A5046191011- Viral Infections and Vectors
- Influenza Virus Research Studies
- Vector-borne infectious diseases
- Virology and Viral Diseases
- Mosquito-borne diseases and control
- Viral gastroenteritis research and epidemiology
- Viral Infections and Outbreaks Research
- Hepatitis Viruses Studies and Epidemiology
- Respiratory viral infections research
- Research on Leishmaniasis Studies
- Zoonotic diseases and public health
- Rabies epidemiology and control
- Animal Virus Infections Studies
- Vector-Borne Animal Diseases
- Vibrio bacteria research studies
- Animal Disease Management and Epidemiology
- T-cell and B-cell Immunology
- Fire effects on ecosystems
- Trypanosoma species research and implications
- Liver Disease and Transplantation
- SARS-CoV-2 and COVID-19 Research
- Insect symbiosis and bacterial influences
- Plant and Fungal Interactions Research
- Immunotherapy and Immune Responses
- Bird parasitology and diseases
Centre National de la Recherche Scientifique
2015-2020
Institut de Recherche pour le Développement
2011-2020
Processus Infectieux en Milieu Insulaire Tropical
2015-2020
Inserm
2015-2020
Peuplements végétaux et bioagresseurs en milieu tropical
2015-2019
Centre de Recherche et de Veille sur les Maladies Emergentes dans l’Océan Indien
2012-2017
Écologie Marine Tropicale des Océans Pacifique et Indien
2011-2015
Institut de Recherche pour le Développement
2015
Institut de Recherche pour le Développement
2014
University of French Guiana
2003-2005
Hepatitis E virus (HEV) causes an orofecal disease transmitted through poor hygiene environments, contaminated food (mainly pork products), or by contacts with infected animals. Very little data are currently available regarding the in Southwestern Indian Ocean Islands. We report first sero- and viro-survey for HEV human swine Madagascar. A seroprevalence rate of 14.1% (60 427) was measured slaughterhouse workers. Seroprevalence to pigs estimated 71.2% (178 250), strongly suggesting...
The Paramyxoviridae form an increasingly diverse viral family, infecting a wide variety of different hosts. In recent years, they have been linked to disease emergence in many animal populations and humans. Bats rodents identified as major capable harboring paramyxoviruses, host shifting between these animals is likely be important driving factor the underlying evolutionary processes that eventually lead emergence. Here, we studied paramyxovirus circulation within endemic introduced wild...
ABSTRACT Buruli disease, caused by Mycobacterium ulcerans , is the third most important mycobacterial disease in humans besides tuberculosis and leprosy. We have compared systemic intralesional cytokine production patients presenting with a nodular form necrotizing, ulcerative of disease. Gamma interferon (IFN-γ) levels response to whole M. bovis BCG bacilli purified Ag85 protein from were lower peripheral blood mononuclear cells (PBMC) cultures than PBMC healthy derivative-positive...
Background To date, there is little information that reflects the true extent of spread pH1N1/2009v influenza pandemic at community level as infection often results in mild or no clinical symptoms. This study aimed assessing through a prospective study, attack rate pH1N1/2009 virus Reunion Island and risk factors infection, during 2009 season. Methodology/Principal Findings A serosurvey was conducted austral winter, frame population study. Pairs sera were collected from 1687 individuals...
ABSTRACT Seabird ticks are known reservoirs of bacterial pathogens medical importance; however, parasitizing tropical seabirds have received less attention than their counterparts from temperate and subpolar regions. Recently, Rickettsia africae was described to infect seabird the western Indian Ocean New Caledonia, constituting only available data on associated with tick species. Here, we combined a pyrosequencing-based approach classical molecular analysis targeting bacteria potential...
Objective The aim of the present study was to weigh up, at community level, respective roles played by pandemic Influenza (pH1N1) virus and co-circulating human Non-Influenza Respiratory Viruses (NIRVs) during first wave 2009 pH1N1 pandemic. Methods A population-based prospective cohort conducted in Reunion Island austral winter (weeks 30–44) that allowed identification 125 households with least one member who developed symptoms Influenza-like illness (ILI). Three consecutive nasal swabs...
Abstract We found a diversity of Rickettsia spp. in seabird ticks from 6 tropical islands. The bacteria showed strong host specificity and sequence similarity with strains other regions. Seabird may be key reservoirs for pathogenic spp., bird hosts have role dispersing tick-associated infectious agents over large distances.
Background Metagenomic analyses have been widely used in the last decade to describe viral communities various environments or identify etiology of human, animal, and plant pathologies. Here, we present a simple standardized protocol that allows for purification sequencing RNA viromes from complex biological samples with an important reduction host DNA contaminants, while preserving infectivity particles. Principal Findings We evaluated different steps, random reverse transcriptions...
Ducks and seabirds are natural hosts for influenza A viruses (IAV). On oceanic islands, the ecology of IAV could be affected by relative diversity, abundance density ducks. Seabirds most abundant widespread avifauna in Western Indian Ocean and, this region, islands represent major breeding sites a large diversity potential host species. Based on serological assays, we assessed range virus subtype terns Ocean. We further investigated spatial variation transmission patterns between identified...
An eco-epidemiological investigation was carried out on Madagascar bat communities to better understand the evolutionary mechanisms and environmental factors that affect virus transmission among species in closely related members of genus Morbillivirus, currently referred as Unclassified Morbilli-related paramyxoviruses (UMRVs). A total 947 bats were investigated originating from 52 capture sites (22 caves, 18 buildings, 12 outdoor sites) distributed over different bioclimatic zones island....
We provide serological evidence of lyssavirus circulation among bats on southwestern Indian Ocean (SWIO) islands. A total 572 belonging to 22 species were collected Anjouan, Mayotte, La Réunion, Mauritius, Mahé and Madagascar screened by the Rapid Fluorescent Focus Inhibition Test for presence neutralising antibodies against two main rabies related lyssaviruses circulating African continent: Duvenhage (DUVV) Lagos bat (LBV), representing phylogroups I II, respectively. 97 42 sera able...
Reunion Island is currently experiencing an epidemic caused by Dengue virus type-2 (DENV-2) resulting in over 6,763 cases from austral summer 2017 to winter 2018. Phylogenetic analyses on two non-imported of dengue infection highlight a regional circulation DENV-2 Cosmopolitan lineage 1 both and the Seychelles.
Intralesional Th2 responses preceded the development of Th1 in localized cutaneous leishmaniasis due to Leishmania guyanensis. Although number parasites increased lesions, no correlation was found between levels cytokine expression and parasites. In contrast, decreased lesions is negatively correlated gamma interferon expression.
ABSTRACT Transforming growth factor β (TGF-β) has been shown to be a central immunomodulator used by leishmaniae escape effective mechanisms of protection in human and murine infections with these parasites. However, all the information is derived from studies established infection, while little known about TGF-β production response Leishmania stimulation healthy subjects. In this study, TGF-β1 was demonstrated peripheral blood mononuclear cells subjects never exposed live guyanensis ,...
Major explosive outbreaks of Rift Valley fever (RVF), an arthropod borne zoonotic disease, occur in humans and animals with significant mortality economic impact across continental Africa the Indian Ocean region (Madagascar, Comoros archipelago). Recently, sporadic human cases have been reported Mayotte Grande Comore, two islands belonging to archipelago. To identify hypothetical source virus introduction inter-epidemic or a post-epidemic period, longitudinal survey livestock was set up...
During 2009, pandemic influenza A(H1N1)pdm09 virus affected humans on Réunion Island. Since then, the has sustained circulation among local swine herds, raising concerns about potential for genetic evolution of and possible retransmission back to variants with increased virulence. Continuous surveillance infection in pigs is recommended.
Background/Objectives Molecular epidemiology is a powerful tool to decipher the dynamics of viral transmission, quasispecies temporal evolution and origins. Little known about pH1N1 molecular in general population. A prospective study (CoPanFlu-RUN) was carried out Reunion Island characterize genetic variability occurring population during Influenza pandemic 2009. Methodology We directly amplified genomes from 28 different nasal swabs (26 individuals 21 households). Fifteen strains were...
Abstract One portion of the family Paramyxoviridae is a group Unclassified Morbilli - Related Viruses ( UMRV ) recently recognized in wild small mammals. At global level, evolutionary history these viruses not properly understood and relationships between their hosts still remain largely unstudied. The present study revealed, for first time, that Rodentia associated emerged from common ancestor southern Africa more than 4000 years ago. Sequenced originating different regions world, clustered...