A5049055584- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Vector-Borne Animal Diseases
- Influenza Virus Research Studies
- Hepatitis Viruses Studies and Epidemiology
- Microbial infections and disease research
- Virus-based gene therapy research
- Viral Infections and Vectors
- Viral Infections and Immunology Research
- Veterinary medicine and infectious diseases
- Animal Behavior and Welfare Studies
- Zoonotic diseases and public health
- SARS-CoV-2 and COVID-19 Research
- Salmonella and Campylobacter epidemiology
- Respiratory viral infections research
- T-cell and Retrovirus Studies
- Antibiotic Resistance in Bacteria
- Virology and Viral Diseases
- Mosquito-borne diseases and control
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- SARS-CoV-2 detection and testing
- Agriculture and Farm Safety
- Viral Infectious Diseases and Gene Expression in Insects
Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
2015-2024
Centre Hospitalier de Niort
2019-2024
Département Santé Animale
2023
CEA Paris-Saclay
2015-2022
Université Bretagne Loire
2016-2020
Université Européenne de Bretagne
2013-2015
University of Antwerp
2011-2013
Centre Hospitalier de Fougères
2010-2011
Understanding the mechanisms involved in long-term persistence of humoral immunity after natural infection or vaccination is challenging and crucial for further research immunology, vaccine development as well health policy. Long-lived plasma cells, which have recently been shown to reside survival niches bone marrow, are instrumental process induction persistence. We developed a mathematical model, assuming two antibody-secreting cell subpopulations (short- long-lived cells), analyze...
Concomitant infections by different influenza A virus subtypes within pig farms increase the risk of new reassortant emergence. The aims this study were to characterize epidemiology recurrent swine and identify their main determinants. follow-up was carried out in 3 selected known be affected repeated infections. Three batches pigs followed each farm from birth slaughter through a representative sample 40 piglets per batch. Piglets monitored individually on monthly basis for serology...
Hepatitis E virus (HEV) can cause enterically-transmitted hepatitis in humans. The zoonotic nature of infections has been established industrialized areas and domestic pigs are considered as the main reservoir. dynamics transmission pig herds therefore needs to be understood reduce prevalence viremic at slaughter prevent contaminated products from entering food chain. An experimental trial was carried out study characteristics HEV between orally inoculated naïve animals. A mathematical model...
In Europe, modified live vaccines (MLV) are commonly used to control porcine reproductive and respiratory syndrome virus (PRRSV) infection. However, they have been associated with safety issues such as reversion virulence induced by mutation and/or recombination. On a French pig farm, we identified field recombinant strain derived from two PRRSV-1 MLV (MLV1). As result, aimed evaluate its clinical, virological, transmission parameters in comparison both parental strains. Three groups six...
Abstract Background Porcine reproductive and respiratory syndrome (PRRS) is a viral disease with worldwide distribution an enormous economic impact. To control PRRS virus (PRRSV) infection, modified live vaccines (MLVs) are widely used in the field, mainly administered via intramuscular (IM) route. Currently, some MLVs authorized for intradermal (ID) administration, which has many practical welfare advantages. The objectives of study were to compare immune responses (systemic blood mucosal...
A transmission experiment involving 5-week-old specific-pathogen-free (SPF) piglets, with (MDA+) or without maternally-derived antibodies (MDA−), was carried out to evaluate the impact of passive immunity on a swine influenza virus (swIAV). In each group (MDA+/MDA−), 2 seeders were placed 4 piglets in direct contact and 5 indirect (3 replicates per group). Serological kinetics (ELISA) individual viral shedding (RT-PCR) monitored for 28 days after infection. MDA waning estimated using...
Abstract African swine fever (ASF) has affected Romania since July 2017, with considerable economic and social consequences, despite the implementation of control measures mainly based on stamping out infected pig populations. On basis 2973 cumulative recorded cases up to September 2019 among wild boars domestic pigs, analysis epidemiological characteristics could help identify factors favoring persistence spread ASF. A statistical framework, a random forest methodology, was therefore...
In developed countries, most of hepatitis E human cases are zoonotic origin. Swine is a major virus (HEV) reservoir and foodborne transmissions after pork product consumption have been described. The risk for HEV-containing pig livers at slaughter time related to the age infection shedding duration. Porcine Reproductive Respiratory Syndrome Virus (PRRSV) that impairs immune response; it highly prevalent in production areas suspected influence HEV dynamics. impact PRRSV on features infections...
African swine fever (ASF) has one of the highest case-fatality rates among pig diseases. Europe was considered ASF-free for about two decades until 2007, when virus introduced into Georgia. Since then, it been identified throughout Eastern Europe, and reached Belgium in late 2018, increasing risk ASF being neighboring countries—namely Germany, Luxembourg, Netherlands France. French authorities have therefore reinforced surveillance measures to improve probability detecting rapidly if emerges...
Controlling enzootic diseases, which generate a large cumulative burden and are often unregulated, is needed for sustainable farming, competitive agri-food chains, veterinary public health. We discuss the benefits challenges of mechanistic epidemiological modelling livestock enzootics, with particular emphasis on need interdisciplinary approaches. focus issues arising when pathogen spread at various scales (from farm to region) better assess disease control propose targeted options. in...
Pathogen spread between farms results from interaction the epidemiological characteristics of infectious agents, such as transmission route, and contact structure holdings. The objective our study was to design network models pig movements matching with features pathogens. Our first model represents diseases only through introduction animals holdings (Animal Introduction Model AIM), whereas second one also accounts for pathogen intermediate transit trucks even without any animal unloading...
The spread of highly pathogenic avian influenza (HPAI) viruses worldwide has serious consequences for animal health and a major economic impact on the poultry production sector. Since 2014, Europe been severely hit by several HPAI epidemics, with France being most affected country. Most recently, was again two devastating epidemics in 2020-21 2021-22. We conducted descriptive analysis 2021-22 as first step towards identifying sector's remaining vulnerabilities regarding France. examined...
Passive immunity (PI), acquired through colostrum intake, is essential for piglet protection against pathogens. Maternally-derived antibodies (MDAs) can decrease the transmission of pathogens between individuals by reducing shedding from infected animals and/or susceptibility naïve animals. Only a limited number studies, however, have been carried out to quantify level conferred PI in terms transmission. In present study, an original modeling framework was designed estimate parameters...
From the severe porcine epidemic diarrhoea (PED) epidemics that struck in 2013 United States of America and other countries North South America, two types virus (PEDV) were isolated, namely InDel non-InDel strains. They are differentiated by insertions/deletions S1 nucleotide sequence S gene, differences virulence observed from clinical cases. In 2014, a PED outbreak occurred pig farm France, which an strain was isolated. This study aimed at comparing, under experimental conditions,...
Swine Influenza A Viruses (swIAVs) have been shown to persist in farrow-to-finish pig herds with repeated outbreaks successive batches, increasing the risk for respiratory disorders affected animals and being a threat public health. Although general routes of swIAV transmission (i.e. direct contact exposure aerosols) were clearly identified, process between batches is still not fully understood. Maternally derived antibodies (MDAs) stressed as possible factor favoring within-herd...