A5088974956- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Health and Lifestyle Studies
- Celiac Disease Research and Management
- Pharmacology and Obesity Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Immunodeficiency and Autoimmune Disorders
- Eating Disorders and Behaviors
- Metabolism and Genetic Disorders
- Immune Cell Function and Interaction
- Viral Infections and Immunology Research
- Digestive system and related health
- Diet, Metabolism, and Disease
- Viral gastroenteritis research and epidemiology
- Hormonal and reproductive studies
- Natural Antidiabetic Agents Studies
- Medicine, History, and Philosophy
- Medicine and Dermatology Studies History
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Public Health in Brazil
- High Altitude and Hypoxia
- Sirtuins and Resveratrol in Medicine
Universidad de Ciencias Médicas de la Habana
2023-2024
Institute of Endocrinology
1997-2022
National Center for Genetic Engineering and Biotechnology
2007
Zapata (United States)
1997
Background: The penetrance of type 1 diabetes mellitus (T1DM) in a genetically susceptible population is largely determined by environmental influences amongst which the human enteroviruses are prominent putative factors.Aim/hypothesis: aim this study was to determine occurrence enterovirus RNA serum children with at onset and ICA-positive subjects low incidence high circulation enteroviruses.Subjects methods: Serum samples were collected from newly diagnosed (n = 34); islet...
Abstract Coeliac disease and type 1 diabetes are autoimmune diseases that may share the same initiating environmental factors. In this study, occurrence of associated autoantibodies (GADA IA‐2A) tissue transglutaminase (TGA) was determined in patients with confirmed viral infections no signs or coeliac disease. Serum samples from 82 Cuban tested positive for PCR IgG specific to enterovirus (HEV, serotype echovirus 16, 20 samples), Epstein–Barr virus (EBV, cytomegalovirus (CMV, 21 hepatitis C...
Type 1 diabetes associated genes account for less than 50% of disease susceptibility. Human enteroviruses have been implicated as environmental factors that might trigger and/or accelerate this autoimmune disorder. We now report a 12-year-old girl developed pancreatic autoimmunity and type after enteroviral infection. Diabetes-associated was evaluated by measurement several islet cell related autoantibodies. Neutralizing antibodies to different were determined in the case eight children...
Several experimental studies in rats have demonstrated that sulfonylurea treatment increases autoantigen expression B-cells. This phenomenon may be deleterious for the preservation of residual beta cell function patients with slowly progressing type 1 diabetes or latent autoimmune adult (LADA).The aim present study was to evaluate whether exclusion glibenclamide ICA positive 2 diabetic diminish halt humoral response against B-cells as well improve metabolic control and insulin...
Background: Nicotinamide has been used with success to prevent type 1 diabetes in animal models and humans. This vitamin B3 derivative attracting effects on β-cell protection regeneration.Aim/hypothesis: To evaluate the effect of standard nicotinamide administration prevention first degree relatives persons as well concentrations islet-cell-related autoantibodies, insulin secretion peripheral sensitivity.Subjects methods: A randomized double-blind placebo controlled intervention trial was...
Background: Incidence of type 1 diabetes varies widely around the world, probably due to ethnic differences across populations among other factors.Aims: To determine whether there is an association between disease and ancestry proportions; control disease–HLA associations for possible confounding by admixture or population stratification.Subjects methods: 100 cases 129 controls participated in study. Ancestry informative markers, which have considerable frequency European, West African...
A possible etiologic role of enteroviruses for type 1 diabetes has been researched 40 years, but evidence to date is inconclusive. This article summarizes new from Cuban research supporting a enteroviruses, both in preclinical stages autoimmune reactions against pancreatic β cells and at clinical onset, population with low incidence. Possible pathogenetic mechanisms are also discussed, such as acute cytolytic damage molecular mimicry. Although direct causal effects difficult demonstrate,...
While human enteroviruses are generally regarded as a lytic virus, and persistent non-cytolytic enterovirus infection in pancreatic beta cells has been suspected of playing role type 1 diabetes pathogenesis. However, it is still unclear how could exit the cell non-lytic manner. This study aimed to investigate cell-derived extracellular vesicles (EVs) enteroviral spread infection. Size-exclusion chromatography antibody-based immunoaffinity purification were used isolate EVs from echovirus...
Three large-scale Echovirus (E) epidemics (E4,E16,E30), each differently associated to the acute development of diabetes related autoantibodies, have been documented in Cuba. The prevalence islet cell autoantibodies was moderate during E4 epidemic but high E16 and E30 epidemic. aim this study evaluate effect strains echovirus on beta-cell lysis, function innate immunity gene expression primary human pancreatic islets. Human islets from non-diabetic donors (n = 7) were infected with virus E4,...
Objectives. The aim of this study was to determine the level diagnostic concordance between seven definitions metabolic syndrome (MS) in a group overweight and obese adults. Materials Methods. 350 subjects aged from 19 70 years were recruited for clinic subjects. MS used those given by WHO (World Health Organization), EGIR (European Group Study Insulin Resistance), NCEPATPIII (Adult Treatment Panel), AHA/NHLBI (American Heart Association), IDF (International Diabetes Federation), JIS (Joint...
In an earlier study, infection of human pancreatic islets with epidemic strains echovirus (E4, E16, E30), proven but differently ability to induce islet autoimmunity, resulted either in a severe damage (i.e., E16 and E30) or proceeded without visible changes infected E4). this the these replicate beta cells consequence such for cell lysis function was studied lines INS‐1, MIN6, NIT‐1. The E30 did INS1, NIT1 pronounced cytopathic effect within 3 days following infection. By contrast, E4...
Background: Celiac Disease (CD) is present in 1–16.4% of patients with type 1 diabetes mellitus. The most important serological markers CD are anti-endomysial (EMA), anti-tissue transglutaminase (tTGA) and antigliadin antibodies (AGA).Aim/hypothesis: objective this work to determine the frequency tTGA and/or AGA latent autoimmune adult (LADA) subjects 2 (T2DM), as well evaluate their relation several clinical biochemical characteristics.Subjects Methods: Forty three LADA 99 T2DM were...
Human enteroviruses (HEV), especially coxsackievirus serotype B (CVB) and echovirus (E), have been associated with diseases of both the exocrine endocrine pancreas, but so far evidence on HEV infection in human pancreas has reported only islets ductal cells. This study aimed to investigate capability strains infect pancreatic Infection explanted cells seven field E6 caused cytopathic effect, virus titer increase production protein VP1 cell types. Virus particles were found acinar infected...
The aim of the present study was to determine whether administration Diamel, marketed as a food supplement by Catalysis Laboratories (Madrid, Spain) could improve any components metabolic syndrome (MS), well insulin resistance and sensitivity.In all, 100 patients with MS (19-70 years age) who satisfied World Health Organization criteria for were included in study. Participants randomly assigned receive either oral Diamel or placebo (while maintaining diet appropriate their weight physical...
For to determine the effect of Diamel on insulin resistance, sensitivity, and sexual hormones results in women with polycystic ovary syndrome (PCOS). A study was carried out 37 patients this disorder. triple-blind clinical trial designed which food supplement compared a placebo. The reproductive ages were randomly distributed two groups, 18 19 respectively, they took or placebo followed up during 6 months biochemical evaluation. significant decrease HOMA-IR from initial value at six observed...
Obex is a dietary supplement to help weight loss. The purpose of this study was evaluate the effect in overweight/obese participants with or without impaired fasting glucose. This an open-label pilot conducted 40 overweight and obese subjects, 23–60 years old body mass index 25–44 kg/m2 (20 glucose [IFG] 20 normal levels). Participants received at dose one sachet before two main meals each day for 3 months. In addition anthropometric measures blood pressure (BP), plasma glucose, lipid...
It has been recently suggested that pancreatic glycolipidic extracts and acidic glycolipid fractions are able to block the binding of ICA frozen sections human pancreas. We study prevalence blocking effect by upper-phase from (PGE) in thirty-eight sera positive seventeen IDDM patients twenty-one first relatives type 1 diabetics. Total inhibition was found 82% 76% insulin dependent diabetes mellitus diabetics respectively. Partial no ICA+ seen 6%, 12% 19%, 5% degree Our suggests there is...