A5039184682- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Microbial infections and disease research
- Virus-based gene therapy research
- Seaweed-derived Bioactive Compounds
- Marine and coastal plant biology
- Viral Infections and Immunology Research
- Antifungal resistance and susceptibility
- Multiferroics and related materials
- Immunotherapy and Immune Responses
- Vector-Borne Animal Diseases
- Zoonotic diseases and public health
- Organophosphorus compounds synthesis
- HIV Research and Treatment
- Bioactive Compounds and Antitumor Agents
- Essential Oils and Antimicrobial Activity
- Metabolomics and Mass Spectrometry Studies
- SARS-CoV-2 and COVID-19 Research
- Cytomegalovirus and herpesvirus research
- Bacteriophages and microbial interactions
- Effects of Environmental Stressors on Livestock
- Algal biology and biofuel production
Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
2016-2025
Université de Bretagne Occidentale
2010-2025
Environnement, ville, société
2024
Laboratoire Structure et Dynamique par Résonance Magnétique
2015-2024
CEA Paris-Saclay
2022-2024
Virologie et Immunologie Moléculaires
2016-2024
Département Santé Animale
2024
Laboratoire des Sciences et Techniques de l’Information de la Communication et de la Connaissance
2023
Centre National de la Recherche Scientifique
2021
PROTEO
2018-2020
A fundamental goal in the biological sciences is definition of groups organisms based on evolutionary history and naming those groups. For influenza viruses (IAVs) swine, understanding hemagglutinin (HA) genetic lineage a circulating strain aids vaccine antigen selection allows for inferences about efficacy. Previous reporting H1 virus HA swine relied colloquial names, frequently with incriminating stigmatizing geographic toponyms, making comparisons between studies challenging. To overcome...
Swine influenza presents a substantial disease burden for pig populations worldwide and poses potential pandemic threat to humans. There is considerable diversity in both H1 H3 viruses circulating swine due the frequent introductions of from humans birds coupled with geographic segregation global populations. Much this characterized genetically but antigenic these poorly understood. Critically, shapes risk profile terms their epizootic potential. Here, using most comprehensive set virus data...
Water-soluble sulfated polysaccharides isolated from two red algae Sphaerococcus coronopifolius (Gigartinales, Sphaerococcaceae) and Boergeseniella thuyoides (Ceramiales, Rhodomelaceae) collected on the coast of Morocco inhibited in vitro replication Human Immunodeficiency Virus (HIV) at 12.5 µg/mL. In addition, were capable inhibiting Herpes simplex virus type 1 (HSV-1) Vero cells values EC50 4.1 17.2 µg/mL, respectively. The adsorption step HSV-1 to host cell seems be specific target for...
The declaration of the human influenza A pandemic (H1N1) 2009 (H1N1/09) raised important questions, including origin and host range [1], [2]. Two three pandemics in last century resulted spread virus to pigs (H1N1, 1918; H3N2, 1968) with subsequent independent establishment evolution within swine worldwide [3]. key public veterinary health consideration context evolving is whether H1N1/09 could become established pig populations [4]. We performed an infection transmission study...
ABSTRACT The emergence in humans of the A(H1N1)pdm09 influenza virus, a complex reassortant virus swine origin, highlighted importance worldwide surveillance swine. To date, large-scale studies have been reported for southern China and North America, but such data not yet described Europe. We report first genomic characterization 290 viruses collected from 14 European countries between 2009 2013. A total 23 distinct genotypes were identified, with 7 most common comprising 82% incidence....
Swine influenza causes concern for global veterinary and public health officials. In continuing two previous networks that initiated the surveillance of swine viruses (SIVs) circulating in European pigs between 2001 2008, a third Surveillance Network Influenza Pigs (ESNIP3, 2010–2013) aimed to expand widely knowledge epidemiology SIVs. ESNIP3 stimulated programs harmonized SIV countries supported coordination appropriate diagnostic tools subtyping methods. Thus, an extensive virological...
Concomitant infections by different influenza A virus subtypes within pig farms increase the risk of new reassortant emergence. The aims this study were to characterize epidemiology recurrent swine and identify their main determinants. follow-up was carried out in 3 selected known be affected repeated infections. Three batches pigs followed each farm from birth slaughter through a representative sample 40 piglets per batch. Piglets monitored individually on monthly basis for serology...
This study presents the results of virological surveillance for swine influenza viruses (SIVs) in Belgium, UK, Italy, France and Spain from 2006 to 2008. Our major aims were clarify occurrence three SIV subtypes - H1N1, H3N2 H1N2 at regional levels, identify novel reassortant antigenically compare SIVs with human H1N1 viruses. Lung tissue and/or nasal swabs outbreaks acute respiratory disease pigs investigated by virus isolation. The hemagglutinin (HA) neuraminidase (NA) determined using...
A transmission experiment involving 5-week-old specific-pathogen-free (SPF) piglets, with (MDA+) or without maternally-derived antibodies (MDA−), was carried out to evaluate the impact of passive immunity on a swine influenza virus (swIAV). In each group (MDA+/MDA−), 2 seeders were placed 4 piglets in direct contact and 5 indirect (3 replicates per group). Serological kinetics (ELISA) individual viral shedding (RT-PCR) monitored for 28 days after infection. MDA waning estimated using...
<title>Abstract</title> Farmed pigs are frequently exposed to respiratory infections, with swine influenza A virus (swIAV) and porcine reproductive syndrome (PRRSV) being key drivers. Most co-infection studies these viruses have focused on PRRSV infection followed by swIAV. However, the reverse scenario, where swIAV is given first then PRRSV, has not been explored. This sequence plausible under natural conditions warrants further study, especially that shown in mice impair alveolar...
Developing functional materials for optical remote control of magnetism can lead to faster, more efficient wireless data storage and sensing devices. In terms desired material properties, this development requires the combined optimization elastic interactions, low magnetic coercivity, a narrow linewidth ferromagnetic resonance establish low-loss dynamic functionalities. A general pathway achieve these requirements is still lacking. Here, we demonstrate that rare-earth trace element doping...
<title>Abstract</title> Background Swine influenza A viruses (swIAV) are highly contagious zoonotic pathogens that cause an acute respiratory infection in pigs, presenting substantial economic and health risks. This drives the pig industry stakeholders animal to monitor swIAV livestock. Prior 2009 flu pandemic, H1<sub>av</sub>N1 (HA-1C.2.1) H1<sub>hu</sub>N2 (HA-1B.1.2.3) circulated herds France. The H1N1<sub>pdm</sub> (HA-1A.2.3.3) lineage became enzootic after its introduction. In 2020, a...
Edelfosine is an inhibitor of SK3 channel – mediated cell migration. However, this compound bears adverse in vivo side effects. Using dependent cell-migration assay, patch-clamp, 125I-apamin binding, and experiments we tested the ability 15 lipid derivatives with chemical structures inspired from edelfosine to inhibit channels. a structure-activity relationship approach identified analog named Ohmline (1-O-hexadecyl- 2-O-methyl-sn-glycero-3-lactose) potent inhibitory effects on channel. Its...
Swine skin is one of the best structural models for human skin, widely used to probe drug transcutaneous passage and test new vaccination devices. However, little known about its composition in immune cells, among them dendritic cells (DC), that are essential initiation response. After a first seminal work describing four different DC subpopulations pig we hereafter deepen characterization these showing similarities between swine subsets their counterparts. Using comparative transcriptomic...
Viral respiratory diseases remain of major importance in swine breeding units. Swine influenza virus (SIV) is one the main known contributors to infectious diseases. The innate immune response viruses has been assessed many previous studies. However most these studies were carried out a single-cell population or directly live animal, all its complexity. In current study we report use trachea epithelial cell line (newborn pig cells – NPTr) comparison with alveolar macrophages and lung slices...
Abstract In 2018, a veterinarian became sick shortly after swabbing sows exhibiting respiratory syndrome on farm in France. Epidemiologic data and genetic analyses revealed consecutive human-to-swine swine-to-human influenza A(H1N1)pdm09 virus transmission, which occurred despite some biosecurity measures. Providing pig industry workers the annual vaccine might reduce transmission risk.
A diversifying pool of mammalian-adapted influenza viruses (IAV) with largely unknown zoonotic potential is maintained in domestic swine populations worldwide. The most recent human pandemic 2009 was caused by a virus genes originating from IAV isolated swine. Swine (SIV) are widespread European pig and evolve dynamically. Knowledge regarding occurrence, spread evolution potentially SIV Europe poorly understood.Efficient surveillance programmes depend on sensitive specific diagnostic methods...