A5023708099- Genetics, Aging, and Longevity in Model Organisms
- Genetics and Neurodevelopmental Disorders
- Ubiquitin and proteasome pathways
- Circadian rhythm and melatonin
- Endoplasmic Reticulum Stress and Disease
- Genomics, phytochemicals, and oxidative stress
Inserm
2025
Université Côte d'Azur
2025
Centre d’Immunologie de Marseille-Luminy
2021
Centre Méditerranéen de Médecine Moléculaire
2021
Transcription factor EB (TFEB) is a key transcription that orchestrates the cellular response to stress. Dysregulation of TFEB associated with range human diseases, and understanding regulatory mechanisms crucial for identifying potential drug targets. In this study, we used Caenorhabditis elegans screen E3 ubiquitin ligases regulating activity TFEB's homolog, HLH-30, upon pathogenic infection. We identified WWP-1 as regulator HLH-30-dependent immune controlling HLH-30 stability mediate host...