A5032596006- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Non-Invasive Vital Sign Monitoring
- Blood Pressure and Hypertension Studies
- Anesthesia and Sedative Agents
- Heart Rate Variability and Autonomic Control
- Sepsis Diagnosis and Treatment
- Anesthesia and Pain Management
- Cardiac Ischemia and Reperfusion
- Muscle activation and electromyography studies
- Anesthesia and Neurotoxicity Research
- Advanced Sensor and Energy Harvesting Materials
- Cardiovascular Health and Disease Prevention
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Renal function and acid-base balance
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Ultrasound in Clinical Applications
- Nitric Oxide and Endothelin Effects
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Cardiac electrophysiology and arrhythmias
- Hormonal Regulation and Hypertension
- Venous Thromboembolism Diagnosis and Management
- Intensive Care Unit Cognitive Disorders
Centre Hospitalier Universitaire de Lille
2016-2025
Université de Lille
2010-2025
Unité de Technologies Chimiques et Biologiques pour la Santé
2025
Evaluation des technologies de santé et des pratiques médicales
2020-2024
Technologies pour la Santé
2022
Hôpital Roger Salengro
2000-2020
Lille’s Cardiology Hospital
1996-2018
Hôpital Beaujon
2018
Centre Oscar Lambret
2011-2016
Imation (United States)
1998-2015
Perioperative hypotension is associated with an increase in postoperative morbidity and mortality, but the appropriate management strategy remains uncertain.To evaluate whether individualized blood pressure tailored to individual patient physiology could reduce organ dysfunction.The Intraoperative Norepinephrine Control Arterial Pressure (INPRESS) study was a multicenter, randomized, parallel-group clinical trial conducted 9 French university nonuniversity hospitals. Adult patients (n = 298)...
Background Monitoring left ventricular preload is critical to achieve adequate fluid resuscitation in patients with hypotension and sepsis. This prospective study tested the correlation of pulmonary artery occlusion pressure, end-diastolic area index measured by transesophageal echocardiography, arterial systolic pressure variation (the difference between maximal minimal blood values during one mechanical breath), its delta down (dDown) component (= apneic - minimum pressure) response...
Respiratory arterial pulse pressure variations (PPV) are the best predictors of fluid responsiveness in mechanically ventilated patients during general anesthesia. However, previous studies were performed a small number and determined single cutoff point to make clinical discrimination. The authors sought test predictive value PPV large, multicenter study express it using gray zone approach.The studied 413 anesthesia mechanical ventilation four centers. PPV, central venous pressure, cardiac...
Continuous Analgesia / Nociception balance evaluation during general anesthesia could be of precious help for the optimization analgesic drugs delivery, limiting risk toxicity due to use opioid drugs, post operative hyper algesia, and, probably, reducing time recovery after surgical procedure. Heart Rate Variability analysis has been shown in several studies measure Autonomic Nervous System tone, which is strongly influenced by anesthetic drugs. Recording RR series enabled us observe that...
Cardiac output (CO) is rarely monitored during surgery, and arterial pressure remains the only hemodynamic parameter for assessing effects of volume expansion (VE). However, whether VE-induced changes in accurately reflect CO has not been demonstrated. The authors studied ability pulse variation to detect induced by VE perioperative period.The 402 patients four centers. Hemodynamic variables were recorded before after VE. Response was defined as more than 15% increase CO. assessed using a...
The world is currently facing an unprecedented healthcare crisis caused by the COVID-19 pandemic. objective of these guidelines to produce a framework facilitate partial and gradual resumption intervention activity in context group has endeavoured minimum number recommendations highlight strengths be retained 7 predefined areas: (1) protection staff patients; (2) benefit/risk patient information; (3) preoperative assessment decision on intervention; (4) modalities preanaesthesia...
General anesthesia and procedural sedation are common practice for mechanical thrombectomy in acute ischemic stroke. However, risks benefits of each strategy unclear.
The peri-operative management of patients undergoing surgery for phaeochromocytoma or paraganglioma with calcium channel blockers (CCB) and their impact on postoperative morbidity mortality were studied. medical records 105 between 1991 2002 analysed retrospectively. In all patients, the blocker nicardipine was used haemodynamic changes. Sixty-five (61.9%) showed transient intra-operative hypertension. Systolic blood pressure (SBP) > 220 mmHg SBP 180 10 consecutive minutes observed in 14...
The optimization of analgesic drugs delivery during general anesthesia (GA) requires to evaluate the pain/analgesia balance. Heart Rate Variability (HRV) analysis has long been shown measure autonomic nervous system tone, which is strongly influenced by anesthetic drugs. Power spectrum measurements are widely used assess HRV low (LF) and high frequency (HF) ranges, related sympathetic parasympathetic systems. We have developed an original graphic measurement technique (EnvTOT) ventilatory...
The Analgesia Nociception Index (ANI) monitor measures the relative parasympathetic tone as a surrogate for antinociception/nociception balance during general anesthesia. aims of this observational study were to test whether ANI could early detect hemodynamic reactivity (HemodR) propofol anesthesia, measure pain in conscious patients after surgery, and determine predictive thresholds.After institutional approval informed consent, adult scheduled total knee replacement included. Propofol was...
Dynamic predictors of fluid responsiveness have made automated management resuscitation more practical. We present initial simulation data for a novel closed-loop fluid-management algorithm (LIR, Learning Intravenous Resuscitator). The performance the was tested in three phases by using patient simulator including pulse-pressure variation output. In first phase, LIR different hemorrhage scenarios and compared with no management. second we 20 practicing anesthesiologists simulated scenario....
Abstract Introduction The purpose of this study was to evaluate the clinical relevance high values central venous-to-arterial carbon dioxide difference (PCO 2 gap) in high-risk surgical patients admitted a postoperative ICU. We hypothesized that PCO gap could serve as useful tool identify still requiring hemodynamic optimization at ICU admission. Methods One hundred and fifteen were included prospective single-center observational during 1-year period. High-risk inclusion criteria adapted...
The subcellular mechanisms underlying intrinsic myocardial depression during sepsis remain poorly defined, in particular the relative roles of altered intracellular Ca2+ transients versus changes myofilament properties. We studied contractile function cardiac myocytes isolated 12 h after induction endotoxemia (5 mg/kg intravenous E. coli lipopolysaccharide [LPS]) conscious rats. Cardiomyocytes from LPS-injected rats had depressed twitch shortening compared with control cells (4.10.2%...
Background Postoperative pulmonary complications is a major issue that affects outcomes of surgical patients. The hypothesis was the intraoperative ventilation parameters are associated with occurrence postoperative complications. Methods A single-center retrospective cohort study conducted at Lille University Hospital, France. included 33,701 adults undergoing noncardiac, nonthoracic elective surgery requiring general anesthesia tracheal intubation between January 2010 and December 2019....
BACKGROUND: Mechanical thrombectomy is the treatment of choice for ischemic strokes anterior circulation with proximal occlusion. can be performed under sedation, which lead to episodes periprocedural agitation. The aim this study describe prevalence agitation and determine consequences during after mechanical thrombectomy. METHODS: This an ancillary AMETIS (Anesthesia Management in Endovascular Therapy Ischemic Stroke). We evaluated patients from sedation group randomized trial; some...