A5101950376- Autophagy in Disease and Therapy
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Psoriasis: Treatment and Pathogenesis
- IgG4-Related and Inflammatory Diseases
- Diet, Metabolism, and Disease
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroendocrine Tumor Research Advances
- Metabolism, Diabetes, and Cancer
- Digestive system and related health
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Celiac Disease Research and Management
- Congenital Ear and Nasal Anomalies
- Protein Degradation and Inhibitors
- Fuel Cells and Related Materials
- Pancreatic function and diabetes
- Abdominal vascular conditions and treatments
- Liver Disease and Transplantation
- Retinoids in leukemia and cellular processes
- Cannabis and Cannabinoid Research
- Pituitary Gland Disorders and Treatments
- Adenosine and Purinergic Signaling
Hospital Garcia de Orta
2013-2021
Université Côte d'Azur
2011-2018
Inserm
2012-2018
Centre Méditerranéen de Médecine Moléculaire
2012-2016
La Ligue Contre le Cancer
2012-2016
Infection et inflammation
2014
Laboratoire CarMeN
2014
Université Claude Bernard Lyon 1
2013
Université de Lyon
2012
Institut de Recherche sur le Cancer et le Vieillissement de Nice
2011
Autophagy is induced during differentiation of human monocytes into macrophages that mediated by CSF1/CSF-1/M-CSF (colony stimulating factor 1 [macrophage]). However, little known about the molecular mechanisms link CSF1 receptor engagement to induction autophagy. Here we show CAMKK2-PRKAA1-ULK1 pathway required for CSF1-induced autophagy and monocyte differentiation. We reveal this links P2RY6 autophagy, decipher signaling network P2RY6-mediated In addition, physiological ligand UDP...
Crohn disease (CD) ileal lesions are colonized by adherent-invasive E. coli (AIEC) that locally induce inflammation. Hypoxia inducible factor (HIF)-1alpha protein is expressed in acute and chronically inflamed site; however the molecular basis of this expression not fully understood. The aim study was to access whether AIEC HIF-1α consequence on onset pathogenesis. We show maximally epithelium CD-patients. CEACAM6, a acts as receptor AIEC, particular condition. Using CEABAC 10 transgenic...
The detection of the activities pathogen-encoded virulence factors by innate immune system has emerged as a new paradigm pathogen recognition. Much remains to be determined with regard molecular and cellular components contributing this defense mechanism in mammals importance during infection. Here, we reveal central role IL-1β signaling axis Gr1+ cells controlling Escherichia coli burden blood response sensing Rho GTPase-activating toxin CNF1. Consistently, is abrogated...
Multiple myeloma (MM) evolves from a premalignant condition known as monoclonal gammopathy of undetermined significance (MGUS). However, the factors underlying malignant transformation plasmocytes in MM are not fully characterized. We report here that Eµ-directed expression antiapoptotic Bcl-B protein mice drives an phenotype reproduces accurately human disease. Indeed, with age, Eµ-bcl-b transgenic develop characteristic features MM, including bone plasma cell infiltration, immunoglobulin...
Sympathetic paragangliomas are rare catecholamine-secreting tumors of extra-adrenal origin, and their diagnosis in children is even more infrequent. They usually manifest as hypertension, palpitations, headache, sweating, pallor. Malignant identified by the presence metastasis. Hemorrhagic stroke pediatric population a life-threatening condition with several etiologies. We report here case 12-year-old boy malignant sympathetic paraganglioma presenting hemorrhagic stroke. Severe hypertension...
Hashimoto’s thyroiditis (HT) has been characterized for many years as a well-defined clinicopathologic entity, but is now considered heterogeneous disease. IgG4-related HT new subtype by thyroid inflammation rich in IgG4-positive plasma cells and marked fibrosis. It may be part of the systemic We report case 56-year-old Portuguese man who presented with one-month history progressive neck swelling dysphagia. Laboratory testing revealed increased inflammatory parameters, subclinical...
Celiac disease (CD) is a chronic immune-mediated enteropathy driven by gluten and affecting individuals of all ages. The diagnosis CD in adulthood emerging patients often present with nonclassical extraintestinal manifestations. We report the case 53-year-old man presenting neuromuscular symptoms, skin rash, inconspicuous diarrhea, marked weight loss, biochemical markers malabsorption. A strong clinical suspicion led to recovery after initiation gluten-free diet. Clinical presentation...
Transgenic mice expressing the caspase-cleaved form of tyrosine kinase Lyn (LynΔN) develop a TNFα-dependent skin disease that accurately recapitulates human psoriasis. Participation lymphocytes in this was confirmed by backcrossing LynΔN on Rag-1 deficient background. The present study therefore conducted to analyze whether modification lymphocyte homeostasis does occur and participate phenotype mice. We show here consistently exhibit thymic atrophy correlates with both net decrease...
Hypercalcaemia is a frequent finding in malignancies including lymphomas. However, there are no reports of hypercalcaemia hepatosplenic T-cell lymphoma (HSTCL). HSTCL rare and aggressive neoplasm which usually difficult to diagnose. We present case was the initial presentation.Hepatosplenic (HSTCL) diagnose, has poor prognosis presents with hepatosplenomegaly, B symptoms cytopenias.Hypercalcaemia an extremely clinical presentation HSTCL.Severe life-threatening condition should always be...