A5067614600- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Animal Virus Infections Studies
- Microbial infections and disease research
- Freezing and Crystallization Processes
- Vector-Borne Animal Diseases
- Effects of Environmental Stressors on Livestock
- Viral Infections and Immunology Research
- Virus-based gene therapy research
- T-cell and B-cell Immunology
- Microbial Metabolic Engineering and Bioproduction
- Plant Virus Research Studies
- Immunotherapy and Immune Responses
- Climate change and permafrost
- Soil Carbon and Nitrogen Dynamics
- Virology and Viral Diseases
- Viral Infections and Outbreaks Research
- Veterinary medicine and infectious diseases
- Fungal Biology and Applications
- Biocrusts and Microbial Ecology
- Indigenous Studies and Ecology
- Toxin Mechanisms and Immunotoxins
- Marine and environmental studies
Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
2016-2025
Département Santé Animale
2024
Virologie et Immunologie Moléculaires
2016-2023
CEA Paris-Saclay
2022-2023
Université Bretagne Loire
2016-2018
Université Européenne de Bretagne
2013
Moscow State University
1977
A transmission experiment involving 5-week-old specific-pathogen-free (SPF) piglets, with (MDA+) or without maternally-derived antibodies (MDA−), was carried out to evaluate the impact of passive immunity on a swine influenza virus (swIAV). In each group (MDA+/MDA−), 2 seeders were placed 4 piglets in direct contact and 5 indirect (3 replicates per group). Serological kinetics (ELISA) individual viral shedding (RT-PCR) monitored for 28 days after infection. MDA waning estimated using...
<title>Abstract</title> Farmed pigs are frequently exposed to respiratory infections, with swine influenza A virus (swIAV) and porcine reproductive syndrome (PRRSV) being key drivers. Most co-infection studies these viruses have focused on PRRSV infection followed by swIAV. However, the reverse scenario, where swIAV is given first then PRRSV, has not been explored. This sequence plausible under natural conditions warrants further study, especially that shown in mice impair alveolar...
<title>Abstract</title> Background Swine influenza A viruses (swIAV) are highly contagious zoonotic pathogens that cause an acute respiratory infection in pigs, presenting substantial economic and health risks. This drives the pig industry stakeholders animal to monitor swIAV livestock. Prior 2009 flu pandemic, H1<sub>av</sub>N1 (HA-1C.2.1) H1<sub>hu</sub>N2 (HA-1B.1.2.3) circulated herds France. The H1N1<sub>pdm</sub> (HA-1A.2.3.3) lineage became enzootic after its introduction. In 2020, a...
Abstract In 2018, a veterinarian became sick shortly after swabbing sows exhibiting respiratory syndrome on farm in France. Epidemiologic data and genetic analyses revealed consecutive human-to-swine swine-to-human influenza A(H1N1)pdm09 virus transmission, which occurred despite some biosecurity measures. Providing pig industry workers the annual vaccine might reduce transmission risk.
Pigs are a “mixing vessel” for influenza A viruses (IAVs) because of their ability to be infected by avian and human IAVs propensity facilitate viral genomic reassortment events. Also, as may evolve differently in swine humans, pigs can become reservoir old strains against which the population has immunologically naive. Thus, from novel swine-specific H1N1pdm genogroup continue diverge seasonal and/or other infecting lead emergence that would not covered vaccines based on antigens closely...
In autumn/winter 2016–2017, HPAI-H5N8 viruses belonging to the A/goose/Guandong/1/1996 (Gs/Gd) lineage, clade 2.3.4.4b, were responsible for outbreaks in domestic poultry Europe, and veterinarians requested reinforce surveillance of pigs bred HPAI-H5Nx confirmed mixed herds. this context, ten pig herds visited southwestern France from December 2016 May 2017 serological analyses influenza A virus (IAV) infections carried out by ELISA hemagglutination inhibition assays. one herd, backyard was...
Abstract In 2020, a new genotype of swine H1N2 influenza virus (H1 av N2–HA 1C.2.4) was identified in France. It rapidly spread within the pig population and supplanted previously predominant H1 N1-HA 1C.2.1 virus. To characterize this which is genetically antigenically distant from other Nx viruses detected France, an experimental study conducted to compare outcomes N2 N1 infections pigs evaluate protection conferred by only inactivated vaccine currently licensed Europe containing HA 1C...
This report describes the detection of a triple reassortant swine influenza A virus H1avN2 subtype. It evolved from an avian-like H1avN1 that first acquired N2 segment seasonal H3N2, then M 2009 pandemic H1N1, in two reassortments estimated to have occurred 10 years apart. study illustrates how recurrent infections increase co-infection risk and facilitate evolutionary jumps by successive gene exchanges. recalls importance appropriate biosecurity measures inside holdings limit persistence...
In order to assess influenza D virus (IDV) infections in swine France, reference reagents were produced specific pathogen free pigs ensure serological and virological analyses. Hemagglutination inhibition (HI) assays carried out on 2090 domestic pig sera collected 2012–2018 102 farms. Only 31 from breeding sows sampled 2014–2015 six farrow-to-finish herds with respiratory disorders contained IDV-specific antibodies. two of them, within-herd percentage positive samples (73.3% 13.3%,...
Influenza D virus was isolated from pigs on a mixed pig and beef farm in France. Investigation suggested bull-to-pig transmission spread among pigs. The swine influenza recovered reassortant of D/660 D/OK lineages. Reported mutations the receptor binding site might be related to host adaptation.
Swine influenza is a respiratory infection of pigs that may have significant economic impact in affected herds and pose threat to the human population since swine A viruses (swIAVs) are zoonotic pathogens. Due increasing genetic diversity swIAVs because novel reassortants or variants become enzootic implications, surveillance strongly encouraged. Therefore, diagnostic tests advanced technologies able identify circulating strains rapidly critically important. Several reverse transcription...
In pigs, influenza A viruses and Mycoplasma hyopneumoniae (Mhp) are major contributors to the porcine respiratory disease complex. Pre-infection with Mhp was previously shown experimentally exacerbate clinical outcomes of H1N1 infection during first week after virus inoculation. order better understand interactions between these pathogens, we aimed assess very early responses (at 5, 24 48 h) in pigs pre-infected or not Mhp. Clinical signs macroscopic lung lesions were similar both infected...
Swine influenza A virus (swIAV) is a major pathogen affecting pigs with huge economic impact and potentially zoonotic. Epidemiological studies in endemically infected farms permitted to identify critical factors favoring on-farm persistence, among which maternally-derived antibodies (MDAs). Vaccination commonly practiced breeding herds might be used for immunization of growing at weaning. Althoughinterference between MDAs vaccination was reported young piglets, its on swIAV transmission not...
The surveillance of swine influenza A viruses in France revealed the emergence an antigenic variant following deletions and mutations that are fixed HA-encoding gene European human-like reassortant H1N2 lineage. In this study, we compared outcomes parental (H1
This study evaluated the genetic and antigenic evolution of swine influenza A viruses (swIAV) two main enzootic H1 lineages, i.e., HA-1C (H1av) -1B (H1hu), circulating in France between 2000 2018. SwIAV RNAs extracted from 1220 nasal swabs were hemagglutinin/neuraminidase (HA/NA) subtyped by RT-qPCRs, 293 virus isolates sequenced. In addition, 146 H1avNy 105 H1huNy strains submitted to hemagglutination inhibition tests. H1avN1 (66.5%) H1huN2 (25.4%) subtypes predominant. Most belonged...
Swine influenza A viruses (swIAVs) are a major cause of respiratory disease in pigs worldwide, presenting significant economic and health risks. These can reassort, creating new strains with varying pathogenicity cross-species transmissibility. This study aimed to monitor the genetic antigenic evolution swIAV France from 2019 2022. Molecular subtyping revealed marked increase H1avN2 cases 2020 onwards, altering previously stable subtypes' distribution. Whole-genome sequencing phylogenetic...
During 2009, pandemic influenza A(H1N1)pdm09 virus affected humans on Réunion Island. Since then, the has sustained circulation among local swine herds, raising concerns about potential for genetic evolution of and possible retransmission back to variants with increased virulence. Continuous surveillance infection in pigs is recommended.