A5027220960- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Respiratory viral infections research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Animal Nutrition and Physiology
- Virus-based gene therapy research
- Vector-Borne Animal Diseases
- Viral Infections and Vectors
- Veterinary medicine and infectious diseases
- vaccines and immunoinformatics approaches
- Herpesvirus Infections and Treatments
- Mosquito-borne diseases and control
- Viral Infections and Immunology Research
- Ruminant Nutrition and Digestive Physiology
- Agriculture and Farm Safety
- Virology and Viral Diseases
- Probiotics and Fermented Foods
- Salmonella and Campylobacter epidemiology
- Reproductive tract infections research
- Mycotoxins in Agriculture and Food
- Plant and fungal interactions
- Leptospirosis research and findings
- MicroRNA in disease regulation
- Protein Hydrolysis and Bioactive Peptides
University of Georgia
2015-2024
Auburn University
2020-2024
Center for Surveillance, Epidemiology, and Laboratory Services
2022-2024
Emory University
2014-2023
Office of Infectious Diseases
2020
Shandong Provincial Hospital
2017
Shandong University
2017
Ghent University
2009-2017
Aristotle University of Thessaloniki
2002-2017
University of Thessaly
2014-2015
Swine influenza causes concern for global veterinary and public health officials. In continuing two previous networks that initiated the surveillance of swine viruses (SIVs) circulating in European pigs between 2001 2008, a third Surveillance Network Influenza Pigs (ESNIP3, 2010–2013) aimed to expand widely knowledge epidemiology SIVs. ESNIP3 stimulated programs harmonized SIV countries supported coordination appropriate diagnostic tools subtyping methods. Thus, an extensive virological...
The 2009 H1N1 lineage represented the first detection of a novel, highly transmissible influenza A virus genotype: six gene segments originated from North American triple-reassortant swine lineage, and two segments, NA M, derived Eurasian avian-like lineage. As neither parental transmits efficiently between humans, adaptations mechanisms underlying pandemic spread swine-origin strain are not clear. To help identify determinants transmission, we used reverse genetics to introduce an early...
The aim of the study was to assess efficacy BioPlus 2B, a probiotic containing Bacillus licheniformis and B. subtilis spores, on health status productivity pigs, during weaning, growing finishing stages growth. On commercial farrow-to-finish farm, five experimental groups were formed, each 54 weaned piglets. pigs first group (double controls) received normal feed with no second (untreated 2B only weaning stage. third, fourth fifth same as but, at part stages, supplemented three different...
Influenza D virus (IDV), a new member of the Orthomyxoviridae family, was first reported in 2011 swine Oklahoma, and consequently found cattle across North America Eurasia. To investigate circulation IDV among pigs Italy, period between June 2015 May 2016, biomolecular virological tests were performed on 845 clinical samples collected from 448 pig farms affected by respiratory distress located Po Valley. Serological conducted 3698 sera, including archive sera 2009, as well same region. Viral...
We established primary porcine nasal, tracheal, and bronchial epithelial cells that recapitulate the physical functional properties of respiratory tract have ability to fully differentiate. Trans-well cultures demonstrated increased transepithelial electrical resistance over time presence tight junctions as by immunohistochemistry. The developed cilia, secreted mucus, expressed sialic acids on surface glycoproteins, latter which are required for influenza A virus infection. Swine viruses...
This study presents the results of virological surveillance for swine influenza viruses (SIVs) in Belgium, UK, Italy, France and Spain from 2006 to 2008. Our major aims were clarify occurrence three SIV subtypes - H1N1, H3N2 H1N2 at regional levels, identify novel reassortant antigenically compare SIVs with human H1N1 viruses. Lung tissue and/or nasal swabs outbreaks acute respiratory disease pigs investigated by virus isolation. The hemagglutinin (HA) neuraminidase (NA) determined using...
We tested serum samples from pigs infected or vaccinated with European swine influenza viruses (SIVs) in hemagglutination-inhibition assays against pandemic (H1N1) 2009 virus and related North American SIVs. found more serologic cross-reaction than expected. Data suggest Europe may have partial immunity to virus.
ABSTRACT Position 41 of the influenza A virus matrix protein encodes a highly conserved alanine in human and avian lineages. Nonetheless, strains Eurasian avian-like swine (Easw) lineage contain change at this position: position A/swine/Spain/53207/04 (H1N1) (SPN04) proline. To assess impact naturally occurring polymorphism on viral fitness, we utilized reverse genetics to produce recombinant viruses encoding wild-type M1 41P (rSPN04-P) consensus 41A (rSPN04-A) residues. Relative rSPN04-A,...
ABSTRACT Since the 1990s, endemic North American swine influenza A viruses (swFLUAVs) contained an internal gene segment constellation, triple reassortment (TRIG) cassette. In 2009, H1N1 pandemic (pdmH1N1) virus spilled back into but did not become endemic. However, pdmH1N1 contributed matrix (pdmM) to swFLUAVs circulating in pig population, which replaced classical (swM) found TRIG cassette, suggesting pdmM has a fitness benefit. Others have shown that containing greater transmission...
Vaccination with live-attenuated polio vaccine has been the primary reason for drastic reduction of poliomyelitis worldwide. However, reversion this attenuated poliovirus occasionally results in emergence vaccine-derived polioviruses that may cause poliomyelitis. Thus, development anti-poliovirus agents remains a priority control and eradication disease. MicroRNAs (miRNAs) have shown to regulate viral infection through targeting genome or reducing host factors required virus replication....
The purpose of the study was to investigate whether, on farms with both post-weaning multisystemic wasting syndrome (PMWS) and porcine reproductive respiratory (PRRS), PRRS vaccination sows their fattening pigs protects against these syndromes. In a farrow-to-finish pig farm history PMWS, 200 gilts were allocated one two groups equal size. first group (C-sow group) used as untreated controls, while animals second (V-sow vaccinated live Porcilis vaccine. At next weaning, all piglets half C...
Influenza A viruses (IAVs) pose a global health threat, contributing to hundreds of thousands deaths and millions hospitalizations annually. The two major surface glycoproteins IAVs, hemagglutinin (HA) neuraminidase (NA), are important antigens in eliciting neutralizing antibodies protection against disease. However, NA is generally ignored the formulation development influenza vaccines. In this study, we evaluate immunogenicity efficacy challenge novel virus-like particles (VLPs) vaccine...