The pyridyl group has been extensively employed to direct transition-metal-catalyzed C-H activation reactions in the past half-century. typical cyclic transition states involved these cyclometalation processes have only enabled of ortho-C-H bonds. Here, we report that pyridine is adapted meta-C-H benzyl and phenyl ethyl alcohols through engineering distance geometry a directing template. This template takes advantage stronger σ-coordinating recruit Pd catalysts desired site for...

A quinoline-based ligand was shown to promote palladium-catalyzed β-C(sp(3))-H fluorination for the first time. range of unnatural enantiopure fluorinated α-amino acids were obtained through sequential arylation and subsequent stereoselective from readily available L-alanine.

Pd-catalyzed C(sp3)-H activation of alcohol typically shows β-selectivity due to the required distance between chelating atom in attached directing group and targeted C-H bonds. Herein we report design a hemilabile which exploits chelation readily removable benzyl ether moiety direct γ- or δ-C-H carbonylation olefination alcohols. The utility this approach is also demonstrated late-stage functionalization β-estradiol rapidly prepare desired analogues that multi-step syntheses with classical methods.

Bis(trichlorosilyl)phosphine (HP(SiCl3)2, 1) was prepared from [TBA][P(SiCl3)2] ([TBA]2, TBA = tetra-n-butylammonium) and triflic acid in 36% yield. Phosphine 1 is an efficient reagent for hydrophosphination of unactivated terminal olefins under UV irradiation (15-60 min) gives rise to bis(trichlorosilyl)alkylphosphines (RP(SiCl3)2, R (CH2)5CH3, 88%; (CH2)7CH3, 98%; (CH2)2C(CH3)3, 76%; CH2Cy, 93%; (CH2)2Cy, 95%; CH2CH(CH3)(CH2)2CH3, 82%; (CH2)3O(CH2)3CH3, (CH2)3Cl, 83%; (CH2)2SiMe3, 92%;...

Abstract Currently, meat production involves environmental issues and high costs; one solution to address this may be produce via cell culture. Therefore, there is an urgent demand for the development of culture methods that replace raw materials with food cultured as food. In study, we designed food-grade-Dulbecco’s Modified Eagle’s Medium (FG-DMEM); when cells in FG-DMEM regular DMEM were compared, was no significant difference growth or differentiation. can used research safe meat.

Azophosphines (Ar–N═N–PR2) were prepared from N-aryl-N′-(trimethylsilyl)diazenes (Ar–N═N–SiMe3) and R2PCl by Me3SiCl elimination or oxidation of phosphinohydrazines (Ar–NH–NH–PR2) 2,5-dialkyl-1,4-benzoquinones. underwent 1,3-dipolar cycloaddition with cyclooctyne dimethylacetylene dicarboxylate to give N-heterocyclic iminophosphoranes (NHIPs), which are structurally similar cyclic (alkyl)(amino)carbenes. The reaction is compatible various phosphorus atom substituents including phenyl...

Photoresponsive systems for site-selective RNA scission have been prepared by combining Lu(III) ions with acridine/azobenzene dual-modified DNA. The modified DNA forms a heteroduplex substrate RNA, and the target phosphodiester linkages in front of acridine residue is selectively activated so that ion rapidly cleaves linkage. Azobenzene introduced adjacent to acts as photoresponsive switch, which triggers upon UV irradiation. A trans isomer azobenzene efficiently suppresses scission, whereas...

Remote C-H functionalization of heterocyclic biaryls will be great importance in synthesis and medicinal chemistry. Through adjusting the geometric relationship directing atom target bonds, two new catalytic templates have been developed to enable more hindered ortho-C-H bonds heterobiaryls bearing heteroatom at meta- or para-positions, affording unprecedented site-selectivity. The use template chaperone also overcomes product inhibition renders catalytic. utility this protocol was...

Abstract The fluorination is performed on α‐amino acid derivatives carrying a broad range of β‐substituents such as aryl, hetaryl, alkyl, and alkynyl groups endowed with various functional groups.

The structures of ammonium manganese(II) dialuminium tris(phosphate) dihydrate, (NH 4 )MnAl 2 (PO ) 3 ·2H O, and nickel(II) )NiAl were determined using single-crystal diffraction data. title compounds are isotypic to cobalt aluminophosphate, )CoAl O (LMU-3) [Panz et al. (1998). Inorg. Chim. Acta , 269 73–82], in which a three-dimensional network vertex-sharing AlO 5 PO moieties delineate twelve-membered channels ammonium, NH + transition-metal cations ( M = Mn 2+ Ni reside as charge...

Abstract Remote C−H functionalization of heterocyclic biaryls will be great importance in synthesis and medicinal chemistry. Through adjusting the geometric relationship directing atom target bonds, two new catalytic templates have been developed to enable more hindered ortho ‐C−H bonds heterobiaryls bearing heteroatom at meta ‐ or para ‐positions, affording unprecedented site‐selectivity. The use template chaperone also overcomes product inhibition renders catalytic. utility this protocol...

Site-selective functionalizations of C–H bonds will ultimately afford chemists transformative tools for editing and constructing complex molecular architectures 1-4 . Towards this goal, developing strategies to activate that are distal from a functional group is essential 4-6 In context, distinguishing remote on adjacent carbon atoms an extraordinary challenge due the lack electronic or steric bias between two positions. Herein, we report design catalytic system leveraging directing template...

<p>Site-selective functionalizations of C–H bonds will ultimately afford chemists transformative tools for editing and constructing complex molecular architectures<sup>1-4</sup>. Towards this goal, developing strategies to activate that are distal from a functional group is essential<sup>4-6</sup>. In context, distinguishing remote on adjacent carbon atoms an extraordinary challenge due the lack electronic or steric bias between two positions. Herein, we report...

Through consecutive selective C–H functionalization at multiple sites, the direct molecular editing of heteroarene carbon-hydrogen (C–H) bonds has potential to grant rapid access into diverse space; a valuable but often challenging venture achieve in medicinal chemistry. Contrasting with electronically-biased heterocyclic bonds, remote benzocyclic on bicyclic aza-arenes are especially difficult differentiate due lack intrinsic steric/electronic biases. careful consideration distance and...

Through consecutive selective C–H functionalization at multiple sites, the direct molecular editing of heteroarene carbon-hydrogen (C–H) bonds has potential to grant rapid access into diverse space; a valuable but often challenging venture achieve in medicinal chemistry. Contrasting with electronically-biased heterocyclic bonds, remote benzocyclic on bicyclic aza-arenes are especially difficult differentiate due lack intrinsic steric/electronic biases. careful consideration distance and...