Double antibody radioimmunoassays have been developed to measure gonadotropinreleasing hormone (Gn-RH). Thyrotropin-releasing hormone, melanocyte-stimulating inhibiting factor, various Gn-RH analogs and the components of serum per se did not appear influence assay. Serum containing endogenous or plus exogenous Gn-RH, crude hypothalamic extracts, analogues all produced inhibition curves which were parallel those obtained with synthetic standard. Exogenous could be quantitatively recovered...

Crude extracts of commercially availa-ble ovine, bovine and porcine pineal glands were found to contain high levels gonadotropin-releasing activity. The hor-mone (Gn-RH) radioimmunoassay values (porcine, 185 ng/gland; bovine, 500 490 ng/gland) consistent with obtained by in vitro Gn-RH bioassay. con-tained 4–10 times as much activity that reported hypothalami the corresponding species. To verify this ratio, fresh from 4 ewes similarly extracted. pineal:hypothalamus ratio was be more than...

Abstract Background Physical activity and exercise are promoted worldwide as effective interventions for healthy ageing. Various initiatives have been developed evaluated their efficacy effectiveness among older populations. However, a deeper understanding of participants’ experiences with these is crucial to foster long-term persons. Methods A constructivist grounded theory study was conducted explore the persons participating in supervised group supramaximal high-intensity training (HIT)...

INTRODUCTION: Learning-related morphological changes in brain connectivity remain poorly understood. Network analysis techniques provide robust interpretation of high-dimensional neural data during skill acquisition. This insight may reveal novel anatomical and personalized targets for restoring performance individuals with intellectual disabilities, who today possess sparse therapeutic offerings. METHODS: Task-paired electrode were collected from 23 subjects undergoing sEEG epilepsy...

INTRODUCTION: Human cognition involves the complex coordination of interconnected networks, where pre-task spontaneous network states can prime brain performance. Thalamocortical communication is known to be a crucial element attentional processes. METHODS: We employed temporal expectancy task in 24 humans and 6 wild-type mice, consisting an initial cue followed by go separated variable time interval, response cue. subjects were implanted with iEEG, mice injected fluorescent Ca2+ indicator...

INTRODUCTION: Learning and intellectual disabilities (LID) significantly impact cognitive functions such as attention memory. A crucial aspect of processing, control, involves the neural adaptation to internal external states, engaging global networks drive goal-directed behavior. The role intra-thalamic interactions in modulating control remains unexplored humans. METHODS: Stereotactic electroencephalography (sEEGs) data was recorded from patients undergoing monitoring for refractory...

Abstract Background This study examined the effects of regulated and controlled supramaximal high-intensity interval training (HIT) adapted for older adults, compared to moderate-intensity (MIT), on cardiorespiratory fitness; cognitive, cardiovascular, muscular function; quality life. Methods Sixty-eight nonexercising adults (66–79 years, 44% males) were randomized 3 months twice-weekly HIT (20-minute session including 10 × 6-second intervals) or MIT (40-minute 8-minute stationary bicycles...

This analysis of secondary outcomes investigated the applicability supramaximal High-intensity interval training (HIT) with individually prescribed external intensity performed on stationary bicycles. Sixty-eight participants a median (min;max) age 69 (66;79), at time not engaged in regular exercise were randomized to 25 twice-weekly sessions HIT (20-minute session 10 × 6-second intervals) or moderate (MIT, 40-minute 3 8-minute intervals). The primary aim was regarding; adherence intensity,...

ORIGINAL RESEARCH article Front. Hum. Neurosci., 07 September 2012Sec. Motor Neuroscience Volume 6 - 2012 | https://doi.org/10.3389/fnhum.2012.00255

Aim. Establishing the effects of low intensity cycling (LC), moderate (MC), and standing at a simulated office workstation on pain modulation, work performance, metabolic expenditure. Methods. 36 healthy adults (21 females), mean age 26.8 (SD 7.6) years, partook in this randomized<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn fontstyle="italic">3</mml:mn><mml:mo>×</mml:mo><mml:mn fontstyle="italic">3</mml:mn></mml:math>crossover trial with 75 minutes LC 20% maximum...

High-intensity training (HIT) with extremely short intervals (designated here as supramaximal HIT) is a time-efficient method for health and performance. However, protocol regulation control of intensity missing, impeding implementation in various groups, such older individuals.

Beyond being a pulmonary disease, chronic obstructive disease (COPD) presents with extrapulmonary manifestations including reduced cognitive, cardiovascular, and muscle function. While exercise training is the cornerstone in non-pharmacological treatment of COPD, there need for new methods due to suboptimal adaptations when following traditional guidelines, often applying moderate-intensity continuous (MICT). In people short-duration high-intensity interval (HIIT) holds potential induce more...

Abstract Objective This study investigated the effectiveness of supramaximal high-intensity interval training (supramaximal HIT) on muscle capacities and physical function compared to moderate-intensity (MIT) for older adults. Methods Sixty-eight adults (66–79 years, 56% women), not engaged in regular exercise, were randomised 3 months twice-weekly HIT (20 minutes including 10 × 6-second intervals) or MIT (40 8-minute intervals). Both groups performed stationary bicycles a group setting....

<b>Background:</b> Family history is one of the most consistent risk factors for dementia. Therefore, analysis families with a distinct inheritance pattern disease can be powerful approach identification previously unknown genes. <b>Objective:</b> To map susceptibility regions Alzheimer’s disease. <b>Methods:</b> A complete genome scan 369 microsatellite markers was carried out in 12 extended collected Sweden. Age at onset ranged from 53 to 78 years, but 10 there least member age ⩽65 years....

The decapeptide amide, pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, corresponding to the amino acid sequence of porcine gonadotropin-releasing hormone (Gn-RH), was synthesized by solid-phase method. protected product purified chromatography on two silica-gel columns and crystallization from hot methanol. Following hydrogen fluoride deblocking anion-exchange, peptide gel-filtration through Sephadex G-25 followed G-15. This analyzed optical rotation, elemental analysis, thin-layer...

Elastic resistance as a tool for evaluation of muscular strength has rarely been addressed even though it is commonly used in exercise and rehabilitation regimens involving the shoulder muscles. The aim was therefore to investigate relationship potential difference between development force during maximal isokinetic (maximum peak force, maximum mean force) elastic (one-repetition (1 RM)) concentric flexion healthy older adults. A total 30 voluntary adults over age 50 (15 women, 15 men) were...

Congenital heart block (CHB) is a potentially lethal condition characterized by third-degree atrioventricular (AVB). Despite anti-Ro52 antibodies being detected in nearly 90% of mothers affected children, CHB occurs only 1-2% anti-Ro/Sjögren's-syndrome-related antigen A (SSA) autoantibody-positive pregnancies. Maternal have been suggested to bind molecules crucial fetal cardiac function; however, it remains unknown whether single antibody profile associates with or several specificities and...

Our objective was to assess the loading during a resistance-training task at given training intensity in subjects with stroke and healthy subjects. Subjects (n = 11) two control groups 11 each) underwent strength measurements for elbow flexors. Torque muscular activity obtained related values measurements. Even if relative throughout concentric phase of task, expressed as percent isokinetic torque, found be similar among groups, we indications insufficient group. Relative eccentric...

Abstract Objective The aims of this study among municipal employees in rural areas northern Sweden were to assess the prevalence self-rated exhaustion disorder (s-ED), describe plausible between-group differences self-reported health-related factors with or without s-ED, and identify associated s-ED. Methods In a cross-sectional study, data collected from 1093 (76.1% women) two using an instrument measuring s-ED health variables drawn Modern Worklife Questionnaire (MWQ), Perceived Stress...

High-intensity exercise is essential for optimal development of cardiorespiratory fitness and health. This is, however, challenging most people with chronic obstructive pulmonary disease (COPD) due to ventilatory limitations, leading at lower intensities accompanied by suboptimal stress on the cardiovascular muscular system. PURPOSE: To compare acute effects a novel concept short-duration supramaximal high-intensity interval training (HIIT) vs. moderate-intensity continuous (MICT) in COPD...

The aim of this study was to compare the effect isokinetic contraction mode and velocity on torque-angle relationship during maximum voluntary elbow flexion in patients with stroke, age-matc ...

Ventrolateral prefrontal cortex (VLPFC) is part of a network that exerts inhibitory control over the motor (MC). Recently, we demonstrated VLPFC was more activated during imagined maximum eccentric than concentric contractions in healthy participants. This accompanied with lower activation levels within regions contractions. The aim to test novel hypothesis an involvement contraction mode-specific modulation force. Functional magnetic resonance imaging used examine differences and phases...