A5057464112- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Herpesvirus Infections and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
- T-cell and Retrovirus Studies
- Zoonotic diseases and public health
- Microbial infections and disease research
- Prion Diseases and Protein Misfolding
- Immunotherapy and Immune Responses
- Escherichia coli research studies
- Protein purification and stability
- Dendrimers and Hyperbranched Polymers
- Clostridium difficile and Clostridium perfringens research
- Plant and Fungal Interactions Research
- Animal health and immunology
- Genomic variations and chromosomal abnormalities
- Survey Sampling and Estimation Techniques
- T-cell and B-cell Immunology
- Virology and Viral Diseases
- Vector-borne infectious diseases
Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
2009-2024
CEA Paris-Saclay
2019-2020
Université Bretagne Loire
2017
Université Européenne de Bretagne
2013
Friedrich-Loeffler-Institut
2011
University of Veterinary Medicine Hannover, Foundation
2011
Veterinary and Agrochemical Research Centre
2011
African swine fever (ASF) is an acute haemorrhagic disease of domestic pigs for which there currently no vaccine. We showed that experimental immunisation with the non-virulent OURT88/3 genotype I isolate from Portugal followed by closely related virulent OURT88/1 could confer protection against challenge isolates Africa including Benin 97/1 and X Uganda 1965 isolate. This strategy protected most challenged either or both viraemia. Cross-protection was correlated ability different ASFV to...
Wildlife species as reservoirs of infectious pathogens represent a serious constraint in the implementation disease management strategies. In Mediterranean island Corsica, dynamics hepatitis E virus (HEV) and Aujeszky's (ADV) are suspected to be influenced by interactions between wild domestic pigs. To improve our understanding these influences, we first compared seroprevalences both viruses pig populations from different locations with contrasted levels wild-domestic interactions, ADV...
Porcine reproductive and respiratory syndrome virus (PRRSV) replicates primarily in pulmonary alveolar macrophages (PAMs) the resulting lung damage is influenced by strain virulence. To better understand pathogenesis of PRRSV infection, we performed a longitudinal study PAM population cytokines specific pathogen-free pigs infected either with highly pathogenic Lena or low Finistere comparison to uninfected pigs. Bronchoalveolar lavage fluid (BALF) blood were collected follow viral, cellular...
African swine fever (ASF) is a lethal hemorrhagic disease in domestic pigs and wild suids caused by virus (ASFV), which threatens the industry globally. In its native enzootic foci, ASFV naturally circulating between soft ticks of genus Ornithodoros, especially O. moubata group, reservoir suids, such as warthogs (Phacochoerus spp.) that are bitten infected inhabiting their burrows. While ability some Afrotropical to transmit maintain well established, vector status Palearctic tick species...
Abstract The time-dependent transmission rate of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) the correlation between infectiousness, virological parameters antibody responses infected pigs were studied in experimental conditions. Seven successive trials involving a total 77 specific pathogen-free piglets carried out from 7 to 63 days post-inoculation (dpi). A semi-quantitative real time RT-PCR was developed assess evolution viral genome load blood nasal swabs inoculated...
Abstract The conventional C-strain vaccine induces early protection against classical swine fever (CSF), but infected animals cannot be distinguished from vaccinated animals. CP7_E2alf marker vaccine, a pestivirus chimera, could suitable substitute for to control CSF outbreaks. In this study, single oral applications of and vaccines were compared their efficacy induce virus (CSFV) challenge with the moderately virulent Bas-Rhin isolate, in pigs as two days post-immunization. This work...
Abstract Background Several species of soft ticks in genus Ornithodoros are known vectors and reservoirs African swine fever virus (ASFV). However, the underlying mechanisms vector competence for ASFV across remain to be fully understood. To that end, this study compared replication dissemination as well vertical transmission descendants between moubata , O . erraticus verrucosus relation what is about ability these tick transmit pigs. mimic natural situation, a more realistic model was used...
African swine fever virus represents a significant reemerging threat to livestock populations, as its incidence and geographic distribution have surged over the past decade in Europe, Asia, Caribbean, resulting substantial socio-economic burdens adverse effects on animal health welfare. In previous report, we described protective properties of our newly thermo-attenuated strain (ASFV-989) pigs against an experimental infection parental Georgia 2007/1 virulent strain. this new study,...
Abstract Most of the microorganisms living in a symbiotic relationship different animal body sites (microbiota) reside gastrointestinal tract (GIT). Several studies have shown that microbiota is involved host susceptibilities to pathogens. The fecal domestic and wild suids was analyzed. Bacterial communities were determined from feces obtained pigs ( Sus scrofa ) raised under conditions: specific-pathogen-free (SPF) same bred, indigenous backyard farm Kenya. Secondly, composition African...
Classical swine fever (CSF) severity is dependent on the virulence of CSF virus (CSFV) strain.The earliest event detected following CSFV infection a decrease in lymphocytes number.With some strains this leads to lymphopenia, varying according strain virulence.This lymphocyte depletion attributed an induction apoptosis non-infected bystander cells.We collected peripheral blood mononuclear cells (PBMC) before and during 3 days post-infection with either highly or moderately virulent subjected...
The understanding of host-parasite systems in wildlife is increasing interest relation to the risk emerging diseases livestock and humans. In this respect, many efforts have been dedicated controlling classical swine fever (CSF) European Wild Boar. But CSF eradication has not always achieved even though vaccination implemented at a large-scale. Piglets assumed be main cause persistence wild since they appeared more often infected less immune than older animals. However, assumption emerged...
African swine fever is a haemorrhagic disease in pig production that can have disastrous financial consequences for farming. No vaccines are currently available and animal slaughtering or area zoning to restrict risk-related movements the only effective measures prevent spread of disease. Ornithodoros soft ticks known transmit virus (ASFV) pigs farms, following natural epidemiologic cycle virus. Tick saliva has been shown modulate host physiological immunological responses during feeding on...