A5034708896- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Animal Virus Infections Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Animal Disease Management and Epidemiology
- Virus-based gene therapy research
- Chemokine receptors and signaling
- Glycosylation and Glycoproteins Research
- Viral gastroenteritis research and epidemiology
- Immune cells in cancer
- vaccines and immunoinformatics approaches
- RNA Interference and Gene Delivery
- Galectins and Cancer Biology
- Xenotransplantation and immune response
- Neuroinflammation and Neurodegeneration Mechanisms
- Antimicrobial Peptides and Activities
- Aquaculture disease management and microbiota
- CAR-T cell therapy research
- Media and Digital Communication
- Cinema History and Criticism
- Viral Infections and Immunology Research
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
2014-2025
Consejo Superior de Investigaciones Científicas
1988-2023
Instituto de Biotecnología de León
2009-2017
Universidade da Coruña
2002
Centro Regional de Selección y Reproducción Animal
1996-2000
Centro de Investigación en Sanidad Animal
1996-2000
National Institute of Allergy and Infectious Diseases
1988-1992
National Institutes of Health
1988-1992
Hospital Universitario Fundación Jiménez Díaz
1982-1992
May Institute
1989
Abstract The mAb 2A10 recognizes a 120-kDa protein with sequence homology to the human CD163 and whose expression is restricted cells of porcine monocyte/macrophage lineage. While most tissue macrophages express high levels Ag, bone marrow subset blood monocytes are negative for this marker. percentage 2A10+ ranges between 5–50% depending on donor. phenotypic analysis indicates that these more similar mature than 2A10− monocytes. higher swine histocompatibility leukocyte Ag II, CD16,...
We describe the structural organization of human SCL gene, a helix-loop-helix family member which we believe plays fundamental role in hematopoietic differentiation. The locus is composed eight exons distributed over 16 kb. shows pattern expression quite restricted to early tissues, although malignant states gene may be somewhat extended into later developmental stages. A detailed analysis transcript(s) arising from revealed that (i) 5' noncoding portion transcript, resides within CpG...
ABSTRACT We have analyzed the production of tumor necrosis factor alpha (TNF-α) induced by in vitro infection with African swine fever (ASF) virus (ASFV) and systemic local release this inflammatory cytokine upon vivo infection. An early increase TNF-α mRNA expression was detected ASFV-infected alveolar macrophages, high levels protein were ELISA culture supernatants from these cells. When animals experimentally infected a virulent isolate (E-75), enhanced mainly affected organs correlated...
Summary Swine monocytes constitute a heterogeneous population of cells which can be divided into four subsets based on the expression SWC3, CD14, CD163 and swine leucocyte antigen (SLA) DR markers. These appear to represent different maturation stages in pathway along these up‐regulate SLA antigens reduce that CD14. Differences adhesion costimulatory molecules are also patent, with progressive increase CD11a, wCD11R1, CD29, CD49d, CD61, CD1a CD80/86, concomitant decrease wCD11R2. Besides,...
Swine skin is one of the best structural models for human skin, widely used to probe drug transcutaneous passage and test new vaccination devices. However, little known about its composition in immune cells, among them dendritic cells (DC), that are essential initiation response. After a first seminal work describing four different DC subpopulations pig we hereafter deepen characterization these showing similarities between swine subsets their counterparts. Using comparative transcriptomic...
SWC3 was defined at the First International Swine CD Workshop as a specific myelomonocytic antigen of 230 kDa with mAbs 74‐22‐15, 6F3 and DH59B. In this report, we describe two new (BL1H7 BA1C11) that react selectively granulocytes, monocytes macrophages. These monoclonal antibodies (mAbs) recognize molecule in range 90–115 immunoprecipitation and/or Western blotting analyses. Two‐colour FACS analyses showed distribution BL1H7 BA1C11 antigens identical to SWC3. Moreover, assay, mAb 74‐22‐15...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPrimary structure of papain-solubilized human histocompatibility antigen HLA-B27Angel Ezquerra, Rafael Bragado, Miguel A. Vega, Jack L. Strominger, James Woody, and Jose Lopez de CastroCite this: Biochemistry 1985, 24, 7, 1733–1741Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/bi00328a025https://doi.org/10.1021/bi00328a025research-articleACS...
By using cytolytic T lymphocytes (CTL), the HLA-A2 serologic specificity may be divided into at least four subtypes designated as A2.1 to A2.4. The HLA-A2.4 antigen expressed by donor CLA is not recognized allogeneic CTL specific for either A2.1, A2.2, or A2.3, but indistinguishable from HLA-A2.1 H-Y-specific, HLA-A2-restricted and isoelectric focusing. structure of this was compared with known main subtype on JY cells establish molecular basis immunologic differences between two antigens....
Monocyte subsets have been shown to differ in the pattern of chemokine receptor expression and their migratory properties, both human mouse. Previously we characterized swine several monocyte subpopulations, based on CD163, Tük4 SLA-II, which share features with populations described Here, analysed different receptors CD163-Tük4+SLA-II- CD163+Tük4-SLA-II+ porcine monocytes. monocytes expressed higher CX3CR1 but lower CCR2 CXCR4 mRNA levels than Moreover, CCL2 binding Tük4+SLA-II- not...