A5090024930- Heat shock proteins research
- Enzyme Structure and Function
- Alzheimer's disease research and treatments
- Machine Learning in Bioinformatics
- RNA Interference and Gene Delivery
- Computational Drug Discovery Methods
- Immune Response and Inflammation
- Proteins in Food Systems
- Glycosylation and Glycoproteins Research
- Pesticide Exposure and Toxicity
- Pesticide Residue Analysis and Safety
- Toxin Mechanisms and Immunotoxins
- Polysaccharides and Plant Cell Walls
- Pesticide and Herbicide Environmental Studies
- Digestive system and related health
- Infant Nutrition and Health
- Mass Spectrometry Techniques and Applications
- ATP Synthase and ATPases Research
- Protein Structure and Dynamics
- Polysaccharides Composition and Applications
- Cell death mechanisms and regulation
- thermodynamics and calorimetric analyses
- Immune Cell Function and Interaction
Délégation Bretagne et Pays de la Loire
2024
Université de Rennes
2013-2018
Centre National de la Recherche Scientifique
2013-2018
Oncogenesis Stress Signaling
2016-2017
Centre Eugène Marquis
2017
Inserm
2016
Institut de génétique et de développement de Rennes
2016
Laboratoire de Biophotonique et Pharmacologie
2014
Institut de Recherche en Santé, Environnement et Travail
2014
Amyloidosis is a group of proteinopathies characterized by the systemic or organ-specific deposition proteins in form amyloid fibers. Nearly 40 play role these pathologies, and structures associated fibers are beginning to be determined Cryo-EM. However, molecular events underlying process, such as fiber nucleation elongation, poorly understood, which impairs developing efficient therapies. In most cases, only few dozen amino acids pathological protein found final structure fibers, while...
Metalloprotease-processed CD95L (cl-CD95L) is a soluble cytokine that implements PI3K/Ca2+ signaling pathway in triple-negative breast cancer (TNBC) cells. Accordingly, high levels of cl-CD95L TNBC women correlate with poor prognosis, and administration this ligand an orthotopic xenograft mouse model accelerates the metastatic dissemination The molecular mechanism underlying CD95-mediated cell migration remains unknown. Here, we present genetic pharmacologic evidence anti-apoptotic molecules...
Since noncovalent protein macrocomplexes are implicated in many cellular functions, their characterization is essential to understand how they drive several biological processes. Over the past 20 years, because of its high sensitivity, mass spectrometry has been described as a powerful tool for both identification and understanding organization. Nonetheless, stabilizing these macrocomplexes, by introducing covalent bonds, prerequisite before analysis denaturing technique. In this study,...
The 90-kDa heat shock protein (Hsp90) is a highly flexible dimer able to self-associate in the presence of divalent cations or under shock. This study investigated relationship between Hsp90 oligomers and cochaperone Aha1 (activator ATPase). interactions with dimers were evaluated by ultracentrifugation, size-exclusion chromatography coupled multiangle laser light scattering high-mass matrix-assisted desorption/ionization time-of-flight mass spectrometry. was bind up four molecules, are also...
Proposed models of the function Hsp90 are characterised by high flexibility dimeric state and conformational changes regulated both nucleotide binding hydrolysis, co-chaperone interactions. In addition to its state, self-associates upon particular stimuli. The dimer is building block up hexamer that we named “cosy nest”, dodecamer results from association two hexamers. Oligomers exhibit chaperone activity, but their exact mechanism action has not yet been determined. One best ways elucidate...
Abstract Amyloidosis are proteinopathies characterized by systemic or organ-specific deposition of proteins in the form amyloid fibers. Nearly forty have been identified to play a role these pathologies and structures associated fibers beginning be determined Cryo-EM. However, molecular events underlying process, such as fiber nucleation elongation, poorly understood, which impairs developing efficient therapies. In most cases, only few dozen amino acids pathological protein found final...