A5054373904- Click Chemistry and Applications
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Biochemical and Molecular Research
- Chemical Synthesis and Analysis
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Crystallization and Solubility Studies
- HIV/AIDS drug development and treatment
- X-ray Diffraction in Crystallography
- Histone Deacetylase Inhibitors Research
- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Chemical Synthesis and Reactions
- Microwave-Assisted Synthesis and Applications
- Extraction and Separation Processes
- Radioactive element chemistry and processing
- RNA Interference and Gene Delivery
- Minerals Flotation and Separation Techniques
- Autophagy in Disease and Therapy
- Renal cell carcinoma treatment
- Quinazolinone synthesis and applications
- Mine drainage and remediation techniques
- Membrane Separation Technologies
- Enzyme Production and Characterization
Institut de Chimie de Nice
2016-2025
Université Côte d'Azur
2016-2025
Centre National de la Recherche Scientifique
2016-2025
Université Mohammed VI Polytechnique
2017-2025
Polytechnic University
2021-2025
Biochemical Society
2025
National Council for Scientific Research
2025
Institut de Biologie Valrose
2023-2024
Hôpital Saint Roch
2022-2024
Observatoire de la Côte d’Azur
2016-2021
Metastatic renal cell carcinomas (mRCC) are highly vascularized tumors that a paradigm for the treatment with antiangiogenesis drugs targeting vascular endothelial growth factor (VEGF) pathway. The available increase time to progression but not curative and patients eventually relapse. In this study we have focused our attention on molecular mechanisms leading resistance sunitinib, first line of mRCC. Because anarchic vascularization core mRCC receives only suboptimal concentrations drug. To...
MicroRNAs (miRNAs) are a recently discovered category of small RNA molecules that regulate gene expression at the post-transcriptional level. Accumulating evidence indicates miRNAs aberrantly expressed in variety human cancers and revealed to be oncogenic play pivotal role initiation progression these pathologies. It is now clear inhibition miRNAs, defined as blocking their biosynthesis or function, could find an application therapy different types cancer which implicated. Here we report...
Abstract Background In clear cell renal carcinoma (ccRCC), first-line treatment combines nivolumab (anti-PD-1) and ipilimumab (anti-CTLA4), yielding long-term remissions but with only a 40% success rate. Our study explored the potential of enhancing ccRCC by concurrently using CXCR2 inhibitors alongside immunotherapies. Methods We analyzed ELR + CXCL levels their correlation patient survival during immunotherapy. RCT001, unique inhibitor, was examined for its mechanism action, particularly...
With the aim of developing a new tool to investigate DNA interactions, nucleoside analogue incorporating 3-hydroxychromone (3HC) fluorophore as nucleobase mimic was synthesized and incorporated into oligonucleotide chains. In comparison with existing fluorescent analogues, this dye features exceptional environmental sensitivity switching between two well-resolved fluorescence bands. labeled DNA, does not alter duplex conformation exhibits high quantum yield. This probe is up 50-fold brighter...
The coronavirus pandemic, which appeared in Wuhan, China, December 2019, rapidly spread all over the world only a few weeks. Faster testing techniques requiring less resources are key managing either to enable larger scale or even just provide developing countries with limited resources, particularly Africa, means perform tests manage crisis. Here, we report an unprecedented, rapid, reagent-free and easy-to-use screening spectroscopic method for detection of SARS-CoV-2 on RNA extracts. This...
Phosphogypsum (PG) is the largest by-product of phosphate industry. Nearly 300 M tons PG are annually discarded, which 58% dry stacked. The exposure stacks to rainwater and processed waters moisture creates hydraulic pressure, generating acidic leachates into nearby aquifer systems. Because its elevated levels sulfates, phosphorus (P) heavy metals, water leachate can negatively affect surrounding environments. This work investigates effect activity on leaching, by studying different PG:Water...
Abstract MicroRNAs (miRNAs) are a recently discovered category of small RNA molecules that regulate gene expression at the post‐transcriptional level. Accumulating evidence indicates miRNAs aberrantly expressed in variety human cancers and inhibition these oncogenic could find application therapy different types cancer. Herein, we describe synthesis biological evaluation new small‐molecule drugs target production. In particular, chose to two (i.e., miRNA‐372 ‐373) implicated various cancer,...
Bis(trichlorosilyl)phosphine (HP(SiCl3)2, 1) was prepared from [TBA][P(SiCl3)2] ([TBA]2, TBA = tetra-n-butylammonium) and triflic acid in 36% yield. Phosphine 1 is an efficient reagent for hydrophosphination of unactivated terminal olefins under UV irradiation (15-60 min) gives rise to bis(trichlorosilyl)alkylphosphines (RP(SiCl3)2, R (CH2)5CH3, 88%; (CH2)7CH3, 98%; (CH2)2C(CH3)3, 76%; CH2Cy, 93%; (CH2)2Cy, 95%; CH2CH(CH3)(CH2)2CH3, 82%; (CH2)3O(CH2)3CH3, (CH2)3Cl, 83%; (CH2)2SiMe3, 92%;...