche Scientifique
2012-2014
Hôpital Pontchaillou
2012
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2012
Hôpital Cardiologique du Haut-Lévêque
2012
Gefluc Languedoc Roussillon
2011
Abstract Siglec‐7 is a sialic acid binding receptor with inhibitory potential, expressed on human NK cells and monocytes. It has an unusual preference for α2,8‐linked disialic acids, such as those displayed by ganglioside GD3. Here we have investigated whether siglec‐7‐GD3 interactions are able to modulate cell cytotoxicity. Using synthetic polyacrylamide glycoprobes, siglec‐7 was found be masked at the surface but it could unmasked sialidase treatment of cells. GD3 synthase‐transfected P815...
Abstract Siglec-7 and Siglec-9 are two members of the recently characterized CD33-related Siglec family sialic acid binding proteins both expressed on human monocytes NK cells. In addition to their ability recognize residues, these Siglecs display conserved tyrosine-based motifs in cytoplasmic region similar those found inhibitory receptors immune system. present study, we use rat basophilic leukemia (RBL) model examine potential Siglecs-7 -9 function as investigate molecular basis for this....
Research Article8 January 2018Open Access Transparent process Dual IRE1 RNase functions dictate glioblastoma development Stéphanie Lhomond Université de Bordeaux, France Search for more papers by this author Tony Avril INSERM U1242, "Chemistry, Oncogenesis, Stress, Signaling", Rennes 1, Rennes, Centre Lutte Contre le Cancer Eugène Marquis, Nicolas Dejeans Konstantinos Voutetakis Institute of Biology, Medicinal Chemistry & Biotechnology, NHRF, Athens, Greece Department Biochemistry University...
siglecs are a family of sialic-acid binding immunoglobulin-like lectins mostly expressed by cells the immune system that have potential to interact with sialylated glycans not only on host but also certain pathogens. Campylobacter jejuni is common pathogen humans expresses surface lipooligosaccharides (LOS) can be modified ganglioside-like terminal structures in core oligosaccharides. In this study, we examined interaction 10 LOS purified from four different C. isolates expressing GM1-like,...
Glioblastoma multiforme (GBM) is the most dramatic primary brain cancer with a very poor prognosis because of inevitable disease recurrence. The median overall survival less than 1 year after diagnosis. Cancer stem cells have recently been disclosed in GBM. GBM stem-like (GSCs) exhibit resistance to radio/chemotherapeutic treatments and are therefore considered play an important role GSCs thus appealing targets for new patients. In this study, we show that cell characteristics resistant...
The extracellular matrix (ECM) plays an instrumental role in determining the spatial orientation of epithelial polarity and formation lumens glandular tissues during morphogenesis. Here, we show that Endoplasmic Reticulum (ER)-resident protein anterior gradient-2 (AGR2), a soluble protein-disulfide isomerase involved ER folding quality control, is secreted interacts with ECM. Extracellular AGR2 (eAGR2) microenvironmental regulator tissue architecture, which preneoplastic phenotype...
Glioblastoma (GB) displays diffusely infiltrative growth patterns. Dispersive cells escape surgical resection and contribute to tumour recurrence within a few centimeters of the cavity in 90% cases. We know that non-neoplastic stromal compartment, addition cells, plays an active role recurrence. isolated new cell population from histologically normal margins GB by computer-guided stereotaxic biopsies primary culture. These GB-associated (GASCs) share phenotypic functional properties with...
Research Article30 April 2019Open Access Transparent process Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation Marion Maurel INSERM U1242, “Chemistry, Oncogenesis Stress Signaling”, University Rennes, France Centre de Lutte Contre le Cancer Eugène Marquis, VIB Department Medical Protein Research, UGent, Gent, Belgium Apoptosis Centre, School Natural Sciences, NUI Galway, Ireland Search for more papers by this author Joanna Obacz Tony...
Inositol-requiring enzyme 1 (IRE1) is a major mediator of the unfolded protein response (UPR), which activated upon endoplasmic reticulum (ER) stress. Tumor cells experience ER stress due to adverse microenvironmental cues, overcome by relying on IRE1 signaling as an adaptive mechanism. Herein, we report discovery structurally new inhibitors identified through structural exploration its kinase domain. Characterization in vitro and cellular models showed that they inhibit sensitize...
Siglec-5 (CD170) is a member of the recently described human CD33-related siglec subgroup sialic acid binding Ig-like lectins and expressed on myeloid cells hemopoietic system. Similar to other siglecs, contains two tyrosine-based motifs in its cytoplasmic tail implicated signaling functions. To investigate role these Siglec-5-dependent signaling, we used transfected rat basophil leukemia as model Tyrosine phosphorylation led recruitment tyrosine phosphatases SHP-1 SHP-2, seen both pull-down...