A5013871206- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Psoriasis: Treatment and Pathogenesis
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Diet, Metabolism, and Disease
- Cytomegalovirus and herpesvirus research
- CAR-T cell therapy research
- Celiac Disease Research and Management
- Immune Response and Inflammation
- Cell death mechanisms and regulation
- Genetics, Aging, and Longevity in Model Organisms
- Autoimmune Bullous Skin Diseases
- Cutaneous Melanoma Detection and Management
- Digestive system and related health
- Rheumatoid Arthritis Research and Therapies
- Microscopic Colitis
- Immunodeficiency and Autoimmune Disorders
- Cytokine Signaling Pathways and Interactions
- Microtubule and mitosis dynamics
- Chronic Lymphocytic Leukemia Research
- Endoplasmic Reticulum Stress and Disease
- Urticaria and Related Conditions
Thomas Jefferson University
2019-2024
Sidney Kimmel Cancer Center
2019-2021
Université Côte d'Azur
2018
Inserm
2018
Centre Méditerranéen de Médecine Moléculaire
2018
Center of Molecular Immunology (Cuba)
2014-2017
Instituto de Medicina Tropical “Pedro Kourí”
2012
IL-10+ B cells are critical for immune homeostasis and restraining responses in infection, cancer, inflammation; however, the signals that govern cell differentiation ill-defined. Here we find expand mice lacking secreted IgM ((s)IgM-/-) up to 10-fold relative wildtype (WT) among all major regulatory subsets. The increase is polyclonal presents within 24 hours of birth. In WT mice, sIgM produced prenatally limits expansion cells. Lack high affinity receptor sIgM, FcμR, translates into an...
Psoriasis is a chronic inflammatory disease with prevalence of approximately 2–3% in the general population. The majority diagnosed patients have plaque psoriasis, and about 20% moderate-to-severe disease. Itolizumab, new monoclonal antibody specific for CD6 molecule mainly expressed on T lymphocytes, has demonstrated to inhibit vitro ligand-induced proliferation pro-inflammatory cytokine production. We assessed immunological histopathological effect using clinical samples taken from 26...
Summary Itolizumab is a humanized anti-CD6 monoclonal antibody (mAb) that has previously shown encouraging results, in terms of safety and positive clinical effects, 6-week monotherapy trial conducted rheumatoid arthritis (RA) patients. The current Phase I study evaluated the response for longer treatment 12 itolizumab intravenous doses subjects with active RA despite previous disease-modifying anti-rheumatic drug (DMARD) therapy. Twenty-one were enrolled into four dosage groups (0·1, 0·2,...
Abstract Coeliac disease and type 1 diabetes are autoimmune diseases that may share the same initiating environmental factors. In this study, occurrence of associated autoantibodies (GADA IA‐2A) tissue transglutaminase (TGA) was determined in patients with confirmed viral infections no signs or coeliac disease. Serum samples from 82 Cuban tested positive for PCR IgG specific to enterovirus (HEV, serotype echovirus 16, 20 samples), Epstein–Barr virus (EBV, cytomegalovirus (CMV, 21 hepatitis C...
Rheumatoid arthritis is an autoimmune disease characterized by joint inflammation that affects approximately 1% of the general population. Itolizumab, a monoclonal antibody specific for human CD6 molecule mainly expressed on T lymphocytes, has been shown to inhibit proliferation cells and proinflammatory cytokine production in psoriasis patients. We have now assessed immunological effect itolizumab combination with methotrexate rheumatoid analyzing clinical samples taken from 30 patients...
Abstract Regulatory B cells (Bregs) limit inflammatory responses in various organs. While most studies suggest that Bregs exert their anti-inflammatory functions by virtue of IL-10 production lymphoid tissues such as spleen and lymph nodes, we found producing reside constitutively skin are preferentially recruited inflammation an α4β1 integrin-dependent manner. To address whether suppress at the effector site (i.e. inflamed skin), employed mice with inducible B-cell specific deletion...
Abstract Regulatory B cells (Bregs) are critical for maintaining immune tolerance, and alterations in Breg numbers has detrimental effects inflammatory diseases, infection, cancer. Bregs found among most cell subsets act primarily by producing IL-10. Despite their importance, the signals that control differentiation maintenance not well defined. Here, we demonstrate mice incapable of secreting IgM (sIgM−/−) have drastically increased IL-10+ lymphoid organs compared to wildtype (WT) mice....