Heme oxygenase-1 (HO-1), a rate-limiting enzyme involved in the degradation of heme, is induced response to wide range stress conditions. HO-1 exerts antiviral activity against broad viruses, including Hepatitis C virus, human immunodeficiency and dengue virus by inhibiting viral growth. It has been reported that displays Zika (ZIKV) but mechanisms inhibition remain largely unknown. Using ZIKV RNA replicon with Green Fluorescent Protein (GFP) as reporter protein, we were able show expression...

Mosquito-borne Zika virus (ZIKV) recently emerged in South Pacific islands and Americas where large epidemics were documented. In the present study, we investigated contribution of structural proteins C, prM E permissiveness human host cells to epidemic strains ZIKV. To this end, evaluated capacity strain BeH819015 infect epithelial A549 neuronal SH-SY5Y comparison African historical MR766 strain. For that purpose, generated a molecular clone chimeric which contains protein region. We showed...

Zika virus (ZIKV) is an emerging mosquito-borne flavivirus considered as a threat to human health due large epidemics and serious clinical outcomes such microcephaly in new-borns. Like all flaviviruses, ZIKV relies on the cellular machinery complete its viral cycle, with endoplasmic reticulum (ER) being critical site of replication factories. The sudden high protein load ER induces stress which cell responds appropriate unfolded response (UPR) attempt restore disturbed homeostasis. When...

Reunion Island is currently experiencing an epidemic caused by Dengue virus type-2 (DENV-2) resulting in over 6,763 cases from austral summer 2017 to winter 2018. Phylogenetic analyses on two non-imported of dengue infection highlight a regional circulation DENV-2 Cosmopolitan lineage 1 both and the Seychelles.

Zika virus (ZIKV) is an emerging human mosquito-transmitted pathogen of global concern, known to be associated with complications such as congenital defects and neurological disorders in adults. ZIKV infection induction cell death. However, previous studies suggest that the virally induced apoptosis occurs at a slower rate compared course viral production. In this present study, we investigated capacity delay host apoptosis. We provide evidence has ability interfere whether it intrinsically...

Zika virus (ZIKV) is an emerging human mosquito-transmitted pathogen of global concern, known to be associated with complications such as congenital defects and neurological disorders in adults. ZIKV infection induction cell death. However, previous studies suggest that the virally-induced apoptosis occurs at a slower rate compared course viral production. In this present study, we investigated capacity delay host apoptosis. We provide evidence has ability interfere whether it intrinsically...

Island communities are interesting study sites for microbial evolution during epidemics, as their insular nature reduces the complexity of population's connectivity. This was particularly true on Reunion first half 2021, when international travel restricted in order to mitigate risk SARS-CoV-2 introductions. Concurrently, Beta variant became dominant and started circulate at high levels several months before being completely replaced by Delta October 2021. Here, we explore some...

The neurological complications of infection by the mosquito-borne Zika virus (ZIKV) include Guillain–Barré syndrome (GBS), an acute inflammatory demyelinating polyneuritis. GBS was first associated with recent ZIKV epidemics caused emergence Asian lineage in South Pacific. Here, we hypothesize that ZIKV-associated relates to a molecular mimicry between viral envelope E (E) protein and neural proteins involved GBS. analysis epidemic strains showed glycan loop (GL) region includes IVNDT motif...

Flaviviruses replicate in membrane factories associated with the endoplasmic reticulum (ER). Significant levels of flavivirus viral protein accumulation contribute to ER stress. As a consequence, host cell exhibits an Unfolded Protein Response (UPR), subsequently stimulating appropriate cellular responses such as adaptation, autophagy or apoptosis. The correct redox conditions this compartment are essential forming native disulfide bonds proteins. Zika virus (ZIKV) has ability induce...

Flaviviruses replicate in membranous factories associated with the endoplasmic reticulum (ER). The replication rate generates a high polyprotein integration that can contribute to ER stress. Therefore, host cell develop an Unfolded Protein Response (UPR) this protein accumulation which will stimulate appropriate cellular responses infectious context (Adaptation, autophagy or death). These different stress help overcome virus and usually support antiviral strategies initiated by infected...

Zika Virus (ZIKV) is a pathogenic member of the flavivirus family, with several unique charac-teristics. Unlike any other arbovirus, ZIKV can be transmitted sexually and maternally, thus produce congenital syndromes (CZS) due to its neurotropism. This challenges search for safe active molecules that protect pregnant women their fetuses. In this context, in ab-sence existing treatment, it seemed worthwhile test whether known cytoprotective properties adiponectin pharmacological analog,...

Zika virus (ZIKV) is a pathogenic member of the flavivirus family, with several unique characteristics. Unlike any other arbovirus, ZIKV can be transmitted sexually and maternally, thus produce congenital syndromes (CZS) due to its neurotropism. This challenges search for safe active molecules that protect pregnant women their fetuses. In this context, in absence existing treatment, it seemed worthwhile test whether known cytoprotective properties adiponectin pharmacological analog,...

Cell death by apoptosis is a major cellular response, in the control of tissue homeostasis and as defense mechanism case aggression like an infection. self-destruction part antiviral responses, aimed at limiting spread virus. Although it may contribute to deleterious effects infectious pathology, remains key for viral clearance resolution The mechanisms cell processes viruses have been extensively studied. Apoptosis can be triggered different determinants, through pathways, result virally...

Flaviviruses replicate in membranous factories associated with the endoplasmic reticulum (ER). Significant levels of flavivirus polyprotein integration contribute to ER stress and host cell may exhibit an Unfolded Protein Response (UPR) this protein accumulation, stimulating appropriate cellular responses such as adaptation, autophagy or death. These different support other antiviral strategies initiated by infected cells can help overcome viral infection. In epithelial A549 cells, a model...

Flaviviruses replicate in membrane factories associated with the endoplasmic reticulum (ER). Significant levels of flavivirus viral protein accumulation contribute to ER stress. As a consequence, host cell exhibits an Unfolded Protein Response (UPR), subsequently stimulating appropriate cellular responses such as adaptation, autophagy or apoptosis. The correct redox conditions this compartment are essential form native disulfide bonds proteins. ZIKA virus (ZIKV) has ability induce persistent...

Zika virus (ZIKV) is an emerging human mosquito-transmitted pathogen of global concern, known to cause severe complications such as congenital defects and neurological disorders in adults. ZIKV infection associated with cell death. However, previous studies suggest that the virally-induced apoptosis occurs at a slower rate compared course viral production. In this present study, we investigated capacity delay host apoptosis. We provide evidence has ability control programmed death whether it...

Neurological complications of infection by the mosquito-borne Zika virus (ZIKV) include Guillain-Barré syndrome (GBS), an acute inflammatory demyelinating polyneuritis. GBS was first associated with recent ZIKV epidemics caused emergence Asian lineage in South Pacific. Here, we hypothesize that ZIKV-associated relates to a molecular mimicry between viral envelope E (E) protein and neural proteins involved GBS. Analysis epidemic strains showed glycan loop (GL) region includes IVNDT...